A5018396684- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cancer-related cognitive impairment studies
- Venous Thromboembolism Diagnosis and Management
- Meningioma and schwannoma management
- Atrial Fibrillation Management and Outcomes
- Head and Neck Cancer Studies
- MRI in cancer diagnosis
- Boron Compounds in Chemistry
- Antiplatelet Therapy and Cardiovascular Diseases
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Migration, Health and Trauma
- Radiomics and Machine Learning in Medical Imaging
- Melanoma and MAPK Pathways
- Lanthanide and Transition Metal Complexes
- Torture, Ethics, and Law
- Cardiac Imaging and Diagnostics
- Protease and Inhibitor Mechanisms
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
- Salivary Gland Disorders and Functions
University Medical Center Groningen
2018-2025
University of Groningen
2019-2025
University of Amsterdam
2008-2016
Amsterdam UMC Location University of Amsterdam
2008-2016
University Medical Center Utrecht
2015
Utrecht University
1989
Routine thrombus aspiration is frequently used during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction to prevent distal embolization. Recently, evidence of clinical benefit was published. In 50% the an onset symptoms <12 hours before, thrombi were shown be >1 day old. This observation illustrates that plaque rupture and occlusion are significantly separated time. present study, we correlate presence fresh versus older long-term...
Background— Coronary guidewires are indispensable during percutaneous coronary interventions. Nowadays, most have hydrophilic coatings to improve their trackability, allowing easy lesion passage and facilitating balloon stent positioning. Recent reports, however, raised concerns about detachment subsequent embolization of these coatings. Methods Results— We retrospectively reviewed the histological samples myocardium, obtained autopsies in period 2009 2013, from all patients who had a...
Plaque disruption with superimposed thrombus is the predominant mechanism responsible for onset of acute coronary syndromes. Studies have shown that plaque and thrombotic occlusion are frequently separated in time. We established histopathological characteristics material aspirated during primary percutaneous intervention (PCI) a large consecutive ST-elevation myocardial infarction (STEMI) population.Thrombus aspiration PCI was performed 1,362 STEMI patients. Thrombus age classified as fresh...
Background: Diffusion weighted imaging (DWI) is used for monitoring purposes lower-grade glioma (LGG). While the apparent diffusion coefficient (ADC) clinically used, various DWI models have been developed to better understand micro-environment. However, validity of these and how they relate each other currently unknown. Therefore, this study assesses agreement models. Methods: Fourteen post-treatment LGG patients six healthy controls (HC) underwent MRI on a 3T scanner. processing included...
Abstract Purpose To determine neurocognitive function (NCF) profiles of patients with lower grade glioma (LGG) eligible to undergo proton radiotherapy (PRT), and how these relate clinical radiological characteristics. PRT is offered those for whom sparing NCF considered important given their favorable prognosis. date it unknown which extent are as well. Methods A consecutive cohort 151 LGG according prevailing Dutch criteria, referred between 2018 2023, were assessed standardized...
Purpose: This study aims to create a deep learning (DL) model capable of accurately delineating the ventricles, and by extension, periventricular space (PVS), following 2021 EPTN Neuro-Oncology Atlas guidelines on T1-weighted contrast-enhanced MRI scans (T1CE). The performance this DL was quantitatively qualitatively compared with an off-the-shelf model. Materials Methods: An nnU-Net trained for ventricle segmentation using both CT T1CE images from 78 patients. Its that publicly available...
In patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) thrombus aspiration, the histopathology of aspirated was previously related to long-term mortality. this study, we sought investigate association between and recovery, a marker microvascular dysfunction, immediately at end PCI procedure.We included 892 STEMI who underwent routine aspiration for whom combined data on recovery were available. Patients categorized...
Diffuse low-grade gliomas (dLGG) often have a frontal location, which may negatively affect patients' executive functions (EF). Being diagnosed with dLGG and having to undergo intensive treatment can be emotionally stressful. The ability cope this stress in an adaptive, active flexible way hampered by impaired EF. Consequently, patients suffer from increased mental distress. aim of the present study was explore profiles EF, coping distress identify characteristics each profile.
In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond such as linear energy transfer (LET) raising concerns about increased local potential toxicity. This work aims harmonize quantities for clinical consideration variable therapy. A survey was distributed centres determine agreement on RBE-related implementations. subsequent expert...
In some patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutanous coronary intervention (pPCI) thrombus aspiration, residual stenosis after aspiration is non-significant and additional balloon dilatation or stent placement may be unnecessary. We investigated the angiographic, procedural, clinical outcomes of these in our single center pPCI-database. addition, to gain insight pathological mechanisms thrombosis patients, we established histopathological...
We have previously shown that older thrombus is associated with a twofold higher long-term mortality in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (pPCI). evaluated whether the addition of presence to multimarker model would result increased predictive power for 1-year STEMI patients.The study population (n = 1442) consists treated aspiration during pPCI. Patients were included if aspirated material could histopathologically...
Background and purposeWhen using an immobilization mask, a magnetic resonance imaging (MRI) head receive coil cannot be used patients may experience discomfort during the examination. We therefore wish to assess added value of mask all MRI scans intended for cranial stereotactic radiotherapy (SRT) planning.Materials methodsAn was acquired with without thermoplastic in ten eligible SRT. A planning computed tomography (CT) scan also made, which two MRIs were independently registered....
Novel treatments make long-term survival possible for subsets of patients with melanoma brain metastases. Brain magnetic resonance imaging (MRI) may aid in early detection metastases and inform treatment decisions. This study aimed to determine the impact screening MRI scans metastatic follow-up metastases.This retrospective cohort included diagnosed or between June 2015 January 2018. The was evaluated first 2 years after diagnosis. examined year number scans, scan indications, outcomes,...