A5035934475- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Face Recognition and Perception
- Radiology practices and education
- Toxic Organic Pollutants Impact
- Children's Physical and Motor Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hepatitis C virus research
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Economic and Environmental Valuation
- Heart Rate Variability and Autonomic Control
- HIV/AIDS drug development and treatment
- Obsessive-Compulsive Spectrum Disorders
- Inclusion and Disability in Education and Sport
- Neurotransmitter Receptor Influence on Behavior
- Systemic Lupus Erythematosus Research
- Cardiovascular Health and Disease Prevention
- Effects and risks of endocrine disrupting chemicals
- Blood Pressure and Hypertension Studies
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Innovations in Medical Education
- Computational Drug Discovery Methods
University of Victoria
2020-2025
Daemen College
2024
University of Exeter
2018-2022
University of Newcastle Australia
2020
University of Alberta
2020
Scottish Power (United Kingdom)
2019
Montana State University
2018
University of New Hampshire
2018
Louisiana Department of Natural Resources
2018
Amsterdam Neuroscience
2018
Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable vivo using magnetic resonance imaging. It not clear whether abnormalities cortical anatomy AD can be reliably measured across different subject samples, how closely they track symptoms, are prior to symptoms. An exploratory map thinning mild was used define interest that were applied a hypothesis-driven fashion other samples. Results demonstrate...
Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex during the symptomatic state in posttraumatic stress disorder (PTSD).To determine whether these abnormalities also occur response to overtly presented affective stimuli unrelated trauma; examine relationship between their PTSD symptom severity stimuli; responsivity of regions habituates normally across repeated stimulus presentations PTSD.Case-control...
Patients with chronic infection hepatitis C virus (HCV) genotype 1 often need 48 weeks of peginterferon–ribavirin treatment for a sustained virologic response. We designed noninferiority trial (noninferiority margin, −10.5%) to compare rates response among patients receiving two durations.
Functional magnetic resonance imaging (fMRI) of the human brain was used to compare changes in amygdala activity associated with viewing facial expressions fear and anger. Pictures faces bearing or anger, as well neutral expressions, were presented 8 healthy participants. The blood oxygen-level dependent (BOLD) fMRI signal within dorsal significantly greater Fear versus Anger, a direct contrast. Significant BOLD ventral observed contrasts Neutral and, more spatially circumscribed region,...
Repeated presentations of emotional facial expressions were used to assess habituation in the human brain using fMRI. Significant fMRI signal decrement was present left dorsolateral prefrontal and premotor cortex, right amygdala. Within cortex greater happy vs fearful stimuli evident, suggesting devotion sustained neural resources for processing threat safety signals. In amygdala, significantly observed on compared left. contrast, amygdala more activated than contrast fear happy. We...
Infants with an inhibited temperament tend to develop into children who avoid people, objects, and situations that are novel or unfamiliar, whereas uninhibited spontaneously approach persons, situations. Behavioral physiological features of these two temperamental categories moderately stable from infancy early adolescence have been hypothesized be due, in part, variation amygdalar responses novelty. We found adults had categorized the second year life as inhibited, compared those previously...
Abstract Butyrylcholinesterase (BChE) and an altered form of acetylcholinesterase (AChE) accumulate in the plaques tangles Alzheimer's disease (AD). The sources for these plaque‐ tangle‐bound cholinesterases have not been identified. We now report that AChE BChE activities with pH preferences inhibitor selectivities identical to those are found astrocytes oligodendrocytes control AD brains. These glial‐type selectively inhibited by indolamines protease inhibitors. In brains appear confined...
Introversion/extraversion and neuroticism are 2 important frequently studied dimensions of human personality. These describe individual differences in emotional responding across a range situations may contribute to predisposition for psychiatric disorders. Recent neuroimaging research has begun provide evidence that introversion/extraversion have specific functional structural neural correlates. Previous studies healthy adults reported an association between neuroticism,...
Neuroimaging studies using angry or contemptuous human facial photographic stimuli have suggested amygdala hyper-responsivity in social anxiety disorder (SAD). We sought to determine if an "schematic face" (simple line drawing) would evoke exaggerated amygdalar responses SAD patients compared with healthy control (HC) subjects. Angry, happy, and neutral schematic faces were overtly presented matched cohorts of 11 HC subjects for passive viewing, whereas brain functional magnetic resonance...
Abstract In the rat, fibers from prelimbic cortex terminate in medial nucleus accumbens. Anterior paraventricular thalamic and parvicellular basal amygdaloid reach both All three afferent systems have an inhomogeneous distribution within accumbens, whether or not these projections actually same areas is unknown. Our aim was to evaluate relationships of afferents with respect shell, core, cell clusters Double anterograde tracing single combined immunohistochemistry for calbindin (D28k) Nissl...