A5056807475- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Frailty in Older Adults
- Moyamoya disease diagnosis and treatment
- Renal Diseases and Glomerulopathies
- Electrolyte and hormonal disorders
- Nutrition and Health in Aging
- Health and Wellbeing Research
- Musculoskeletal pain and rehabilitation
- Coronary Interventions and Diagnostics
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Potassium and Related Disorders
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intensive Care Unit Cognitive Disorders
- Emergency and Acute Care Studies
National Cerebral and Cardiovascular Center
2018-2025
Zero to Three
2024
Fujita Health University
2018-2023
Osaka University
2013-2020
Brigham and Women's Hospital
2016-2020
Harvard University
2016-2020
Fujita Health University Hospital
2018-2020
Japan Society for the Promotion of Science
2015-2018
Kyoto University
2018
Osaka Health Science University
2015-2017
Background: Reports suggest a relationship between circulating sex hormone levels and breast cancer risk, but genetic association studies have been inconclusive. We investigated the of hormones single nucleotide polymorphisms (SNPs) in genes coding for enzymes that regulate them. Methods: assayed estradiol, testosterone, estrone, androstenedione, 17α-hydroxyprogesterone, hormone–binding globulin (SHBG) 1975 normal postmenopausal women. Fifteen SNPs CYP17, CYP19, EDH17B2, SHBG, COMT, CYP1B1...
Abstract Aims The prognostic value of genetic variants for predicting lethal arrhythmic events (LAEs) in Brugada syndrome (BrS) remains controversial. We investigated whether the functional curation SCN5A variations improves predictability. Methods and results Using a heterologous expression system whole-cell patch clamping, we functionally characterized 22 unknown significance (VUSs) among 55 mutations previously curated using silico prediction algorithms Japanese BrS registry (n = 415)....
Background RING finger protein 213 ( RNF213 ) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension. We hypothesized that insidious abnormal cardiac functions are detected carriers cerebrovascular diseases. Methods Results investigated patients registered the National Cerebral Cardiovascular Center Genome...
The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using twin methodology adjust for genetic factors. BMI UA was investigated in a cross-sectional data from both monozygotic dizygotic twins registered at Osaka University Center Twin Research Graduate School of Medicine. From January 2011 March 2014, 422 individuals participated health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index),...
We investigated whether patients with out-of-hospital cardiac arrest (OHCA) and sustained ventricular fibrillation/pulseless tachycardia (VF/pVT) or conversion to pulseless electrical activity/asystole (PEA/asystole) benefit more from extracorporeal cardiopulmonary resuscitation (ECPR).
Abstract This study aims to develop and validate prediction models for the number of all heatstroke cases, heatstrokes hospital admission death cases per city 12 h, using multiple weather information a population-based database patients in 16 Japanese cities (corresponding around 10,000,000 population size). In testing dataset, mean absolute percentage error generalized linear with wet bulb globe temperature as only predictor optimal models, respectively, are 43.0% 14.8% spikes 37.7% 10.6%...
Although there are regional reports that the COVID-19 pandemic is associated with a reduction in acute myocardial infarction presentations and primary percutaneous coronary intervention (PCI) procedures, little known about impact of on mechanical complications resulting from ST-segment elevation (STEMI) mortality.This single-centre retrospective cohort study analysed presentations, incidence complications, mortality patients STEMI before after state emergency was declared due to by Japanese...
Abstract Low vitamin D levels have been associated with cognitive decline; however, few randomized trials conducted. In a trial, we evaluated D3 supplementation on decline. We included participants aged 60+ years (mean[SD] = 70.9[5.8] years) free of cardiovascular disease and cancer in two substudies the VITAL 2 × trial (2000 IU/day cholecalciferol) fish oil supplements: 3424 had assessments by phone (eight neuropsychologic tests; 2.8 follow-up) 794 in-person (nine 2.0 follow-up). The...
National-level data on trends in the prognosis of age-stratified patients with intracerebral hemorrhage (ICH) are lacking. This study aimed to assess time in-hospital mortality and functional outcomes ICH by sex age, explore factors associated changes trend.
Rationale: An increase of severe ischemic heart diseases results in an the patients with congestive failure (CHF). Therefore, new therapies are expected addition to recanalization coronary arteries. Previous clinical trials using natriuretic peptides (NPs) prove improvement CHF by NPs. Objective: We aimed at investigating whether OSTN (osteocrin) peptide potentially functioning as NPR (NP clearance receptor) 3-blocking can be used a therapeutic for treating after myocardial infarction (MI)...
