A5063201290- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Cognitive Science and Mapping
- Visual perception and processing mechanisms
- Heart Rate Variability and Autonomic Control
- Psychedelics and Drug Studies
- Spatial Cognition and Navigation
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Music Perception
- Quantum Mechanics and Applications
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Cognitive Functions and Memory
- Visual and Cognitive Learning Processes
- Neuroscience, Education and Cognitive Function
University of Ljubljana
2015-2024
Yale University
2023
University of Zagreb
2020-2021
Klinika za psihijatriju Vrapče
2013-2019
Institut za filozofiju
2013
Washington University in St. Louis
2006-2012
Medical University of Vienna
2010
Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify mechanism--global connectivity--by which components this might coordinate other networks. A lateral prefrontal cortex (LPFC) region's activity was found predict performance in high demand working memory task also exhibit global connectivity. Critically, connectivity LPFC region, involving connections both...
Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding its relationship to symptoms and diagnoses shared clinical presentation, such as bipolar illness, which exist on spectrum. Using resting-state functional magnetic resonance imaging, we characterized 90 patients versus matched controls via:...
Significance This study identified elevated global brain signal variability in schizophrenia, but not bipolar illness. was related to schizophrenia symptoms. A commonly used analytic procedure neuroimaging, regression, attenuated clinical effects and altered inferences. Furthermore, local voxel-wise variance increased independent of regression. Finally, neurobiologically grounded computational modeling suggests a putative mechanism, whereby overall connection strength may underlie observed...
Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that a neurodevelopmental disorder likely affects brain before onset of clinical symptoms. However, no investigation has tested whether connectivity individuals at risk for psychosis or this pattern more severe who later develop full-blown illness.To determine...
Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-HT) and dopamine receptors. Despite the therapeutic scientific interest in LSD, specific receptor contributions to its neurobiological effects remain unknown. Methods: We therefore conducted a double-blind, randomized, counterbalanced, cross-over studyduring which 24 healthy human participants received either (i) placebo+placebo, (ii) placebo+LSD (100 µg po), or (iii) Ketanserin, selective 5-HT2A...
Glutamatergic neurotransmission mediated by N -methyl- d -aspartate (NMDA) receptors is vital for the cortical computations underlying cognition and might be disrupted in severe neuropsychiatric illnesses such as schizophrenia. Studies on this topic have been limited to processes local circuits; however, involves large-scale brain systems with multiple interacting regions. A prominent feature of human brain’s global architecture anticorrelation default-mode vs. task-positive systems. Here,...
Strong evidence implicates prefrontal cortex (PFC) as a major source of functional impairment in severe mental illness such schizophrenia. Numerous schizophrenia studies report deficits PFC structure, activation, and connectivity patients with chronic illness, suggesting that deficient occurs this disorder. However, the patterns during onset its longitudinal progression remain uncharacterized. Emerging suggests early-course involves increased glutamate, which might elevate connectivity. To...
Significance Schizophrenia is linked to widespread neuronal-level changes causing cortical excitation-inhibition imbalance. However, functional neuroimaging reveals preferential association network dysconnectivity. Therefore, a tension exists between two competing frameworks: global versus localized neural dysfunction in schizophrenia. To link these levels of analysis, this study initially simulated cellular-level glutamatergic deficits, generating network-level predictions results revealed...
A growing number of studies have reported altered functional connectivity in schizophrenia during putatively "task-free" states and the performance cognitive tasks. However, there been few systematic examinations across rest different task to assess degree which reflects a stable characteristic or whether changes vary as function demands. We assessed three working memory loads an N-back (0-back, 1-back, 2-back) among: (1) individuals with (N = 19); (2) siblings 28); (3) healthy controls 10);...
Empirical and theoretical studies implicate thalamocortical circuits in schizophrenia, supported by emerging resting-state functional connectivity (rs-fcMRI). Similar but attenuated alterations were found bipolar disorder (BD). However, it remains unknown if segregated loops within systems show distinct rs-fcMRI schizophrenia. For instance, the mediodorsal (MD) nucleus, known to project prefrontal networks, may be differently altered than lateral geniculate nucleus (LGN), occipital cortex....