A5032459295- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Hemispheric Asymmetry in Neuroscience
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Mental Health Research Topics
- Spatial Neglect and Hemispheric Dysfunction
- Neurobiology of Language and Bilingualism
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Cognitive Abilities and Testing
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Dementia and Cognitive Impairment Research
- Neuroscience, Education and Cognitive Function
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Psychotherapy Techniques and Applications
- EEG and Brain-Computer Interfaces
Yale University
2015-2024
Connecticut Mental Health Center
2004-2020
New Haven Public Schools
2020
VA Connecticut Healthcare System
2003-2014
Hartford Hospital
2013
Emory University
2008
University of California, San Francisco
2000
San Francisco VA Medical Center
2000
Saigata National Hospital
1994
National Institute of Neurological Disorders and Stroke
1994
OBJECTIVE: Identification of brain activity associated with craving is important for understanding the neurobiology addiction. METHOD: Brain was measured in cocaine addicts and healthy subjects by functional magnetic resonance imaging (fMRI) while watched videotapes designed to elicit happy feelings, sad or desire use cocaine. The indicated onset drug emotional response, allowing comparison groups before after such feelings. RESULTS: Robust activation anterior cingulate evident patients...
Background: Gambling urges in pathological gambling (PG) often immediately precede engagement selfdestructive behavior.An improved understanding of the neural correlates PG would advance our brain mechanisms underlying and help direct research into effective treatments.Methods: Echoplanar functional magnetic resonance imaging was used to assess function during viewing videotaped scenarios with gambling, happy, or sad content.Participants rated quality magnitude their emotional motivational...
<h3>Background</h3> Cognitive deficits are a major determinant of social and occupational dysfunction in schizophrenia. In this study, we determined whether neurocognitive enhancement therapy (NET) combination with work (WT) would improve performance on neuropsychological tests related to but different from the training tasks. <h3>Methods</h3> Sixty-five patients schizophrenia or schizoaffective disorder were randomly assigned NET plus WT alone. Neurocognitive included computer-based...
<h3>Background</h3> Cigarette smoking rates in schizophrenia are higher than the general population. <h3>Objectives</h3> To determine whether cigarette modifies cognitive deficits and to establish role of nicotinic acetylcholine receptors (nAChRs) mediating smoking–related enhancement. <h3>Design</h3> Neuropsychological assessments were performed at baseline, after overnight abstinence, reinstatement across 3 separate test weeks during which subjects pretreated a counterbalanced manner with...
Functional magnetic resonance imaging (fMRI) was used to study activation changes in the human primary motor-sensory areas (MAs), supplementary motor (SMAs), premotor (PMAs) and superior inferior parietal (SPAs, IPAs) during right hand finger movements as rate, force complexity of movement were varied. A preliminary reproducibility a single subject doing same repetitive index nine different sessions over six week period demonstrated highly consistent localized contralateral MA. ANOVAs...
<h3>Background</h3> Verbal learning and memory deficits are among the most severe cognitive observed in schizophrenia. We have demonstrated that such do not extend to working for tones a substantial number of patients even when verbal is impaired. In this study we used functional magnetic resonance imaging neural basis dissociation auditory nonverbal individuals with <h3>Methods</h3> While undergoing imaging, 12 schizophrenic matched control subjects performed Word Serial Position Task Tone...
Choice Outstanding Academic Title, 2007. Research shows that between birth and early adulthood the brain requires sensory stimulation to develop physically. The nature of shapes connections among neurons create neuronal networks necessary for thought behavior. By changing cultural environment, each generation brains next. adulthood, neuroplasticity is greatly reduced, this leads a fundamental shift in relationship individual environment: during first part life, mind shape themselves major...
Over the recent years there has been a growing debate regarding extent and nature of overlap in neuropathology between schizophrenia (SZ) autism spectrum disorder (ASD). Dynamic functional network connectivity (dFNC) is analysis method that explores temporal patterns (FC). We compared resting-state dFNC SZ, ASD healthy controls (HC), characterized associations symptoms, performed three-way classification based on indices.Resting-state fMRI was collected from 100 young adults: 33 ASD, 34 HC....
OBJECTIVE: The authors' goal was to evaluate the possibility of treating brain and behavioral aspects verbal memory dysfunction in patients with schizophrenia through cognitive exercises. METHOD: Eight did daily exercises that became progressively more difficult over a 10-week training period. Memory performance regional activations during task were assessed before after these RESULTS: Verbal but not nonverbal improved training; three made substantial gains, five showed little change....
Background: Verbal memory deficits have been reported in many studies of patients with schizophrenia.We evaluated the specificity these by comparing and control subjects on several verbal nonverbal auditory tests.Methods: Performance stable, medicated outpatients DSM-III-R diagnoses schizophrenia (N = 38) was compared that healthy 39) a word list immediate recall task, tone delayed discrimination tasks, serial position tasks.Before testing, were divided into 2 groups based their ability to...
We considered the hypothesis that richness of callosal interhemispheric connections has a role in determining degree behavioural laterality and time-sharing ability dual-task performance. Behavioural as measured by dichotic word listening, line bisection turning bias tests correlated inversely with midsagittal cross-sectional area corpus callosum, seen on MRI. The amount dual task interference was strongly both within-hemisphere between-hemispheres conditions. These relationships between...
Objective: To determine whether augmenting work therapy (WT) with neurocognitive enhancement (NET) yields greater improvement in working memory performance than WT alone and there is an interaction severity of impairment. Method: A total 102 participants schizophrenia or schizoaffective disorder were categorized as severely less cognitively impaired randomly assigned to receive NET + alone. consisted cognitive training exercises attention, memory, executive function, social information...
• A dichotic listening test was used to assess cerebral laterality in 26 right-handed patients with schizophrenic, schizoaffective, or primary major depressive illness and 23 controls. Clinical state assessed by twice-daily nurses' ratings patient self-ratings. Ratings of psychotic thought behavior were lower during the week highest than lowest (<i>P</i><.01). Similarly, when most improved, had higher ill Changes not specific diagnostic group, present control subjects, could be related...