A5070306053- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Suicide and Self-Harm Studies
- Hemoglobinopathies and Related Disorders
- Stress Responses and Cortisol
- Prenatal Screening and Diagnostics
- COVID-19 and Mental Health
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Blood groups and transfusion
- Sleep and related disorders
- Genomics and Phylogenetic Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Iron Metabolism and Disorders
- Genomics and Rare Diseases
- Regulation of Appetite and Obesity
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
First Hospital of China Medical University
2016-2025
China Medical University
2016-2025
Macau University of Science and Technology
2024
Guangxi Maternal and Child Health Hospital
2014-2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2024
Northeastern University
2024
Sheng Jing Hospital
2023
Guangxi Center for Disease Prevention and Control
2021
BGI Group (China)
2014-2015
Recent advances in whole-genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy ability describe context (haplotypes) which genome variants co-occur a cost-effective manner. Here we low-cost DNA haplotyping process, long fragment read (LFR) technology, is similar single molecules without cloning or separation metaphase chromosomes. In this study, ten LFR libraries were made using only ∼100...
Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers elucidate the molecular mechanisms underlying these adaptations. We discover an expansion innate immune system genes in may provide defence against terrestrial pathogens. Several ammonia excretion pathway gills experienced positive selection, suggesting important roles mudskippers'...
Abstract There are limited resting‐state functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD). Of these studies, connectivity analyses mostly used. However, a new method based on the magnitude of low frequency fluctuation (LFF) during fMRI may provide important insight into MDD. In this study, we examined amplitude LFF (ALFF) within whole brain 30 treatment‐naïve MDD subjects and healthy control (HC) subjects. When compared with HC, showed increased ALFF...
<sec><title>Background</title> Little empirical evidence is known about the sleep quality of frontline health professionals working in isolation units or hospitals during novel coronavirus disease (COVID-19) outbreak China. This study thus aimed to examine prevalence poor and its demographic correlates among professionals. </sec><sec><title>Methods</title> a multicenter, cross-sectional survey conducted Liaoning province, Sleep was measured by Pittsburgh Quality Index (PSQI)....
Background: Schizophrenia (SZ), bipolar disorder (BD), and major depressive (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical biological features these disorders. No previous studies have examined brain structural concurrently 3 The aim of this study was to identify the extent alterations SZ, BD, MDD. We gray matter (GM) volume white (WM) integrity a total 485 individuals (135 with 86 108 MDD, 156 healthy controls...
Several lines of evidence support the involvement transcriptomic and epigenetic mechanisms in brain structural deficits major depressive disorder (MDD) separately. However, research these two areas has remained isolated. In this study, we proposed an integrative strategy that combined neuroimaging, brain-wide gene expression, peripheral DNA methylation data to investigate genetic basis gray matter abnormalities MDD. The MRI T1-weighted images Illumina 850 K microarrays were obtained from 269...
<h3>Background:</h3> Convergent evidence suggests dysfunction within the prefrontal cortex (PFC) and amygdala, important components of a neural system that subserves emotional processing, in individuals with major depressive disorder (MDD). Abnormalities this left hemisphere during processing negative stimuli are especially implicated. In study, we used functional magnetic resonance imaging (fMRI) to investigate amygdala–PFC connectivity face medication-naive MDD. <h3>Methods:</h3>...
Background Convergent studies suggest that morphological abnormalities of frontal-subcortical circuits which involved with emotional and cognitive processing may contribute to the pathophysiology major depressive disorder (MDD). Antidepressant treatment has been reported reverse functional in MDD have treating effects related brain abnormalities. In this study, we used voxel-based morphometry method investigate whole structural single episode, medication-naïve patients. Furthermore,...
Alterations in circuits involving the amygdala have been repeatedly implicated schizophrenia neuropathology, given their role stress, affective salience processing, and psychosis onset. Disturbances whole-brain functional connectivity associated with yet to be fully characterized despite importance psychosis. Moreover, it remains unknown if there are alterations across illness phases. To evaluate this possibility, we compared healthy comparison subjects (HCS), individuals at high risk (HR)...
A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, neural system effects of rs35936514 that mediate are unknown. The present work explores whether moderates brain regional activity MDD. total 160 subjects were studied: a CC group homozygous for C allele (23 individuals MDD and 57 controls) T-carrier carrying high risk T (CT/TT genotypes; 22 58 controls). All...
Background: Cognitive dysfunction is considered a core feature among schizophrenia (SZ), bipolar disorder (BD), and major depressive (MDD). Despite copious literature on comparisons of cognitive in these disorders, the relationship between symptom dimensions remains unclear. The study aims to examine impairment psychopathology SZ, BD, MDD. Methods: A total 716 participants (262 patients with 104 101 MDD, 249 healthy controls) were assessed using MATRICS Consensus Battery (MCCB), Wisconsin...
Cognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas the brain exist SZ patients. The relationships between these two indexes largely unexplored SZ. MATRICS Consensus Battery (MCCB) was used to measure cognitive impairment multi-dimensional fields This study conducted explore relationship and amplitude low-frequency fluctuation (ALFF) A total 104 participants (44 patients 60 age- gender-matched healthy controls...
Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well the amygdala form a circuit implicated emotion regulation pathogenesis MDD. aim this study was to identify whether patients with MDD who had history SA show structural functional connectivity abnormalities PFC relative without SA. We measured gray matter volume amygdala-PFC using magnetic resonance imaging...
Vortioxetine hydrobromide is a common clinical medication for major depressive disorder (MDD). However, it remains unclear whether vortioxetine acts by affecting the structure and composition of gut microbiota. Here, we analyzed fecal samples from 28 healthy controls (HCs) 26 patients with MDD before treatment hydrobromide, at 4 weeks after treatment, 8 treatment. High-throughput pyrosequencing showed that, according to Chao1 Shannon indices, bacterial α-diversity was higher in than HCs ( p...
Abstract Nearly a quarter of bipolar disorder (BD) patients were misdiagnosed as major depressive (MDD) patients, which cannot be corrected until mania/hypomania develops. It is important to recognize these obstacles so that the appropriate treatment can initiated. Thus, we sought distinguish with BD from MDD, especially identify before mania/hypomania, and further explore potential trait features allow accurate differential diagnosis independent state matters. Functional magnetic resonance...
Currently, the methods available for preimplantation genetic diagnosis (PGD) of in vitro fertilized (IVF) embryos do not detect de novo single-nucleotide and short indel mutations, which have been shown to cause a large fraction diseases. Detection all these types mutations requires whole-genome sequencing (WGS). In this study, advanced massively parallel WGS was performed on three 5- 10-cell biopsies from two blastocyst-stage embryos. Both parents paternal grandparents were also analyzed...