Adherence to healthy lifestyles/behaviours promotes ageing. However, little is known about whether age, sex and/or race/ethnicity moderate associations of lifestyle/behavioural factors with relative telomere length (RTL), a potential biomarker ageing.We included 749 midlife older non-Hispanic White (n = 254), Black 248) and Hispanic 247) US participants [mean (standard deviation) age 69.3 (7.2) years; women: 50.5%]. We extracted genomic DNA from peripheral leucocytes. RTL was assayed using...
Mitochondrial DNA copy number (mtDNAcn) is a putative biomarker of oxidative stress and biological aging. Modifiable factors, including physical activity (PA), avoidance heavy alcohol use smoking, maintaining good mental health, may reduce promote healthy Yet, limited data exist regarding how these factors are associated with mtDNAcn or whether age, sex race/ethnicity moderate associations. In this cross-sectional study, we selected 391 adults (183 non-Hispanic White, 110 Black 98 Hispanic;...
Recent studies have provided consistent evidence for a genetic influence on chronic widespread pain (CWP). The aim of this study was to investigate (1) the etiological structure underlying CWP by examining covariation between and psychological comorbidities psychoaffective correlates (2) decomposition into environmental components. A total 3266 female twins (mean age 56.6 years) were subject multivariate analyses. Using validated questionnaires classify as having CWP, prevalence 20.8%. In...
Objectives To evaluate a predictive model for robust estimation of daily out-of-hospital cardiac arrest (OHCA) incidence using suite machine learning (ML) approaches and high-resolution meteorological chronological data. Methods In this population-based study, we combined an OHCA nationwide registry datasets from Japan. We developed to predict with training dataset 2005–2013 the eXtreme Gradient Boosting algorithm. A 2014–2015 was used test model. The main outcome accuracy number events,...
Background The role of cyclic guanosine 3′,5′-monophosphate (cGMP) after acute myocardial infarction (AMI) is not well understood despite its significance as a second messenger natriuretic peptides (NPs) in cardiovascular disease. We investigated the association between NP-cGMP cascade and left ventricular reverse remodelling (LVRR) anterior AMI. Methods 67 patients with their first AMI (median age, 64 years; male, 76%) underwent prospective evaluation plasma concentrations molecular forms...
Objective: The growth of unruptured intracranial aneurysms (IAs) is regarded as a critical precursor to aneurysmal rupture. Accurately predicting aneurysm crucial for appropriate therapeutic interventions prevent rupture in high-risk aneurysms. UCAS Japan score has been widely used risk assessment Japan; however, its relationship unclear. present study aimed examine whether the can accurately predict and develop novel prediction system using artificial intelligence (AI)-based machine...
Right ventricular (RV) dysfunction negatively affects mitral valve transcatheter edge-to-edge repair (M-TEER) outcomes in patients with secondary regurgitation (vSMR). However, RV occurs the late phase of heart failure, when it may not respond to interventions. The pulsatile component afterload, pulmonary artery (PA) compliance, is a sensitive parameter that decreases before occurs. We explored utility PA compliance predicting cardiac events after M-TEER. analyzed 107 vSMR who underwent...
The current approach to obesity care, which primarily focuses on weight loss, is often insufficient because of the challenges in maintaining long-term results. Therefore, novel, safe, and sustainable medications for are highly anticipated. Taxifolin, a natural bioactive flavonoid, was found exert pleiotropic protective effects against various diseases. Our experimental vivo vitro studies revealed that taxifolin administration contributes loss. Accordingly, we hypothesized oral intake...
Treatment options for patients with chronic thromboembolic hypertension (CTEPH) have increased over the past decade. However, it is unknown whether outcomes of CTEPH changed as well. This retrospective study analysed data 834 CTEPH, categorised into early (April 1980-December 1999), middle (January 2000-September 2010), and current (October 2010-December 2023) eras. The primary endpoint was all-cause mortality. Multivariable Cox proportional hazards models were used to assess changes in...
Background Our previous preclinical study demonstrated that APOE4 ‐targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment than APOE3 with carotid artery stenosis due to neurovascular dysfunction. Therefore, we clinically investigate whether contributes hemodynamic in subjects asymptomatic or occlusion. Methods Results A cross‐sectional observational was conducted between January 2017 March 2022. In a primary analysis, 91 (114 affected hemispheres)...
In Japan, type 2 diabetes mellitus (T2DM) is a major health concern due to its increasing prevalence and associated complications, including diabetic nephropathy dialysis. Although the positive relationship between annual checkups outcomes well-documented, impact of skipping on T2DM progression dialysis remains unclear. This study aimed explore association frequency DM-related indices potential early intervention in preventing The included citizens aged ≥ 40 years from Nobeoka City, Japan (n...