A5040631542- Healthcare Operations and Scheduling Optimization
- Healthcare Policy and Management
- Acute Ischemic Stroke Management
- Emergency and Acute Care Studies
- Advanced biosensing and bioanalysis techniques
- Simulation Techniques and Applications
- Patient-Provider Communication in Healthcare
- Genomics and Phylogenetic Studies
- Health Systems, Economic Evaluations, Quality of Life
- Reinforcement Learning in Robotics
- Gene expression and cancer classification
- Statistical Methods and Bayesian Inference
- Cerebrovascular and Carotid Artery Diseases
- Statistical Methods and Inference
- Complex Systems and Decision Making
- Artificial Intelligence in Games
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Radiology practices and education
- Sports Analytics and Performance
- Patient Satisfaction in Healthcare
- Clinical Reasoning and Diagnostic Skills
- Hospital Admissions and Outcomes
- Global Cancer Incidence and Screening
- Palliative Care and End-of-Life Issues
Norwegian Computing Center
2022-2025
Akershus University Hospital
2014-2023
University of Oslo
2004-2020
Oslo University Hospital
2016-2020
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Complete Genomics (United States)
2009-2012
Ariadne Diagnostics (United States)
2012
10X Genomics (Sweden)
2012
Uppsala University
2003-2007
Toward $1000 Genomes The ability to generate human genome sequence data that is complete, accurate, and inexpensive a necessary prerequisite perform genome-wide disease association studies. Drmanac et al. (p. 78 , published online 5 November) present technique advancing toward this goal. method uses Type IIS endonucleases incorporate short oligonucleotides within set of randomly sheared circularized DNA. DNA polymerase then generates concatenated copies the circular leading formation compact...
Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, relationship between obesity and OA hand(s) hip(s) remains controversial needs further investigation. The purpose this study was to investigate impact on incident hip, knee, hand a general population followed 10 years.A total 1854 people aged 24-76 years 1994 participated Norwegian musculoskeletal pain both 2004. Participants with or rheumatoid arthritis those above 74 were excluded, leaving n =...
Perforated colonic diverticulitis usually requires surgical resection, which is associated with significant morbidity. Cohort studies have suggested that laparoscopic lavage may treat perforated less morbidity than resection procedures.To compare the outcomes from those for colon diverticulitis.Multicenter, randomized clinical superiority trial recruiting participants 21 centers in Sweden and Norway February 2010 to June 2014. The last patient follow-up was December 2014 final review...
Recent advances in whole-genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy ability describe context (haplotypes) which genome variants co-occur a cost-effective manner. Here we low-cost DNA haplotyping process, long fragment read (LFR) technology, is similar single molecules without cloning or separation metaphase chromosomes. In this study, ten LFR libraries were made using only ∼100...
Abstract Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) 5 regions (DMRs), which study detail using whole genome bisulphite sequencing. We replicate the top DMP ( RPS6KA2 ) DMRs VMP1, ITGB2 TXK an independent cohort. Using paired genetic epigenetic...
We present a tightly controlled process for strand-specific amplification of circularized DNA molecules. Tandem repeated complements circles are generated by rolling-circle replication, and converted to monomer opposite polarity that the starting material. These then subjected one more round replication circularization, can be further repeated. The method directed produce single-stranded circular or linear monomers, concatemers desired polarity. reaction is not product inhibited, yield...
We have developed a procedure for massively parallel resequencing of multiple human genes by combining highly multiplexed and target-specific amplification process with high-throughput sequencing technology. The is based on oligonucleotide constructs, called selectors, that guide the circularization specific DNA target regions. Subsequently, circularized sequences are amplified in multiplex analyzed using sequencing-by-synthesis As proof-of-concept study, we demonstrate 10 cancer covering...
Background: Early identification of patients with a prolonged stay due to acute exacerbation chronic obstructive pulmonary disease (COPD) may reduce risk adverse event and treatment costs. This study aimed identify predictors after COPD based on variables admission; the also looked establish prediction model for length (LOS). Methods: We extracted demographic clinical data from medical records 599 discharged an between March 2006 December 2008 at Oslo University Hospital, Aker. used logistic...
Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in colitis, using a comprehensive set of proteins.We obtained plasma samples biobanked from individuals who developed later life (n = 72) and matched healthy controls 140) within population-based screening cohort. measured 92 proteins related proximity extension assay. The biologic relevance these findings was validated an inception cohort patients with 101) 50). To examine...
We present a method to specifically select large sets of DNA sequences for parallel amplification by PCR using target-specific oligonucleotide constructs, so-called selectors. The selectors are duplexes with single-stranded target-complementary end-sequences that linked general sequence motif. In the selection process, pool is combined denatured restriction digested DNA. Each selector hybridizes its respective target, forming individual circular complexes covalently closed enzymatic...
AbstractThis article addresses issues of model criticism and comparison in Bayesian contexts, focuses on the use so-called posterior predictive p values (ppp). These involve a general discrepancy or conflict measure depend prior, model, data. They are used statistical practice to quantify degree surprise data compare different combinations prior model. The distribution such ppp is far from uniform however, as we demonstrate for models, making their interpretation difficult matter. We propose...
Abstract Background Recent randomized trials demonstrated that laparoscopic lavage compared with resection for Hinchey III perforated diverticulitis was associated similar mortality, less stoma formation but a higher rate of early reintervention. The aim this study to compare 1-year outcomes in patients who participated the Scandinavian Diverticulitis (SCANDIV) trial. Methods Between February 2010 and June 2014, from 21 hospitals Norway Sweden presenting suspected were enrolled multicentre...
Hip fracture patients are frail and have a high mortality. We investigated whether the introduction of fast track care reduced 30-day mortality after hip fractures. Fast was established at our institution in October 2013. Data from Norwegian Fracture Register electronic hospital records were merged for 2230 operated department January 2012 through December 2015. 1090 these before (conventional treatment group) 1140 (fast group). analysed by univariate analysis binary logistic regression....
Abstract Aim To assess the pathobiological and translational importance of whole-blood transcriptomic analysis in inflammatory bowel disease [IBD]. Methods We analysed expression profiles from paired-end sequencing a discovery cohort 590 Europeans recruited across six countries IBD Character initiative (newly diagnosed patients with Crohn’s [CD; n = 156], ulcerative colitis [UC; 167], controls [n 267]), exploring differential [DESeq2], co-expression networks [WGCNA], transcription factor...
Abstract Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using Illumina 450k platform a case-control study an inception cohort (295 controls, 154 Crohn’s [CD], 161 ulcerative colitis [UC], 28 IBD unclassified [IBD-U)] with covariates age, sex and cell counts, deconvoluted by Houseman method. Genotyping performed...
Background and purpose - Surgical site infection (SSI) is a devastating complication of hip fracture surgery. We studied the contribution early deep SSI to mortality after surgery risk factors for with emphasis on duration surgery.Patients methods 1,709 patients (884 hemi-arthroplasties, 825 sliding screws), operated from 2012 2015 at single center were included. Data obtained Norwegian Hip Fracture Register, electronic hospital records, Surveillance System Antibiotic Use Hospital-Acquired...
Abstract Aims Studies with implantable cardiac monitors (ICMs) show that one-third of patients cryptogenic stroke/transient ischaemic attack (TIA) have episodes subclinical atrial fibrillation (SCAF) and benefit switching from antiplatelet- to anticoagulant therapy. However, ICMs are costly resource demanding. We aimed build a score based on participant’s baseline characteristics could assess individual risk SCAF. Methods results In prospective study, 236 eligible final diagnosis stroke/TIA...
“Just Accepted” papers have undergone full peer review and been accepted for publication in Radiology: Artificial Intelligence. This article will undergo copyediting, layout, proof before it is published its final version. Please note that during production of the copyedited article, errors may be discovered which could affect content. Purpose To evaluate cancer detection marker placement accuracy two artificial intelligence (AI) models developed interpretation screening mammograms....