A5029919604- Surgical Simulation and Training
- Enzyme Production and Characterization
- Peptidase Inhibition and Analysis
- Augmented Reality Applications
- Anatomy and Medical Technology
- Real-Time Systems Scheduling
- Virtual Reality Applications and Impacts
- Biochemical and Structural Characterization
- Intracranial Aneurysms: Treatment and Complications
- Embedded Systems Design Techniques
- Glioma Diagnosis and Treatment
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Teleoperation and Haptic Systems
- Chemical Synthesis and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Structure and Function
- Advanced Software Engineering Methodologies
- Microbial Metabolism and Applications
- Soft Robotics and Applications
- Spinal Fractures and Fixation Techniques
- Facial Nerve Paralysis Treatment and Research
- Advanced Neuroimaging Techniques and Applications
- 3D Shape Modeling and Analysis
The University of Tokyo
2016-2025
Muroran Institute of Technology
2024
Tokyo University of Pharmacy and Life Sciences
2023
Setsunan University
2012-2023
Takada Junior College
2023
National Defense Medical College
2023
Shionogi (Japan)
2010-2021
Tokyo University of Information Sciences
2015-2021
Osaka University
2008-2018
Futaba (Japan)
2010-2018
The systematic structure–activity relationship (SAR) of the muraymycins (MRYs) using an Ugi four-component reaction (U4CR) was investigated. impact lipophilic substituent on antibacterial activity significant, and analogues 8 9 having a side chain exhibited good against range Gram-positive bacterial pathogens, including MRSA VRE. Further investigation compounds revealed these to be selective inhibitors MraY transferase nontoxic HepG2 cells. SAR accessory urea–peptide moiety indicated that it...
Abstract The stigma of mental illness is a form negative judgmental knowledge and barrier to individual seeking treatment. Contact-based educational interventions with first-person perspective (1PP) combined immersive virtual reality (IVR) promising as an anti-stigma intervention. This study aims investigate the effectiveness 1PP IVR intervention compared video in enhancing depression reducing stigma, well examine corresponding brain activity change using functional magnetic resonance...
The gradual synchronization of the movement one's real hand with a virtual one can effectively induce sense embodiment (SoE) an avatar depression. Although neuroimaging studies have explored neural correlates some SoE subcomponents visuomotor synchronization, individual differences in and how humans acquire body representations through remain to be investigated. Here, we used right patient depression immersive reality (IVR) participants measured whole brain activity using functional magnetic...
The molecular structure of the pepstatin-insensitive carboxyl peptidase from Scytalidium lignicolum , formerly known as scytalidopepsin B, was solved by multiple isomorphous replacement phasing methods and refined to an R factor 0.230 ( free = 0.246) at 2.1-Å resolution. In addition unbound peptidase, a product complex cleaved angiotensin II bound in active site enzyme also determined. We propose name scytalidocarboxyl B (SCP-B) for this enzyme. On basis conserved, catalytic residues...
The 7 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) gene from Escherichia coli HB101 was cloned and expressed in E. DH1. hybrid plasmid pSD1, with a 2.8-kbp insert of chromosomal DNA at the BamHI site pBR322, subcloned into pUC19 to construct pSD3. entire nucleotide sequence an inserted PstI-BamHI fragment pSD3 determined by dideoxy chain-termination method. Within this sequence, mature enzyme protein-encoding found start GTG initiation codon comprise 765 bp, as judged comparison protein...
In this study, the authors used preoperative simulation employing 3D computer graphics (interactive graphics) to fuse all imaging data for brainstem cavernous malformations. The evaluated whether interactive or 2D correlated better with actual operative field, particularly in identifying a developmental venous anomaly (DVA).The study population consisted of 10 patients scheduled surgical treatment Data from (MRI, CT, and rotational angiography) were automatically fused using normalized...
γ-secretase inhibitors (GSI) are drugs developed to decrease amyloid-β peptide (Aβ) production by inhibiting intramembranous cleavage of β-amyloid protein precursor (βAPP). However, a large phase 3 trial semagacestat, potential non-transition state analog (non-TSA) GSI, in patients with Alzheimer's disease (AD) was terminated due unexpected aggravation cognitive deficits and side effects. Here, we show that some semagacestat effects clearly different from phenotype caused loss function...
Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold resembles that of subtilisin; however, they considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The defining features these a unique triad, Ser-Glu-Asp, as well presence an aspartic acid residue in oxyanion hole. High-resolution crystal structures have now been solved for sedolisin from Pseudomonas sp. 101, kumamolisin thermophilic bacterium, Bacillus novo MN-32....
