A5011260701- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Neuroscience and Music Perception
- Hallucinations in medical conditions
- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Obsessive-Compulsive Spectrum Disorders
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Mental Health Treatment and Access
- Neural and Behavioral Psychology Studies
- Color perception and design
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Psychedelics and Drug Studies
- Advanced Neuroimaging Techniques and Applications
- Pain Management and Placebo Effect
- Psychology of Moral and Emotional Judgment
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
Yale University
2016-2025
Connecticut Mental Health Center
2017-2025
University of North Carolina at Chapel Hill
2025
University Hospital Heidelberg
2022
Heidelberg University
2022
Aalborg University
2022
Bernstein Center for Computational Neuroscience Heidelberg-Mannheim
2022
Jonas (United States)
2022
University of Bergen
2018
John F. Kennedy Center for the Performing Arts
2016
Neural mechanisms for hallucinations Pairing a stimulus in one modality (vision) with another (sound) can lead to task-induced healthy individuals. After many trials, people eventually report perceiving nonexistent contingent on the presence of previously paired stimulus. Powers et al. investigated how different groups volunteers and patients respond this conditioning paradigm. They used behavior, neuroimaging, computational modeling dissect effect perceptual priors versus sensory evidence...
The brain's ability to bind incoming auditory and visual stimuli depends critically on the temporal structure of this information. Specifically, there exists a window audiovisual integration within which are highly likely be bound together perceived as part same environmental event. Several studies have described bounds window, but few investigated its malleability. Here, plasticity in size was using perceptual learning paradigm participants were given feedback during two-alternative forced...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Clinical ascertainment and clinical outcome are key features of any large multisite study. In the ProNET PRESCIENT research networks, Accelerating Medicines Partnership® Schizophrenia (AMP®SCZ) Ascertainment Outcome Measures Team aimed to establish a harmonized assessment protocol across these two networks define criteria primary secondary endpoints. addition developing protocol, goals this aspect AMP SCZ project were: (1) implement monitor training, participants, assessments; (2) provide...
Abstract Neuroimaging with MRI has been a frequent component of studies individuals at clinical high risk (CHR) for developing psychosis, goals understanding potential brain regions and systems impacted in the CHR state identifying prognostic or predictive biomarkers that can enhance our ability to forecast outcomes. To date, most involving are likely not sufficiently powered generate robust generalizable neuroimaging results. Here, we describe prospective, advanced, modern protocol was...
The brain's ability to bind incoming auditory and visual stimuli depends critically on the temporal structure of this information. Specifically, there exists a window audiovisual integration within which are highly likely be perceived as part same environmental event. Several studies have described bounds window, but few investigated its malleability. Recently, our laboratory has demonstrated that perceptual training paradigm is capable eliciting 40% narrowing in width stable for at least 1...
Abstract Hearing voices that are not present is a prominent symptom of serious mental illness. However, these experiences may be common in the non-help-seeking population, leading some to propose existence continuum psychosis from health disease. Thus far, research on this has focused what impaired help-seeking groups. Here we focus protective factors voice-hearers. We introduce new study population: clairaudient psychics who receive daily auditory messages. conducted phenomenological...
<b><i>Background:</i></b> Ketamine, the NMDA glutamate receptor antagonist drug, is increasingly employed as an experimental model of psychosis in healthy volunteers. At subanesthetic doses, it safely and reversibly causes delusion-like ideas, amotivation perceptual disruptions reminiscent aberrant salience experiences that characterize first-episode psychosis. However, auditory verbal hallucinations, a hallmark symptom schizophrenia, have not been reported...
Abstract “Resting‐state” functional magnetic resonance imaging (rs‐fMRI) is widely used to study brain connectivity. So far, researchers have been restricted measures of connectivity that are computationally efficient but undirected, or effective estimates directed limited small networks. Here, we show a method recently developed for task‐fMRI—regression dynamic causal modeling (rDCM)—extends rs‐fMRI and offers both directional scalability whole‐brain First, simulations demonstrate rDCM...
Progressive grey matter loss has been demonstrated among clinical high-risk (CHR) individuals who convert to psychosis, but it is unknown whether these changes occur prior psychosis onset. Identifying illness-related neurobiological mechanisms that conversion essential for targeted early intervention. Among participants in the third wave of North American Prodrome Longitudinal Study (NAPLS3), this report investigated if steeper cortical thinning was observable onset CHR ultimately converted...
Abstract Aim To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome psychosis (CHR‐P): Structured Interview Psychosis‐risk Syndromes (SIPS) Comprehensive Assessment of At‐Risk Mental States (CAARMS). Methods The initial workshop is described in companion report from Addington et al. After workshop, lead experts each instrument continued harmonizing attenuated positive symptoms criteria CHR‐P through an intensive series joint...
Abstract Life in a multisensory world requires the rapid and accurate integration of stimuli across different senses. In this process, temporal relationship between is critical determining which share common origin. Numerous studies have described binding window—the time window within audiovisual are likely to be perceptually bound. addition characterizing window’s size, recent work has shown it malleable, with capacity for substantial narrowing following perceptual training. However,...
More than 20 years after the clinical high risk syndrome for psychosis (CHR) was first articulated, it remains controversial whether CHR predicts onset of with diagnostic specificity or pluripotential outcomes. Recently, analyses observational studies, however, have suggested that is not emergent The present report conducted additional in previously reported samples to determine (1) comorbid disorders were more likely persist patients compared a comparison group who responded recruitment...
Visual hallucinations have haunted humanity for millennia. While our explanations these phenomena are now more soundly based in neuroscience, understanding of their provenance remains superficial. In particular, the role specific visual system disruptions generation unclear. We and others recently demonstrated that psychosis-spectrum illness can be engendered by over-weighting expectations during perception. Emerging evidence suggests this state affairs is also true other neuropsychiatric...