A5058874508- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Parkinson's Disease and Spinal Disorders
- Peripheral Nerve Disorders
- Antifungal resistance and susceptibility
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Orthopedic Surgery and Rehabilitation
- Autoimmune Neurological Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Multiple Sclerosis Research Studies
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Nerve Injury and Rehabilitation
- Neurological and metabolic disorders
- Multiple Myeloma Research and Treatments
- Diet and metabolism studies
- Brain Metastases and Treatment
- Metabolism and Genetic Disorders
- Legionella and Acanthamoeba research
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and genetic disorders
Hiroshima City Asa Citizens Hospital
2017-2025
Hiroshima University
2013-2025
Kubota (Japan)
2024
Toho University Ohashi Medical Center
2024
Toho University
2024
Tokyo Medical University
2024
Keio University
2024
Citizens Specialty Hospitals
2018-2022
Chugoku Rosai Hospital
2014-2019
Hiroshima University Hospital
2013
Background Early fast-acting treatment (EFT) is the aggressive use of therapies such as plasmapheresis, intravenous immunoglobulin and/or high-dose methylprednisolone (IVMP) from early phases treatment. EFT reportedly beneficial for achievement minimal manifestations (MM) or better status with ≤5 mg/day prednisolone (MM5mg), a practical therapeutic target myasthenia gravis (MG). Objective The current study aimed to clarify which specific regimen efficacious and patient characteristics that...
Efgartigimod, which has been well tolerated and efficacious in individuals with generalized myasthenia gravis (MG), is available Japan not only for the treatment of anti-acetylcholine receptor-positive (AChR+) but also anti-muscle-specific receptor tyrosine kinase (MuSK+) seronegative MG. We report details use efgartigimod MG clinical practice Japan.
Abstract Objective Eculizumab and ravulizumab are complement protein C5 inhibitors, showing efficacy tolerability for patients with anti‐acetylcholine receptor‐positive (AChR+) generalized myasthenia gravis (gMG) in phase 3 clinical trials subsequent analyses. The purpose of the present study was to evaluate significance eculizumab switching refractory AChR+ gMG real‐world experience. Methods Among database Japan MG registry survey 2021, we studied who received eculizumab. We also evaluated...
Myasthenic crisis is a life-threatening exacerbation of myasthenia gravis leading to respiratory failure, while zilucoplan C5 complement inhibitor that prevents complement-mediated destruction the neuromuscular junction, thereby helping restore muscle function and respiration. This case report describes an 85-year-old woman with late-onset who developed myasthenic triggered by aspiration eating. Initial treatment Intravenous immunoglobulin intravenous methylprednisolone showed limited...
Abstract The primary purpose of the Japanese myasthenia gravis registry (JAMG‐R) has been to research and promote high‐quality medical care for MG patients in Japan. We reviewed findings surveys performed by JAMG‐R over an ~10‐y period. first goal favorable quality life (QOL) is a status minimal manifestations (MM) or better with oral prednisolone (PSL) dose 5 mg/d less (MM‐5 mg). E arly aggressive use nonoral f ast‐acting t reatment together low‐dose PSL (the “EFT strategy”) recommended...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder characterized by psychiatric symptoms, seizures, and dyskinesias. This case report describes a 30-year-old woman who was initially suspected of having somatic symptom because the development seizures mimicking psychogenic non-epileptic (PNES). At presentation, she able to engage in conversation follow instructions, but exhibited slight fever, sensory abnormalities, non-stereotypical seizures. Over course two...
Non-motor symptoms in myasthenia gravis (MG) are rarely confirmed. Although there some small cohort studies, a large-systemic survey has not yet been performed.
Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, progenitor cell (EPC) number were patients chronic stroke or risk factors.Patients a history any established factors enrolled study (n=102; 69 men,...
International consensus guidance and Japanese clinical guidelines for myasthenia gravis (MG) recommend achieving minimal manifestations or better status (MM-or-better) as the severity component of treatment goal. However, subjective nature determining MM can result in ambiguity regarding this category practice trials. This study analyzed metrics a large number MG patients to propose criteria MM-or-better. We utilized data obtained from 3800 who participated nationwide cross-sectional surveys...
Abstract Introduction/Aims Cross‐sectional area (CSA) reference values using ultrasonography vary widely for lower extremity peripheral nerves. In addition, there is a lack of data on the muscular branches tibial nerve and anatomical variations sural nerve. We aimed to evaluate ultrasonographic nerves considering different physical factors. Methods The CSA was measured at 10 sites. addition establishing values, differences in owing were verified. relationship between factors, such as age,...
Urine from patients with cerebrotendinous xanthomatosis (CTX) was found to contain a number of minor bile acids along three major acids, 7-epicholic acid, norcholic and cholic acid.The following were identified by combined gas-liquid chromatography-mass spectrometry: 7-ketobisnordeoxycholic acid; 12-ketobisnorchenodeoxycholic 7-ketonordeoxycholic 12-ketochenodeoxycholic 7-ketodeoxycholic bisnorcholic allonorcholic allocholic lphydroxybisnorcholic 10-hydroxynorcholic 16-hydroxycholic...
Neuralgic amyotrophy (NA) is a peripheral nervous system disorder involving multifocal distribution. Although nerve ultrasonography has shown potential for detecting NA lesions, no established detection method exists distal forearm NA. A 59-year-old man presented with weakness of the muscles innervated by left posterior interosseous (PIN), median (MN), anterior (AIN), and ulnar (UN), following severe shoulder pain. This case suggests that can help accurately diagnose