A5073531380- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mental Health Treatment and Access
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Treatment of Major Depression
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Health Systems, Economic Evaluations, Quality of Life
- Fire effects on ecosystems
- Personality Disorders and Psychopathology
- Epilepsy research and treatment
- Soil erosion and sediment transport
- Autism Spectrum Disorder Research
- Cannabis and Cannabinoid Research
Yale University
2016-2025
Connecticut Mental Health Center
2016-2025
University of North Carolina at Chapel Hill
2011-2024
University of Calgary
2011-2023
University of California, San Diego
2011-2021
Zucker Hillside Hospital
2011-2021
University of California, Los Angeles
2011-2021
Stanford University
1998-2020
Columbia University
1998-2020
The University of Melbourne
2020
<h3>Context</h3> Early detection and prospective evaluation of individuals who will develop schizophrenia or other psychotic disorders are critical to efforts isolate mechanisms underlying psychosis onset the testing preventive interventions, but existing risk prediction approaches have achieved only modest predictive accuracy. <h3>Objectives</h3> To determine conversion evaluate a set algorithms maximizing positive power in clinical high-risk sample. <h3>Design, Setting, Participants</h3>...
ContextPanic disorder (PD) may be treated with drugs, psychosocial intervention, or both, but the relative and combined efficacies have not been evaluated in an unbiased fashion.ObjectiveTo evaluate whether drug therapies for PD are each more effective than placebo, one treatment is other, therapy either alone.Design SettingRandomized, double-blind, placebo-controlled clinical trial conducted 4 anxiety research clinics from May 1991 to April 1998.PatientsA total of 312 patients were included...
To address the lack of a simple and standardized instrument to assess overall panic disorder severity, authors developed scale for measurement severity.Ten independent evaluators used seven-item Panic Disorder Severity Scale 186 patients with principal DSM-III-R diagnoses (with no or mild agoraphobia) who were participating in Multicenter Collaborative Treatment Study Disorder. In addition, 89 these reevaluated same after short-term treatment. A subset 24 underwent two assessments establish...
OBJECTIVE: This study was conducted to determine the interrater reliability and predictive validity of a set diagnostic criteria for prodrome first episode schizophrenic psychosis when based on Structured Interview Prodromal Syndromes. METHOD: The subjects were patients referred evaluation because suspected schizophrenia prodromal syndrome. For study, two four raters independently diagnosed 18 basis face-to-face or videotaped interviews. 6- 12-month outcome data collected 29 patients....
Objective: This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms people with prodromal schizophrenia.Method: randomized trial occurred at four North American clinics Prevention Through Risk Identification, Management, Education project.Outpatients received (5-15 mg/day, N=31) placebo (N=29) during a 1-year double-blind treatment period no follow-up period.Efficacy measures included conversion-to-psychosis rate Scale Prodromal...
Approximately 20%-35% of individuals 12-35 years old who meet criteria for a prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores the fact that clinical high-risk cases vary considerably in risk. The authors sought create calculator, based on profiles indicators, can ascertain probability conversion individual patients.The study subjects were 596 participants from second phase North American Prodrome Longitudinal Study followed up time or last contact...
Objective: A major focus of early intervention research is determining the risk conversion to psychosis and developing optimal algorithms prediction. Although reported rates nonconversion vary in literature, rate always encompasses a majority (50%–85%) sample participants. Less known about outcome among this group, referred as false positive individuals. Method: longitudinal study was conducted more than 300 prospectively identified treatment-seeking individuals meeting criteria for...
ABSTRACT The effects of fear/anticipatory anxiety on the acoustic startle reflex were investigated in humans using a paradigm involving anticipation electric shocks. eyeblink component reflex, elicited by an abrupt auditory stimulus, was measured 9 normal volunteers during either shocks (anticipatory anxiety) or periods which no anticipated (safe period). consistently higher amplitude, and shorter latency, when subjects shocks, compared to safe periods. This effect could not be attributed...
<h3>Context</h3> Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset testing preventive interventions. <h3>Objectives</h3> To elucidate the neuropsychology CHR syndrome, to determine association neuropsychological function with conversion family history psychosis, examine whether baseline functioning predicts subsequent psychosis. <h3>Design</h3> Longitudinal...
Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These were considered psychosis by virtue of meeting research criteria derived from retrospective accounts prodrome. This study evaluated diagnostic validity prospective "prodromal syndrome" construct. Patients assessed Structured Interview Prodromal Syndromes as prodromal syndromes (n = 377) North American Prodrome Longitudinal Study compared with normal comparison (NC,...
Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that a neurodevelopmental disorder likely affects brain before onset of clinical symptoms. However, no investigation has tested whether connectivity individuals at risk for psychosis or this pattern more severe who later develop full-blown illness.To determine...
To determine the efficacy and safety of deutetrabenazine as a treatment for tardive dyskinesia (TD).One hundred seventeen patients with moderate to severe TD received or placebo in this randomized, double-blind, multicenter trial. Eligibility criteria included an Abnormal Involuntary Movement Scale (AIMS) score ≥6 assessed by blinded central video rating, stable psychiatric illness, psychoactive medication treatment. Primary endpoint was change AIMS from baseline week 12. Secondary endpoints...
Neurocognition is a central characteristic of schizophrenia and other psychotic disorders. Identifying the pattern severity neurocognitive functioning during "near-psychotic," clinical high-risk (CHR) state psychosis necessary to develop accurate risk factors for more effective potentially preventive treatments.To identify core dysfunctions associated with CHR phase, measure ability tests predict transition psychosis, determine if deficits are robust or explained by potential confounders.In...
An accurate detection of individuals at clinical high risk (CHR) for psychosis is a prerequisite effective preventive interventions. Several psychometric interviews are available, but their prognostic accuracy unknown. We conducted meta‐analysis used to examine referrals services. The index test was an established CHR instrument identify subjects with and without (CHR+ CHR−). reference onset over time in both CHR+ CHR− subjects. Data were analyzed MIDAS (STATA13). Area under the curve (AUC),...
A barrier to preventative treatments for psychosis is the absence of accurate identification persons at highest risk. blood test that could substantially increase diagnostic accuracy would enhance development prevention interventions.The North American Prodrome Longitudinal Study project a multisite endeavor aims better understand predictors and mechanisms psychosis. In this study, we measured expression plasma analytes reflecting inflammation, oxidative stress, hormones, metabolism. "greedy...