A5074630025- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Cerebrovascular and genetic disorders
- Microbial Natural Products and Biosynthesis
- Neurosurgical Procedures and Complications
- Marine Sponges and Natural Products
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Meningioma and schwannoma management
- Neuropeptides and Animal Physiology
- Spinal Fractures and Fixation Techniques
- Cardiac Arrhythmias and Treatments
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Neurological Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
National Cerebral and Cardiovascular Center
2017-2025
University of Tsukuba Hospital
2024-2025
University of Tsukuba
2025
Toyo University
2024
Kyoto Prefectural University of Medicine
2024
Taipei Veterans General Hospital
2024
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Neurology, Inc
2023
The effect of early as compared with later initiation direct oral anticoagulants (DOACs) in persons atrial fibrillation who have had an acute ischemic stroke is unclear.We performed investigator-initiated, open-label trial at 103 sites 15 countries. Participants were randomly assigned a 1:1 ratio to anticoagulation (within 48 hours after minor or moderate on day 6 7 major stroke) (day 3 4 stroke, 12, 13, 14 stroke). Assessors unaware the trial-group assignments. primary outcome was composite...
Background RING finger protein 213 ( RNF213 ) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension. We hypothesized that insidious abnormal cardiac functions are detected carriers cerebrovascular diseases. Methods Results investigated patients registered the National Cerebral Cardiovascular Center Genome...
ABSTRACT We have isolated four strains of Rhodococcus which specifically degrade estrogens by using enrichment culture activated sludge from wastewater treatment plants. Strain Y 50158, identified as zopfii , completely and rapidly degraded 100 mg 17β-estradiol, estrone, estriol, ethinyl estradiol/liter, demonstrated thin-layer chromatography gas chromatography-mass spectrometry analyses. Strains 50155, 50156, 50157, equi showed degradation activities comparable with that 50158. Using the...
The "1-3-6-12-day rule" for starting direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation after acute ischemic stroke or transient attack recommends timings that may be later than used clinical practice. We investigated more practical optimal timing of DOAC initiation according to severity. combined data prospective registries Japan, Stroke Acute Management Urgent Risk-factor Assessment and Improvement-nonvalvular (September 2011 March 2014) RELAXED (February...
Background: Although tortuosity of the internal carotid artery (ICA) can pose a significant challenge when performing mechanical thrombectomy, few studies have examined impact ICA on thrombectomy outcomes. Methods: In registry-based hospital cohort, consecutive patients with anterior circulation stroke in whom was attempted were divided into 2 groups: those extracranial or cavernous (tortuous group) and without (nontortuous group). The defined as presence coiling kinking. by posterior...
Carotid artery stenosis or occlusion (CASO) is a causative disease of vascular cognitive impairment (VCI) attributed to cerebral hypoperfusion, even without the development symptomatic ischemic stroke. Preclinically, resveratrol has been demonstrated play an important role in improving function rodent CASO models. This study investigated association between long-term intake and improvements hemodynamic impairments patients with CASO.
BACKGROUND: We aimed to examine the boundary of ischemic core volume in patients undergoing endovascular thrombectomy (EVT) versus those receiving medical management determine minimum optimal size for favorable treatment outcomes. METHODS: This is a prespecified substudy RESCUE-Japan LIMIT (Recovery by Endovascular Salvage Cerebral Ultra-Acute Embolism-Japan Large Ischemic Core Trial). Patients with large vessel occlusion were enrolled between November 2018 and September 2021 National...
Early detection of hemorrhagic transformation after reperfusion therapy is crucial in acute stroke treatment. Here, we evaluated the relationship between and post-reperfusion hyperperfusion using pulsed arterial spin labeling (ASL) perfusion MRI 123 I-iodoamphetamine single-photon emission-computed tomography. Patients who developed showed significantly higher cerebral blood flow affected lesion thrombolysis and/or endovascular intervention. Focal (ipsilateral to contralateral ratio >1.5)...
