A5004943204- Schizophrenia research and treatment
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Music and Audio Processing
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health Treatment and Access
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Tryptophan and brain disorders
- Action Observation and Synchronization
- Epilepsy research and treatment
- Cognitive Abilities and Testing
Yale University
2015-2024
Sage Therapeutics (United States)
2023-2024
VA Connecticut Healthcare System
2009-2020
Connecticut Mental Health Center
2017
Rehabilitation Research and Development Service
2011
Indiana University
2009
Indiana University – Purdue University Indianapolis
2005-2008
University of Indianapolis
2005-2006
Impairments in laboratory tasks of metacognition appear to be associated with symptoms, functioning, and neurocognition schizophrenia. We sought replicate these results a study within personal narratives self illness.Narratives 61 men schizophrenia were rated using the Metacognition Assessment Scale correlated concurrent assessment quality life, insight.Controlling for age education, understanding one's own mind was linked better across multiple domains, lesser emotional withdrawal. Greater...
With millisecond-level resolution, electroencephalographic (EEG) recording provides a sensitive tool to assay neural dynamics of human cognition. However, selection EEG features used answer experimental questions is typically determined priori. The utility machine learning was investigated as computational framework for extracting the most relevant from data empirically. Schizophrenia (SZ; n = 40) and healthy community (HC; 12) subjects completed Sternberg Working Memory Task (SWMT) during...
<h3>Importance</h3> Although clinical criteria for identifying youth at risk psychosis have been validated, they are not sufficiently accurate predicting outcomes to inform major treatment decisions. The identification of biomarkers may improve outcome prediction among individuals high (CHR-P). <h3>Objective</h3> To examine whether mismatch negativity (MMN) event–related potential amplitude, which is deficient in schizophrenia, reduced young people with the CHR-P syndrome and associated...
Social cognitive impairments and negative symptoms are core features of schizophrenia closely associated with impaired community functioning. However, little is known about whether these independent dimensions illness if so, individuals can be meaningfully classified based on (SANS) potentially differentially treated. Five social measures plus Scale for the Assessment Negative Symptoms Positive Syndrome (PANSS) scores in a sample 77 outpatients produced 2 distinct factors--a factor symptom...
In most patients, a prodromal period precedes the onset of schizophrenia. Although clinical criteria for identifying psychosis risk syndrome (PRS) show promising predictive validity, assessment neurophysiologic abnormalities in at-risk individuals may improve prediction and clarify pathogenesis schizophrenia.To determine whether P300 event-related potential amplitude, which is deficient schizophrenia, reduced PRS associated with outcomes.Auditory data were collected as part multisite,...
Complexity and lack of standardization have mostly limited the use event-related potentials (ERPs) quantitative EEG (QEEG) biomarkers in drug development to small early phase trials. We present results from a clinical study on healthy volunteers (HV) patients with schizophrenia (SZ) that assessed test-retest, group differences, variance, correlation functional assessments for ERP QEEG measures collected at commercial trial sites standardized instrumentation methods, analyzed through an...
Background: The utility of an endophenotype depends on its ability to reduce complex disorders into stable, genetically linked phenotypes. P50 and P300 event-related potential (ERP) measures are candidates for schizophrenia; however, their abnormalities broadly observed across neuropsychiatric disorders. This study examined the diagnostic efficiency in schizophrenia as compared with healthy bipolar disorder samples. Supplemental ERP a multivariate classification approach were evaluated...
More than 20 years after the clinical high risk syndrome for psychosis (CHR) was first articulated, it remains controversial whether CHR predicts onset of with diagnostic specificity or pluripotential outcomes. Recently, analyses observational studies, however, have suggested that is not emergent The present report conducted additional in previously reported samples to determine (1) comorbid disorders were more likely persist patients compared a comparison group who responded recruitment...
Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features...
Controversy exists regarding whether awareness of schizophrenia is linked with healthier or poorer psychosocial function. This study examined hope might interact insight to affect function at the level active versus avoidant coping preferences among 96 persons spectrum disorders. Factorial multivariate analysis variance comparing groups classified on basis and scores revealed a significant interaction between (Wilks λ = 2.7; p< 0.05). Post hoc analyses indicated that high demonstrated most...
Objectives: Accumulating research implicates the cerebellum in non‐motor psychological processes and psychiatric diseases, including bipolar disorder (BD). Despite recent evidence that cerebellar lesions have been documented to trigger bipolar‐like symptoms, few studies directly examined functional integrity of those afflicted with BD. Methods: Using a single‐cue delay eyeblink conditioning procedure, was 28 individuals BD (9 manic, 8 mixed, 11 euthymic) age‐matched healthy controls....
This study aimed to establish concordance between phenomenological and psychophysiological indices of sensory gating disturbance in schizophrenia. Perceptually normal deviant subgroups schizophrenia (SZ) healthy comparison (HC) participants were empirically determined on the basis self-rated Sensory Gating Inventory scores. Contrasts by diagnosis subgroup classification conducted event-related brain potential (ERP) response attenuation paired auditory stimuli, measured time (P50 ERP)...
The mismatch negativity (MMN) event-related potential (ERP) component is increasingly viewed as a prediction error signal elicited when deviant sound violates the that frequent "standard" will repeat. Support for this predictive coding framework emerged with identification of repetition positivity (RP), standard stimulus ERP increases and thought to reflect strengthening standard's memory trace associated code. Using electroencephalographic recordings, we examined RP by repeating tones...
Background. To help mitigate empirically-identified shortcomings in Supported Employment (SE) outcomes for consumers with severe mental illness Indiana (e.g., few long-term placements), Vocational Rehabilitation Services (VRS) and the Division of Mental Health Addictions (DMHA) proposed implementation a results-based funding (RBF) system, which providers received payment only when clients successfully attained each 5 employment milestones. The current study presents results multi-site...
Although supported employment (SE) helps most individuals with mental illness find employment, many continue to face significant barriers achieving their vocational goals. In this 12-month prospective study, consumer perceptions of illness-related (e.g., medication side effects) and common transportation) were assessed in relation work rehabilitation outcomes. At the time SE enrollment, endorsement correlated negatively hopefulness quality life, whereas clinician ratings independent...