A5084949673- Treatment of Major Depression
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Stress Responses and Cortisol
- Mental Health Research Topics
- Diet and metabolism studies
- Complementary and Alternative Medicine Studies
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Alcoholism and Thiamine Deficiency
- Schizophrenia research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Folate and B Vitamins Research
- Fatty Acid Research and Health
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Mindfulness and Compassion Interventions
- Electroconvulsive Therapy Studies
- Medicinal Plant Extracts Effects
- Vitamin D Research Studies
- Pain Management and Placebo Effect
- Psychotherapy Techniques and Applications
- Natural Compound Pharmacology Studies
Massachusetts General Hospital
2016-2025
Harvard University
2015-2024
Uniformed Services University of the Health Sciences
2008-2024
Lemuel Shattuck Hospital
2009-2024
Boston University
1992-2021
Otsuka Pharmaceutical (Spain)
2021
Memorial Foundation
2021
Keio University
2021
Edith Nourse Rogers Memorial Veterans Hospital
2021
National Center for Complementary and Integrative Health
2021
Objective Despite the progressive increase in number of antidepressants, many patients with major depressive disorder continue to be symptomatic. Clearly, there is an urgent need develop better tolerated and more effective treatments for this disorder. The use S-adenosyl methionine (SAMe), a naturally occurring molecule that serves as methyl donor human cellular metabolism, adjunctive treatment antidepressant nonresponders represents one such effort toward novel pharmacotherapy development....
Patients with major depression who have an insufficient response to selective serotonin reuptake inhibitors (SSRIs) may benefit from the addition of 15 mg/day l-methylfolate, only form folate that crosses blood-brain barrier. Adding 7.5 was no more effective than adding placebo, but 15.0 plus ongoing SSRI treatment produced a 32% rate, compared 15% for augmentation placebo. Side effects in two groups were comparable type and frequency.
Background Sleep disturbance (SD) has complex associations with depression, both preceding and following the onset recurrence of depression. We hypothesized that students depressive symptoms SD would demonstrate a greater burden comorbid psychiatric functional impairment compared to without SD. Methods During mental health screening, 287 undergraduate endorsed depression (Beck Depression Inventory [BDI] ≥ 13) filled out self-report measures: demographic questionnaire, BDI, Anxiety Symptom...
Major depressive disorder (MDD) is a leading global cause of disability, and current antidepressant treatments remain inadequate for many patients. Emerging evidence highlights the role inflammation in pathophysiology depression, offering novel therapeutic target. Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty (n-3 PUFA) with potent anti-inflammatory pro-resolving effects, shows promise as adjunctive treatment depression. This article examines rationale behind EPA's effects...
Previous investigations have shown that culture of freshly isolated hepatocytes under conventional conditions, i.e., on dried rat tail collagen in the presence growth factors, facilitates cell but also causes an extensive down-regulation most liver-specific functions. This dedifferentiation process can be prevented if cells are cultured a reconstituted basement membrane gel matrix derived from Englebreth-Holm-Swarm mouse sarcoma tumor (EHS gel). To gain insight into mechanisms regulating...
We sought to determine whether maca, a Peruvian plant, is effective for selective‐serotonin reuptake inhibitor (SSRI)‐induced sexual dysfunction. conducted double‐blind, randomized, parallel group dose‐finding pilot study comparing low‐dose (1.5 g/day) high‐dose (3.0 maca regimen in 20 remitted depressed outpatients (mean age 36 ± 13 years; 17 women) with SSRI‐induced The Arizona Sexual Experience Scale (ASEX) and the Massachusetts General Hospital Function Questionnaire (MGH‐SFQ) were used...
Body awareness has been proposed as one of the major mechanisms mindfulness interventions, and it shown that chronic pain depression are associated with decreased levels body awareness. We investigated effect Mindfulness-Based Cognitive Therapy (MBCT) on in patients comorbid active compared to treatment usual (TAU; N = 31). was measured by a subset Multidimensional Assessment Interoceptive Awareness (MAIA) scales deemed most relevant for population. These included: Noticing, Not-Distracting,...
Article Abstract Objective: To examine the comparative antidepressant efficacy of S-adenosyl-l-methionine (SAMe) and escitalopram in a placebo-controlled, randomized, double-blind clinical trial. Method: One hundred eighty-nine outpatients (49.7% female, mean age = 45 years) with DSM-IV-diagnosed major depressive disorder (MDD) were recruited from April 13, 2005, to December 22, 2009, at Massachusetts General Hospital Butler Hospital. Patients randomized for 12 weeks SAMe 1,600-3,200 mg/d,...