Background Malignant profiles were identified by imaging and unfavorable outcomes that have poor response to reperfusion therapy. Many trials used this profile in their inclusion criteria including large‐vessel occlusion acute ischemic stroke trials. We aimed redefine the cutoff values for malignant patients with regardless of Methods Results Consecutive anterior prospectively extracted from National Cerebral Cardiovascular Center Stroke Registry between March 2014 December 2017....
Background We aimed to identify the large ischemic core (LIC) volume ranges in acute stroke patients that can benefit from mechanical thrombectomy (MT). Methods Consecutive within 24 hours of onset anterior circulation with vessel occlusion and volumes 70–300 mL were included our single-center prospective database March 2014 December 2019. Subjects divided into three groups by baseline (A: 70–100 mL; B: 101–130 C: >130 mL). compared modified Rankin Scale (mRS) score 0–2 at 3 months...
Background and Purpose- The ring finger protein 213 gene ( RNF213) is a susceptibility for moyamoya disease large-artery ischemic stroke in East Asia. We examined the prevalence correlates of RNF213 p.R4810K variant patients with early-onset Japanese single-center cohort. Methods- analyzed 70 intracranial arterial stenosis who developed noncardioembolic or transient attack from 20 to 60 years age. Patients were excluded. Results- was found 17 (24%), more often women than men (38% versus 16%,...
Background and Purpose: Cerebral microbleeds (CMB) are associated with stroke cognitive impairment. We previously reported a high prevalence of CMB in people Streptococcus mutans expressing Cnm, collagen-binding protein the oral cavity. S. is major pathogen responsible for dental caries. Repeated challenge harboring cnm gene encoding Cnm induced cerebral bleeding stroke-prone spontaneously hypertensive rats. The purpose this longitudinal study to examine relationship -positive development...
Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry Japan.
Background and Purpose- We aimed to compare outcomes of ischemic stroke patients with nonvalvular atrial fibrillation between earlier later initiation direct oral anticoagulants (DOACs) after onset. Methods- From data for 1192 acute or transient attack in a prospective, multicenter, observational study, who started DOACs during hospitalization were included divided into 2 groups according median day DOAC Outcomes systemic embolism, major bleeding, death at 3 months, as well those years....
Two new compounds, paecilospirone (1) and phomopsidin (2), seven known chaetoglobosin A (3), griseofulvin (4), fusarielin (5), fusapyrone (6), deoxyfusapyrone (7), verrucarins J (8) L acetate(9), have been isolated characterized from marine-derived fungi collected in tropical sub-tropical coral reef environments. The utility of as a source bioactive secondary metabolites is discussed.
Background and Purpose: Outcomes in patients ≥90 years of age with stroke due to large vessel occlusion were compared between endovascular therapy (EVT) medical management. Methods: Of 2420 acute ischemic a prospective, multicenter, nationwide registry Japan, aged the internal carotid artery or M1 segment middle cerebral included. The primary effectiveness outcome was favorable at 3 months, defined as achieving modified Rankin Scale score 0 2 return least prestroke months. Safety outcomes...
Background We elucidated the safety of treatment with alteplase at 0.6 mg/kg within 24 hours for patients on direct oral anticoagulants (DOACs) before ischemic stroke onset. Methods and Results Consecutive acute who underwent intravenous thrombolysis using from 2011 to 2021 were enrolled our single‐center prospective registry. compared outcomes between taking DOACs those not 48 The primary outcome was rate symptomatic intracranial hemorrhage a ≥4‐point increase National Institutes Health...
Background Carotid artery stenosis or occlusion (CASO) is a major cause of vascular cognitive impairment (VCI). There currently no effective treatment for VCI induced by CASO. Resveratrol, type polyphenol, improves performance in rat CASO models via pleiotropic effects. Furthermore, we previously reported the longevity gene, SIRT1 , which can be activated resveratrol, and cerebral blood flow mouse activating endothelial nitric oxide synthase. However, clinical evidence remains limited....