A5044666284- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Renal and Vascular Pathologies
- Aortic Thrombus and Embolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Procedures and Complications
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Diabetes Treatment and Management
- Diabetes Management and Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
National Cerebral and Cardiovascular Center
2016-2025
Honda (Japan)
2025
Kumamoto University
2005-2024
Otsuka (Japan)
2021-2023
Vanderbilt University Medical Center
2023
Ted Rogers Centre for Heart Research
2023
University Health Network
2023
CVPath Institute
2011-2021
Stanford University
2017
Office of Chief Medical Examiner
2015
Clinical trials have demonstrated that the second-generation cobalt-chromium everolimus-eluting stent (CoCr-EES) is superior to first-generation paclitaxel-eluting (PES) and noninferior or sirolimus-eluting (SES) in terms of safety efficacy. It remains unclear whether vascular responses CoCr-EES are different from those SES PES because pathology has not been described humans.A total 204 lesions (SES=73; PES=85; CoCr-EES=46) 149 autopsy cases with duration implantation >30 days ≤3 years were...
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and mouse model advanced atherosclerosis, investigated intraplaque hemorrhage on function with respect angiogenesis, vascular permeability,...
Recent transcatheter aortic valve replacement studies have raised concerns about adverse cerebrovascular events. The etiopathology of the embolized material is currently unknown.A total 40 patients underwent with use a dual filter-based embolic protection device (Montage Dual Filter System, Claret Medical, Inc). Macroscopic liberated during procedure was captured in filter baskets 30 (75%) and sent for histopathologic analysis. varied size from 0.15 to 4.0 mm. Amorphous calcified (size,...
The internal mammary artery (IMA) grafts have been associated with long-term patency and improved survival as compared to saphenous vein (SVGs). Early failure of IMA is attributed poor surgical technique less thrombosis. Similarly, bypass surgery especially the use has also shown be superior at 1-year well over five years percutaneous procedures, including drug-eluting stents for treatment coronary disease. superiority IMAs SVGs can its striking resistance development atherosclerosis....
Background— The Absorb everolimus-eluting bioresorbable vascular scaffold (Absorb) has shown promising clinical results; however, only limited preclinical data have been published. We sought to investigate detailed pathological responses the versus XIENCE V (XV) in a porcine coronary model with duration of implant extending from 1 42 months. Methods and Results— A total 335 devices (263 72 XV) were implanted 2 or 3 main arteries 136 nonatherosclerotic swine examined by light microscopy,...
The relationships between oxidation-specific epitopes (OSE) and lipoprotein (a) [Lp(a)] progressive atherosclerosis plaque rupture have not been determined. Coronary artery sections from sudden death victims carotid endarterectomy specimens were immunostained for apoB-100, oxidized phospholipids (OxPL), apo(a), malondialdehyde-lysine (MDA), MDA-related detected by antibody IK17 macrophage markers. presence of OxPL captured in saphenous vein graft distal protection devices was determined with...
We recently reported that lowering of macrophage free intracellular iron increases expression cholesterol efflux transporters ABCA1 and ABCG1 by reducing generation reactive oxygen species. In this study, we explored whether levels via pharmacological suppression hepcidin can increase macrophage-specific reduce atherosclerosis.To suppress hepcidin, the exporter ferroportin, iron, used a small molecule inhibitor bone morphogenetic protein (BMP) signaling, LDN 193189 (LDN). (10 mg/kg IP...
AimsRestenosis in drug-eluting stents (DESs) occurs infrequently, however, it remains a pervasive clinical problem. We interrogated our autopsy registry to determine the underlying mechanisms of DES restenosis, and further we investigated neointimal characteristics DESs compared with bare metal (BMSs).