A5005971302- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Face Recognition and Perception
- Mental Health Treatment and Access
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Resilience and Mental Health
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- COVID-19 and Mental Health
- Obsessive-Compulsive Spectrum Disorders
- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Evolutionary Psychology and Human Behavior
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Athinoula A. Martinos Center for Biomedical Imaging
2015-2025
McLean Hospital
2022-2023
San Francisco VA Health Care System
2023
University of Pennsylvania
2023
Karolinska Institutet
2023
Yale University
2023
Harvard University Press
2008-2022
Brigham and Women's Hospital
2022
Background Sleep disturbance (SD) has complex associations with depression, both preceding and following the onset recurrence of depression. We hypothesized that students depressive symptoms SD would demonstrate a greater burden comorbid psychiatric functional impairment compared to without SD. Methods During mental health screening, 287 undergraduate endorsed depression (Beck Depression Inventory [BDI] ≥ 13) filled out self-report measures: demographic questionnaire, BDI, Anxiety Symptom...
The striatum of the human brain has a highly differentiated neurochemical architecture visible in stains for many neurotransmitter-related molecules present striatum. distributions these chemical markers have never been analyzed comprehensively. We compared multiple serial-section analysis caudate nucleus, putamen, and ventral normal brains. cholinergic system was identified with choline acetyltransferase (ChAT). organization fiber that striatal systems expressing immunoreactivity calbindin...
Volume deficits of the hippocampus in schizophrenia have been consistently reported. However, is anatomically heterogeneous; it remains unclear whether certain portions are affected more than others schizophrenia. In this study, we aimed to determine volume confined specific subfields and measure subfield trajectories over course illness. Magnetic resonance imaging scans were obtained from Data set 1: 155 patients with (mean duration illness 7 years) 79 healthy controls, 2: an independent...
<b><i>Background/Aims:</i></b> Suicide is one of the leading causes death in college students and often associated with depression. The aim this study was to assess rates suicidal ideation (SI) on campuses identify its correlates. <b><i>Methods:</i></b> On-campus depression screening sessions were conducted at 3 universities (n = 898; 55% female; mean age 20.07 ± 1.85 years). Participants completed Beck Depression Inventory (BDI; SD total score...
The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning extinction, brain regions known to be sexually dimorphic. We used functional magnetic resonance imaging (fMRI) investigate sex differences activity these during extinction.Subjects were 12 healthy men comparable women who underwent a 2-day experiment 3 T MR scanner. Fear extinction learning occurred on day 1 recall 2. conditioned stimuli visual cues the unconditioned...
Hemispheric specialization of the human brain is a marker successful neurodevelopment. Altered asymmetry that has been repeatedly reported in schizophrenia may represent consequences disrupted neurodevelopment disorder. However, complete picture functional schizophrenic and its connectional substrates yet to be unveiled.
Context: Abnormalities in associative memory processes, such as Pavlovian fear conditioning and extinction, have been observed schizophrenia.The retrieval of extinction memories (safety signals) may be particularly affected; although schizophrenic patients can extinguish conditioned fear, they show a deficit retrieving after delay.The neurobiological basis this abnormality is unknown, but clues emerged from studies rodents humans demonstrating that the ventromedial prefrontal cortex (vmPFC)...
A parietal-frontal network in primates is thought to support many behaviors occurring the space around body, including interpersonal interactions and maintenance of a particular "comfort zone" or distance from other people ("personal space"). To better understand this humans, we used functional MRI measure responses moving objects (faces, cars, simple spheres) connectivity two regions network, dorsal intraparietal sulcus (DIPS) ventral premotor cortex (PMv). We found that both areas...
Abstract Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine whether cortical thickness (CTh) in schizophrenia relates interregional variation distinct neural cell types, as inferred from established gene expression data person-specific genomic variation. This study comprised 1849 participants total, including a discovery (140 cases 1267 controls) validation...
The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and brain's response to peripheral events. Its upregulation enlargement are considered essential in psychosis. However, timing ChP has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method examine volumes two cohorts individuals with first sample consists 41 early course psychosis (mean duration illness = 1.78 years) 30 healthy...
Rates of loneliness and other forms social disconnection have been increasing worldwide. Prior studies suggested that brief behavioral interventions can teach skills may improve functioning connection but, currently, access to such is limited. One previously untested approach for addressing this gap these using immersive, multi-user virtual reality (VR). To measure the feasibility approach, 33 young adults experiencing discomfort were enrolled in a study VR-based application called...
Abstract Although the neurocognitive mechanisms of nonaffective language comprehension have been studied extensively, relatively less is known about how emotional meaning processed. In this study, electrophysiological responses to affectively positive, negative, and neutral words, presented within nonconstraining, contexts, were evaluated under conditions explicit evaluation content (Experiment 1) passive reading 2). both experiments, a widely distributed Late Positivity was found be larger...
Context: Loosening of associations has long been considered a core feature schizophrenia, but its neural correlate remains poorly understood.Objective: To test the hypothesis that, in comparison with healthy control subjects, patients schizophrenia show increased activity within inferior prefrontal and temporal cortices response to directly indirectly semantically related (relative unrelated) words.Design: A functional neuroimaging study using semantic priming paradigm.
An intriguing region of human visual cortex (the fusiform face area; FFA) responds selectively to faces as a general higher-order stimulus category. However, the potential role lower-order properties in FFA remains incompletely understood. To clarify those lower-level influences, we measured responses independent variation 4 dimensions using standardized stimuli and functional Magnetic Resonance Imaging (fMRI). These were size, position, contrast, rotation depth (viewpoint). We found that...
Most individuals identified as ultra-high-risk (UHR) for psychosis do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on fully remit. Prior work has shown that the volume of CA1, a subfield hippocampus, is selectively reduced in early stages schizophrenia. Here we aimed determine whether patterns change CA1 are different UHR who achieve symptomatic remission. Structural MRI scans were acquired at baseline and 1–2 follow-up time points (at 12-month...