Sylvain Bouix
A5002424091- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Medical Image Segmentation Techniques
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Schizophrenia research and treatment
- Morphological variations and asymmetry
- Tensor decomposition and applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Congenital heart defects research
- 3D Shape Modeling and Analysis
- Image Retrieval and Classification Techniques
- Color Science and Applications
- Atomic and Subatomic Physics Research
- Advanced Vision and Imaging
- Cell Image Analysis Techniques
- Medical Imaging and Analysis
- Coronary Artery Anomalies
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Cardiac Arrest and Resuscitation
- Neuroscience and Music Perception
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
École de Technologie Supérieure
2022-2025
Université du Québec à Montréal
2023-2025
New York University
2024
Boston University
2004-2024
Alzheimer's Association
2024
Cognitive Neuroimaging Lab
2007-2023
Landscape Research Group
2023
VA San Diego Healthcare System
2023
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what believe is first ever large-scale coordinated study WM microstructural differences schizophrenia. Our analysis consisted 2359 healthy controls 1963 patients from 29 independent international studies; harmonized processing statistical analyses...
Diffusion MRI has been successful in identifying the existence of white matter abnormalities schizophrenia vivo. However, role these etiology is not well understood. Accumulating evidence from imaging, histological, genetic, and immunochemical studies support involvement axonal degeneration neuroinflammation--ubiquitous components neurodegenerative disorders--as underlying pathologies abnormalities. Nevertheless, current imaging modalities cannot distinguish neuroinflammation degeneration,...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Clinical ascertainment and clinical outcome are key features of any large multisite study. In the ProNET PRESCIENT research networks, Accelerating Medicines Partnership® Schizophrenia (AMP®SCZ) Ascertainment Outcome Measures Team aimed to establish a harmonized assessment protocol across these two networks define criteria primary secondary endpoints. addition developing protocol, goals this aspect AMP SCZ project were: (1) implement monitor training, participants, assessments; (2) provide...
Cognitive impairment occurs at higher rates in individuals clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance multivariate prediction models of transition psychosis. Such is considered a core biomarker schizophrenia. Thus, cognition key domain measured the Accelerating Medicines Partnership® program Schizophrenia (AMP SCZ initiative). The aim this paper describe rationale, processes, considerations, final harmonization cognitive battery used...
Abstract Neuroimaging with MRI has been a frequent component of studies individuals at clinical high risk (CHR) for developing psychosis, goals understanding potential brain regions and systems impacted in the CHR state identifying prognostic or predictive biomarkers that can enhance our ability to forecast outcomes. To date, most involving are likely not sufficiently powered generate robust generalizable neuroimaging results. Here, we describe prospective, advanced, modern protocol was...
Abstract Modern research management, particularly for publicly funded studies, assumes a data governance model in which grantees are considered stewards rather than owners of important sets. Thus, there is an expectation that collected shared as widely possible with the general community. This presents problems complex studies involve sensitive health information. The latter requires balancing participant privacy needs Here, we report on operation ecosystem crafted Accelerating Medicines...
Youth football players may incur hundreds of repetitive head impacts (RHI) in one season. Our recent research suggests that exposure to RHI during a critical neurodevelopmental period prior age 12 lead greater later-life mood, behavioral, and cognitive impairments. Here, we examine the relationship between first (AFE) through tackle corpus callosum (CC) microstructure using magnetic resonance diffusion tensor imaging (DTI). Forty retired National Football League (NFL) players, ages 40-65,...
In healthy adult individuals, late life is a dynamic time of change with respect to the microstructural integrity white matter tracts. Yet, elderly individuals are generally excluded from diffusion tensor imaging studies in schizophrenia. Therefore, we examined frontotemporal and interhemispheric tracts schizophrenia across lifespan. Diffusion data 25 younger schizophrenic patients (≤55 years), controls, older (≥56 years) controls were analysed. Patients each group individually matched...
Background Patients with schizophrenia (SZ) characteristically exhibit supranormal levels of cortical activity to self-induced sensory stimuli, ostensibly because abnormalities in the neural signals (corollary discharges, CDs) normatively involved suppressing consequences self-generated actions. The nature these is unknown. This study investigated whether SZ patients experience CDs that are abnormally delayed their arrival at cortex. Method Twenty-one and 25 matched control participants...
A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology these and there often no radiological evidence based on conventional clinical imaging. We aimed to utilize methods evaluate microstructural tissue changes determine whether or not a link PPCS was present. novel analysis method developed identify abnormalities in high-resolution diffusion tensor imaging (DTI) when...
Abstract Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine whether cortical thickness (CTh) in schizophrenia relates interregional variation distinct neural cell types, as inferred from established gene expression data person-specific genomic variation. This study comprised 1849 participants total, including a discovery (140 cases 1267 controls) validation...
Abstract Aim To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome psychosis (CHR‐P): Structured Interview Psychosis‐risk Syndromes (SIPS) Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods The initial workshop is described in companion report from Addington et al. After workshop, lead experts each instrument continued harmonizing attenuated positive symptoms criteria CHR‐P through an intensive series joint...
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) project assesses a large sample of individuals at clinical high-risk for developing psychosis (CHR) and community controls. Subjects are enrolled in 43 sites across 5 continents. assessments include domains similar to those acquired previous CHR studies along with novel that collected longitudinally period 2 years. In parallel the data acquisition, multidisciplinary teams experts have been working formulate analysis strategy...