Fabian Frost
A5089391172- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Digestive system and related health
- Cystic Fibrosis Research Advances
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Food Security and Health in Diverse Populations
- Peptidase Inhibition and Analysis
- Gastroesophageal reflux and treatments
- Pain Management and Placebo Effect
- Occupational and environmental lung diseases
- Genomics and Phylogenetic Studies
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
Universitätsmedizin Greifswald
2018-2025
Universität Greifswald
2020
Children's Health Ireland at Crumlin
2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
Hôpital Pierre Wertheimer
2010
University of Copenhagen
1980-1981
Rigshospitalet
1978-1981
Glostrup Hospital
1978
... The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-START (recruited between 1997 and 2001) SHIP-TREND 2008 to 2012), which were established examine health disease status general adult population Northeast Germany given that this region had lowest life expectancy 1990s.1 initial cohort was renamed avoid confusion with designation SHIP, as whole project different cohorts. Both serve purpose understanding concepts their greatest possible complexity, rather...
In acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease late death. Understanding how immunological host defence mechanisms fail to protect intestinal barrier is great importance in reducing mortality disease. Here, we studied role Treg/Th17 balance maintaining function a mouse model AP.AP was induced by partial duct ligation C57Bl/6 or DEREG mice, which regulatory T-cells (Treg) were depleted...
Molecular profiling techniques such as metagenomics, metatranscriptomics or metabolomics offer important insights into the functional diversity of microbiome. In contrast, 16S rRNA gene sequencing, a widespread and cost-effective technique to measure microbial diversity, only allows for indirect estimation function. To mitigate this, tools PICRUSt2, Tax4Fun2, PanFP MetGEM infer profiles from sequencing data using different algorithms. Prior studies have cast doubts on quality these...
The intestinal microbiome affects the prevalence and pathophysiology of a variety diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity was often observed in association with poorer health outcomes disease general. Conversely, factors manifest that determine long-term stability instability are largely unknown. We aimed identify disease-relevant phenotypes associated faecal microbiota (in-)stability.A total 2564 paired samples 1282 participants...
The global obesity epidemic constitutes a major cause of morbidity and mortality challenging public health care systems worldwide. Thus, better understanding its pathophysiology the development novel therapeutic options are urgently needed. Recently, alterations intestinal microbiome in obese have been discussed as promoting factor contributing to related diseases such type 2 diabetes metabolic syndrome. present pilot study investigated effect structured weight loss program on fecal...
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
Glaucoma is an eye disease that the most common cause of irreversible blindness worldwide. It has been suggested gut microbiota can produce reactive oxygen species and pro-inflammatory cytokines may travel from gastric mucosa to distal sites, for example, optic nerve head or trabecular meshwork. There evidence a gut-eye axis, as microbial dysbiosis associated with retinal diseases. We investigated composition in patients glaucoma healthy controls. Moreover, we analyzed association microbiome...
INTRODUCTION: Exocrine pancreatic function is a critical host factor in determining the intestinal microbiota composition. Diseases affecting exocrine pancreas could therefore influence gut microbiome. We investigated changes of patients with chronic pancreatitis (CP). METHODS: Patients clinical and imaging evidence CP (n = 51) were prospectively recruited compared twice number nonpancreatic disease controls matched for distribution age, sex, body mass index, smoking, diabetes mellitus,...
Abstract Helicobacter (H.) pylori is the most important cause for peptic ulcer disease and a risk factor gastric carcinoma. How colonization with H. affects intestinal microbiota composition in humans unknown. We investigated association of infection population-based cohort Study-of-Health-in-Pomerania (SHIP)-TREND. Anti- serology stool antigen tests were used to determine status. The fecal 212 positive subjects matched negative control individuals was assessed using 16S rRNA gene...
Objective Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor Severity; P-MAPS) early at hospital admission. Design Buccal and rectal microbial swabs were collected from 424 patients with within 72 hours admission 15 European centres. All samples sequenced by full-length 16S rRNA metagenomic sequencing using Oxford Nanopore Technologies. Primary endpoint was...
The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which subsequently oxidized TMAO in the liver, formed by intestinal bacteria via distinct biochemical routes from dietary precursors that are enriched animal product-based foods. To get a full picture of entire process diet > microbiota axis, we quantified potential TMA-forming and plasma metabolites using gene-targeted assays targeted...
Abstract To study the effect of host genetics on gut microbiome composition, MiBioGen consortium curated and analyzed genome-wide genotypes 16S fecal data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 out 410 genera were detected in more than 95% samples. A association (GWAS) genetic variation relation to microbial taxa identified 31 loci affecting at a significant (P<5×10 −8 ) threshold. One locus, lactase ( LCT gene reached...
Abstract Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor morbidity health care expenditure. Intestinal microbiota have variously been implicated as either contributing gallstone formation or be affected by cholecystectomy. We conducted large-scale investigation on 404 carriers, 580 individuals post-cholecystectomy 984 healthy controls with similar distributions age, sex, body mass index, smoking habits,...
Abstract Purpose Exocrine pancreatic function is critically involved in regulating the gut microbiota composition. At same time, its impairment acutely affects human metabolism. How these 2 roles are connected unknown. We studied how exocrine pancreas contributes to metabolism via modulation of microbiota. Design Fecal samples were collected 2226 participants population-based Study Health Pomerania (SHIP/SHIP-TREND) determine (pancreatic elastase enzyme-linked immunosorbent assay) and...
Abstract Malnutrition is a common complication of chronic pancreatitis (CP) and liver cirrhosis (LC). Inadequate food intake considered relevant driver malnutrition in both entities. However, the contribution habitual diet to impaired nutritional status unclear. In prospective, multicenter cross-sectional study, we recruited patients with confirmed CP or LC healthy volunteers as control group. was diagnosed according Global Leadership Initiative on criteria. We comprehensively investigated...
Abstract Sedentarism is characterized by low levels of physical activity, a risk factor for obesity and cardio-metabolic diseases. It can also adversely affect the composition diversity gut microbiome which may result in harmful consequences human health. While cardiorespiratory fitness (CRF) inversely independently associated with cardiovascular factors diseases all-cause mortality, relationship between CRF not well known. A total 3,616 individuals from two independent population-based...
Background: Lumen apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is considered a significant clinical problem and identification of risk factors for could contribute novel preventive strategies. A previous study suggested contradictory effects proton pump inhibitor (PPI) intake on the necrosectomy rate. Methods: We conducted European-wide multicenter retrospective cohort assessing WONs drained by LAMS. Primary aims were assess strength an...
Patients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We investigated the factors, phenotypic presentation, health implications associated malnutrition in CP.In multicenter cross-sectional study we recruited patients confirmed CP healthy volunteers as control group. Malnutrition was diagnosed according criteria proposed by Global Leadership Initiative on Malnutrition. performed detailed examinations...