A5002284527- Gastric Cancer Management and Outcomes
- Renal Diseases and Glomerulopathies
- Metastasis and carcinoma case studies
- Chronic Kidney Disease and Diabetes
- Gastrointestinal Tumor Research and Treatment
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Autoimmune Bullous Skin Diseases
- Neurological and metabolic disorders
- Genetic and Kidney Cyst Diseases
- Gastrointestinal disorders and treatments
- Renal and Vascular Pathologies
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Renin-Angiotensin System Studies
- Cancer Diagnosis and Treatment
- Health Promotion and Cardiovascular Prevention
- Receptor Mechanisms and Signaling
- Multiple and Secondary Primary Cancers
- Artificial Intelligence in Healthcare and Education
St. Marianna University School of Medicine
2016-2025
CosMED Pharmaceutical (Japan)
2019-2024
University of Yamanashi
2019-2024
University of Yamanashi Hospital
2019-2024
The University of Tokyo
2015-2023
University of Toronto
2022
University School
2022
Suzuki (Japan)
2021
Weatherford College
2001-2021
Barro Colorado Island
2021
Digital health technologies, including telemedicine, mobile (mHealth), and remote monitoring, are playing a greater role in medical practice. Safe accurate management of information leads to the advancement digital health, which turn results number beneficial effects. Furthermore, mHealth can help lower costs by facilitating delivery care connecting people their providers. Mobile apps empower patients providers proactively address conditions through near real-time monitoring treatment,...
Background The integrity of data in a clinical trial is essential, but the current management process too complex and highly labor-intensive. As result, trials are prone to consuming lot budget time, there risk for human-induced error falsification. Blockchain technology has potential address some these challenges. Objective aim study was validate system that enables security medical using blockchain technology. Methods We have developed blockchain-based tested through breast cancer. project...
ABSTRACT Background Large language models (LLMs) are increasingly evaluated in medical education and clinical decision support, but their performance highly specialized fields, such as nephrology, is not well established. We compared two advanced LLMs, GPT-4 the newly released o1 pro, on comprehensive nephrology board renewal examinations. Methods administered 209 Japanese Self-Assessment Questions for Nephrology Board Renewal from 2014–2023 to pro using ChatGPT pro. Each question, including...
The CC chemokines may play an important role in the pathogenesis of chronic inflammatory diseases including rheumatoid arthritis, and their effects are thought to be mediated through CCR1 receptors. Several nonpeptide receptor antagonists that showed high affinity for human receptors have been identified; however, effectiveness animal models has scarcely demonstrated, probably due species selectivity antagonists. To elucidate pathophysiological murine disease, we looked a potent antagonist...
Background: Blockchain is emerging as an innovative technology for secure data management in many areas, including medical practice. A distributed blockchain network tolerant against fault, and the registered are resistant to tampering revision. The has a high affinity with digital medicine like mobile health (mHealth) provides reliability without labor-intensive third-party contributions. On other hand, of not insured before registration network. Furthermore, there issues regard how...
A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from compound identified by random screening, an exploratory that exhibited diverse display of pharmacophores was designed. After evaluating antagonistic activity, highly designed based on 3D-pharmacophore similarity known actives. d-proline amide class in this and found possess activity.
Acute kidney injury (AKI) is common after cardiovascular surgery and usually diagnosed on the basis of serum creatinine (SCr) level urinary output. However, SCr low sensitivity in patients with poor renal function. Because liver-type fatty-acid-binding protein (L-FABP) reflects tubular injury, we evaluated whether perioperative changes L-FABP predict AKI context abdominal aortic repair. Study participants were 95 who underwent endovascular aneurysm repair (EVAR) 42 open We obtained urine...
Abstract Study Objectives This study assessed the effects and safety of smartphone-based cognitive behavioral therapy for insomnia (CBT-I) app compared with sham app. Methods In this multicenter, double-blind, parallel-group study, 175 patients were randomized to a CBT-I (Active, n = 87) or (Sham, 88) group. The primary endpoint was change in Athens Insomnia Score (AIS) from baseline after 8 weeks treatment. Results AIS (mean ± standard deviation) baseline, using modified-intent-to-treat...
To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang WT-Ang II) for 28 days. Control were injected with saline only (Tg-control WT-control). expressed proximal tubules Tg mice. After a high-dose injection II, gene expressions Tg-Ang increased significantly compared Tg-control Urinary excretion L-FABP greater than...
In the yeast Saccharomyces cerevisiae, glycosylphosphatidylinositol (GPI)-anchored proteins play important roles in cell wall biogenesis/assembly and formation of lipid microdomains. The moieties mature GPI-anchored typically contain either ceramide or diacylglycerol. Recent studies have identified that GPI phospholipase A2 Per1p O-acyltransferase Gup1p essential diacylglycerol-type remodelling proteins, while Cwh43p is involved to ceramide. It has been generally proposed...
ABSTRACT Background Large language models (LLMs) pretrained on vast amounts of data have significantly influenced recent advances in artificial intelligence. While GPT-4 has demonstrated high performance general medical examinations, its specialised areas such as nephrology is unclear. This study aimed to compare ChatGPT and Bard their potential clinical applications nephrology. Methods Ninety-nine questions from the Self-Assessment Questions for Nephrology Board Renewal 2018 2022 were...