Mauro DʼAmato
A5071883882- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Digestive system and related health
- Neuropeptides and Animal Physiology
- Gut microbiota and health
- Microscopic Colitis
- Diet and metabolism studies
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Genetic factors in colorectal cancer
- Congenital gastrointestinal and neural anomalies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Gastroesophageal reflux and treatments
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Colorectal Cancer Screening and Detection
- Diabetes and associated disorders
- Allergic Rhinitis and Sensitization
- Hypothalamic control of reproductive hormones
Karolinska Institutet
2015-2025
Ikerbasque
2016-2025
CIC bioGUNE
2021-2025
Libera Università Maria SS. Assunta
2022-2024
Monash University
2019-2023
Biogipuzkoa Health Research Institute
2016-2021
BioCruces Health research Institute
2015-2021
University of the Basque Country
2017-2021
Euskadiko Parke Teknologikoa
2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2020
: Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or drug-to-disease relationships, merging several information levels. However, noisy nature and scarcity genomic data many diseases are important limitations to such approaches. Here we focused a drug-centered approach by predicting therapeutic class FDA-approved compounds, not considering concerning diseases. We propose novel predict based state-of-the-art...
Abstract Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) 5 regions (DMRs), which study detail using whole genome bisulphite sequencing. We replicate the top DMP ( RPS6KA2 ) DMRs VMP1, ITGB2 TXK an independent cohort. Using paired genetic epigenetic...
Abstract GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that perturbed these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and 23,650 cis -eQTL. We show determined ∼9720 modules, which ∼3000 operate in multiple tissues ∼970 on genes. modules drive association 63 200 loci, enriched multigenic...
Abstract Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost endoscopic appearance of the colon, watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three subtypes, collagenous colitis, lymphocytic incomplete microscopic colitis. With ongoing uncertainties new developments in clinical management there need for evidence‐based guidelines to improve medical care patients suffering from this disorder. Methods...
The cytokine pattern secreted by T cells on viral antigen recognition is believed to exert a profound influence both the type of disease caused infecting agent and final outcome infection. To characterize associated with spontaneous resolution acute hepatitis B, we analyzed interferon gamma (IFN-γ), interleukin (IL)-4, IL-5 production wide series B virus (HBV) nucleocapsid-specific T-cell lines (34 lines) clones (71 clones) derived from peripheral blood 13 patients during or recovery phase...
Abstract Ankylosing spondylitis (AS) is an autoimmune disorder strongly associated with HLA‐B27. A direct role of B27 molecules in the disease pathogenesis has been postulated, possibly by presenting to T cells as‐yet unidentified arthritogenic peptide that triggers response. There are nine HLA‐B27 alleles differing from each other at one or more amino acid positions. It important, for identification peptide, define which alleles, and therefore polymorphic positions, predispose disease....
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries already had a tremendous impact on our understanding of the genetic architecture directed functional revealed some biological functions are important to IBD (e.g. autophagy). Nonetheless, can only explain small proportion variance...
Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in process, forming complex interaction with host immune system, hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition 1135 individuals from population-based cohort. overall females males was significantly different (p = 0.001), showing...
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) rare genetic form disaccharide malabsorption characterised by diarrhoea, abdominal pain bloating, which features IBS. We tested (SI) gene variants for their potential relevance in IBS.We sequenced SI exons seven familial cases, screened four CSID mutations (p.Val557Gly, p.Gly1073Asp, p.Arg1124Ter p.Phe1745Cys)...