The aim of this study was to investigate the regional differences in vivo vasodilator responses vasopressin, which is thought stimulate release nitric oxide from endothelium, canine cerebral arteries by angiography. Angiograms were performed through a catheter inserted directly into right vertebral artery and taken periodically after infusion vasopressin. diameters various segments major measured using computerized image analysis system. bolus administration vasopressin (10 pmol 1 nmol)...
To assess the value of an interactive visualization method for detecting offending vessels in neurovascular compression syndrome patients with facial spasm and trigeminal neuralgia. Computer graphics models are created by fusion fast imaging employing steady-state acquisition magnetic resonance angiography.High-resolution angiography were performed preoperatively 17 syndromes (facial spasm, n = 10; neuralgia, 7) using a 3.0-T scanner. computer software observed interactively detection...
Muraymycin analogues with a lipophilic substituent were synthesized using an Ugi four-component assemblage. This approach provides ready access to range of simply by altering the aldehyde component. The impact on antibacterial activity was very large, and 7b−e 8b−e exhibited good against Gram-positive bacterial pathogens including methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococcus faecium. study also showed that accessory urea-dipeptide motif contributes MraY...
Abstract The surgical education environment has been changing significantly due to restricted work hours, limited resources, and increasing public concern for safety quality, leading the evolution of simulation-based training in surgery. Of various simulators, low-fidelity simulators are widely used practice skills such as sutures because they portable, inexpensive, easy use without requiring complicated settings. However, since do not offer any teaching information, trainees self-practice...
Existing self-training materials are insufficient to learn open surgical procedures, and a new system that provides three-dimensional procedural information is needed. The effectiveness usability of providing by augmented reality (AR) were compared those an existing system, instructional video, in self-learning suturing surgery.This was prospective, evaluator-blinded, randomized, controlled study. Medical students who novices randomized into 2 groups: practice with the AR training (AR group)...
Abstract Background Robo1, Robo2 and Rig-1 (Robo3), members of the Robo protein family, are candidate receptors for chemorepellents Slit known to play a crucial role in commissural axon guidance spinal cord. However, their roles at other axial levels remain unknown. Here we examine expression proteins by cerebellofugal (CF) axons rostral hindbrain investigate CF pathfinding analysing knockout mice. Results We analysed originating from deep cerebellar neurons rodent embryos, focusing on...
Digital subtraction (DS) angiography is the gold standard for diagnosing spinal vascular malformations. Recently, multidetectorrow spiral CT and contrast-enhanced MR have been introduced as screening examinations before DS angiography. These methods, however, do not always determine accurate location of an arteriovenous shunt because resulting images lack information about cord or dura mater.Between April 2009 December 2010, 13 patients underwent imaging evaluations malformations at authors'...
Restoration of cranial nerve functions during acoustic neuroma (AN) surgery is crucial for good outcome. The effects minimizing the injury period and maximizing recuperation were investigated in 89 patients who consecutively underwent retrosigmoid unilateral AN surgery.Cochlear facial evaluated by use continuous auditory evoked dorsal cochlear nucleus action potential monitoring root exit zone-elicited compound muscle monitoring, respectively. Factors affecting preservation function at same...
Background As a consequence of indoor occupations and reduced exposure to sunlight, concerns have been raised that vitamin D deficiency is widespread in developed countries. Vitamin known be associated with increased risks morbidity mortality various diseases. Objective To investigate the serum status its relation life-style factors pregnant Japanese women. Methods Among cohort for 3,327 women who participated an adjunct study Japan Environment Children's Study during 2011–2013, which data...
Social relationships are a key determinant of social behaviour, and disruption behaviour is major symptom several psychiatric disorders. However, few studies have analysed among multiple individuals in group or how within influence the members with impaired socialisation. Here, we developed video-analysis-based system, Multiple-Animal Positioning System (MAPS), to automatically separately analyse housing. Using MAPS, show that isolation male mice during adolescence leads proximity adulthood....
Abstract We determined the associations of follow-up blood pressure (BP) after stroke as a time-dependent covariate with risk subsequent ischemic stroke, well those BP levels difference in impact long-term clopidogrel or aspirin monotherapy versus additional cilostazol medication on secondary prevention. In sub-analysis randomized controlled trial (CSPS.com), patients between 8 and 180 days onset were randomly assigned to receive alone, combination clopidogrel. The percent changes,...
Crystal structures of the serine-carboxyl proteinase from Pseudomonas sp. 101 (PSCP), complexed with a number inhibitors, have been solved and refined at high- to atomic-level resolution. All these inhibitors (tyrostatin, pseudo-tyrostatin, AcIPF, AcIAF, chymostatin, as well previously studied iodotyrostatin pseudo-iodotyrostatin) make covalent bonds active site Ser287 through their aldehyde moieties, while side chains occupy subsites S1−S4 enzyme. The mode binding is almost identical for P1...