A5006722983- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipoproteins and Cardiovascular Health
- Parkinson's Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood Pressure and Hypertension Studies
- Neurological disorders and treatments
- Intracranial Aneurysms: Treatment and Complications
- Genetic Neurodegenerative Diseases
- Peripheral Artery Disease Management
- Cardiac Arrhythmias and Treatments
Sakai Municipal Hospital
2018-2024
Osaka Ekisaikai Hospital
1989-2023
Hiroshima University
2012-2021
Ikeda Municipal Hospital
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2020
ProQuest (United States)
2020
National Cerebral and Cardiovascular Center
2013-2018
Hoshigaoka Medical Center
2016-2018
Japan Community Healthcare Organization
2017-2018
Translational Research Informatics Center (Japan)
2006-2018
The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific dose administered according to Japanese guidelines AF.J-ROCKET was prospective, randomized, double-blind, phase III trial. Patients (n=1,280) non-valvular at increased risk were randomized receive 15 mg or dose-adjusted guidelines. primary objective determine...
We investigated the prevalence of carotid atherosclerosis, including mild early lesions, and its association with cervical bruits various risk factors (age, male sex, hypertension, hyperlipidemia, diabetes mellitus, obesity, cigarette smoking) in 232 consecutive Japanese patients. High-resolution real-time B-mode ultrasonography was performed to determine extent it quantified by using a scoring system. The atherosclerosis 49%, 59%, 41% all patients, 100 symptomatic 132 asymptomatic...
Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence more statins has been established an Asian population. In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese stable coronary artery who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were...
Although the efficacy of anticoagulant therapy for primary prevention stroke in patients with nonvalvular atrial fibrillation (NVAF) has been established, antiplatelet low-risk is disputable Japanese because frequent hemorrhagic complications. We examined and safety aspirin NVAF a prospective randomized multicenter trial.Patients were to an group (aspirin at 150 200 mg per day) or control without therapy. Primary end points included cardiovascular death, symptomatic brain infarction,...
To quantitatively assess atherosclerosis of the carotid artery in subjects with and without diabetes.Ultrasound high resolution B-mode imaging arteries was conducted on 71 nondiabetic hyperlipidemia or hypertension 295 diabetic patients to determine IMT arterial wall.IMT linearly related age (IMT = [0.0087 x age] + 0.3318) [0.0155 0.32450). The regression coefficient for significantly greater than subjects. (mean +/- SD) aged 20-29 that (0.73 0.27 vs. 0.52 0.07 mm, P less 0.01). Multivariate...
Background and Purpose To clarify the clinical significance of carotid atherosclerosis for ischemic stroke events, a follow-up study was performed in Japanese patients. Methods Two hundred fourteen patients were registered from nine hospitals Osaka community. All checked prior history stroke, risk factors evaluated. Carotid assessed by 7.5-MHz duplex ultrasonography. We studied relationship between event rate severity appearance atherosclerosis. also events various factors. Results The...
To elucidate mechanisms underlying neuroprotective properties of astrocytes in brain ischemia, production neurotrophic mediators was studied exposed to hypoxia/reoxygenation (H/R). Rat subjected H/R released increased amounts interleukin (IL) 6 a time-dependent manner, whereas levels tumor necrosis factor and IL-1 remained undetectable. IL-6 transcripts were induced hypoxia the early phase reoxygenation, synthesis release antigen/activity occurred during reoxygenation. Elevated mRNA due, at...
Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic after acute coronary syndrome (ACS) are limited in patients. The objective this study was to clarify long-term outcomes ACS Methods Results: Prevention AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational Consecutive aged ≥20...
Background and Purpose— The primary results of the Japan Adult Moyamoya Trial revealed statistically marginal superiority bypass surgery over medical treatment alone in preventing rebleeding moyamoya disease. purpose this analysis is to test prespecified subgroup hypothesis that natural course surgical effects vary depending on hemorrhagic site at onset. Methods— site, classified as either anterior or posterior, was only stratifying variable for randomization. Statistical analyses were...
BackgroundAlthough statin therapy is beneficial for the prevention of initial stroke, benefit recurrent stroke and its subtypes remains to be determined in Asian, whom profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents recurrence ischemic patients.MethodsThis a multicenter, randomized, open-label, blinded-endpoint, parallel-group patients who experienced non-cardioembolic stroke. All had total cholesterol level between 4.65 6.21...
Background: Edoxaban is a once-daily (QD) oral, direct factor Xa inhibitor in clinical development for the prevention of stroke patients with non-valvular atrial fibrillation (NVAF). The aim this study was to evaluate safety edoxaban Japanese NVAF. Methods and Results: A total 536 NVAF (CHADS2 ≥1) were randomized receive double-blinded 30, 45, or 60mg QD open-label warfarin (international normalized ratio [INR] 2.0-3.0 age <70 years; 1.6-2.6 ≥70 years) 12 weeks. primary endpoint incidence...
The "1-3-6-12-day rule" for starting direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation after acute ischemic stroke or transient attack recommends timings that may be later than used clinical practice. We investigated more practical optimal timing of DOAC initiation according to severity. combined data prospective registries Japan, Stroke Acute Management Urgent Risk-factor Assessment and Improvement-nonvalvular (September 2011 March 2014) RELAXED (February...
To assess the usefulness of transcranial Doppler sonography, we investigated rate blood flow signal recording failure in middle cerebral artery Japanese subjects. Furthermore, studied effect increased emitted power on successful some patients whom had been detected at standard transducer 100 mW/cm2. evaluate recording, measured signals 597 (age range, 16 to 89 years) for screening cerebrovascular disease by using a 2-MHz range-gated, pulsed-wave instrument power. In 18 elderly with power,...
The response of cerebral blood flow to changes in the arterial carbon dioxide partial pressure (i.e., reactivity) has been evaluated as a parameter perfusion reserve patients with cerebrovascular disease. In this study, variations reactivity various ischemic diseases were by newly established method, transcranial Doppler technique.Thirty-three symptomatic disease, 13 asymptomatic infarction, and 25 age-matched normal control subjects investigated. divided into three groups; those unilateral...
BackgroundThe present study tested the hypothesis that inappropriate activation of brain renin-angiotensin system (RA S) contributes to pathogenesis blood-brain barrier (BBB) disruption and cognitive impairment during development salt-dependent hypertension. Effects an angiotensin II (AngII) type-1 receptor blocker (ARB), at a dose did not reduce blood pressure, were also examined.