Erik Andersson
A5101534405- Inflammatory Bowel Disease
- Microscopic Colitis
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Rheumatoid Arthritis Research and Therapies
- Celiac Disease Research and Management
- Otitis Media and Relapsing Polychondritis
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
Örebro University
2017-2024
Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in colitis, using a comprehensive set of proteins.We obtained plasma samples biobanked from individuals who developed later life (n = 72) and matched healthy controls 140) within population-based screening cohort. measured 92 proteins related proximity extension assay. The biologic relevance these findings was validated an inception cohort patients with 101) 50). To examine...
Objective Genetic and immunological data indicate that inflammatory bowel disease (IBD) are characterized by specific protein profiles. However, the serum proteome of IBD is still to be defined. We aimed characterize profiles Crohn's (CD) ulcerative colitis (UC), using novel proximity extension assay. Methods A panel 91 proteins were quantified in a discovery cohort CD (n = 54), UC patients healthy controls (HCs; n 54). performed univariate analyses t-test, with false rate correction. sparse...
Abstract Active microbes likely have larger impact on gut health status compared to inactive or dormant microbes. We investigate the composition of active and total mucosal microbiota treatment-naïve ulcerative colitis (UC) patients determine microbial picture at start-up phase disease, using both a 16S rRNA transcript gene amplicon sequencing. DNA RNA were isolated from same colonic biopsies. Our aim was identify members in early stages disease reveal which are present, but do not act as...
Abstract Background Recent genetic and transcriptomic data highlight the need for improved molecular characterisation of inflammatory bowel disease (IBD). Proteomics may advance delineation IBD phenotypes since it accounts post-transcriptional modifications. Aim We aimed to assess spectrum based on serum proteins identify discriminative patterns underlying biological subtypes across multiple European cohorts. Methods Using proximity extension methodology, we measured 86 inflammation-related...