A5013401018- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Diversity and Career in Medicine
- Esophageal and GI Pathology
- Diabetes Management and Research
- Cancer Diagnosis and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Global Health Workforce Issues
- Frailty in Older Adults
- Health and Medical Research Impacts
- Colorectal Cancer Screening and Detection
- Diabetes and associated disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Medical Education and Admissions
- Pregnancy-related medical research
- Intestinal and Peritoneal Adhesions
- Head and Neck Cancer Studies
Royal Bournemouth Hospital
2023-2024
University of Sheffield
2021-2024
Royal Hallamshire Hospital
2018-2023
Southampton General Hospital
2023
Sheffield Teaching Hospitals NHS Foundation Trust
2018-2023
Northern General Hospital
2023
Chapel Allerton Hospital
2021
Leeds Teaching Hospitals NHS Trust
2021
Rotherham General Hospital
2021
Hospital Universitario Puerta del Mar
2021
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
Abstract Background Parameters to adapt individual treatment strategies for patients with pancreatic ductal adenocarcinoma (PDAC) are urgently needed. The present study aimed evaluate body composition parameters as predictors of overall survival (OS) in PDAC patients. Methods Measurements were performed on computed tomography scans at diagnosis. Height‐standardized and Body Mass Index‐ sex‐adjusted regression formulas deriving cut‐offs from a healthy population used. Kaplan‐Meier method the...
Background: We have used the Amplatzer ductal occluder for transcatheter closure of large persistently patent arterial ducts, and our experience to assess safety efficacy device in young children infants. Methods patients: prospectively 43 patients with reviewing identify any problems or complications. Results: The procedure proved successful 42 patients. achieved complete occlusion duct 33 (78.5 per cent) on day insertion. In 6 additional patients, occurred 1 week months after procedure....
Pancreatic exocrine insufficiency (PEI) is an under-diagnosed condition. Untreated PEI can result in developing gastrointestinal symptoms and long-term complications including weight loss, nutrient deficiencies, sarcopenia osteoporosis. Current best practice recommends testing for certain disorders chronic pancreatitis, cystic fibrosis, pancreatic cancer post-pancreatic surgery. However, there increasing evidence that associated with a number of conditions addition to the aforementioned...
Purpose Clinical trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn’s disease (CD). Further real-world data is needed to inform clinical practice. The primary outcome was assess corticosteroid-free remission after initiation. Secondary outcomes included effect on activity scores, biochemical markers, concomitant drug use, endoscopic remission, surgical intervention, hospital admissions adverse events.Materials methods A multi-centre retrospective...
To assess the risks and benefits of reverse mentoring consultants by junior doctors.A feasibility study divided into two phases: first a semistructured interview where performance participating was assessed doctors then second phase allowing for feedback to be given on one-to-one basis. Data collected through questionnaires with free text questions Likert scores.Tertiary teaching hospital in UK.Six (66.6% male, age range 31-40 years) five (80% 35-65 years 5-20 years).Reverse session.The...
Abstract Purpose The presence of a sarcopenia adversely affects the prognosis patients with pancreatic cancer. There is an emerging role for using computed tomography (CT) to calculate skeletal muscle index (SMI) and sarcopenia. aim this study was assess if detecting ‘computed tomographic sarcopenia’ feasible can contribute management locally advanced cancer (LAPC). Methods Patients diagnosed LAPC referred endoscopic ultrasound-guided biopsy (EUS-B) by our regional network were identified....
There are few studies assessed the efficacy and mortality of endoscopic retrograde cholangiopancreatography (ERCP) for removal common bile duct (CBD) stones in elderly aged ≥90 years. We aimed to assess safety CBD nonagenarians.We retrospectively reviewed ERCP reports stone removal. The therapeutic outcomes were collected. length stay (LOS), total number adverse events, rate compared between groups.A 125 nonagenarians with 1,370 controls (65-89 years old individuals). mean LOS was...
<h3>Abstract</h3> There is cumulative evidence that pancreatic exocrine insufficiency (PEI) under-recognised and can occur in patients with 'at-risk' conditions. Thus, we aimed to assess the current practice yield of requesting faecal elastase (FEL-1), an indicator PEI, We prospectively recruited attending secondary care clinics diabetes mellitus (DM), people living HIV (PLHIV) inpatients admitted hospital high alcohol intake (HAI). All underwent testing FEL-1. Those PEI (FEL-1 <200 μg/g)...
Pancreatic exocrine insufficiency (PEI) can be difficult to diagnose and causes maldigestion symptoms malabsorption. There has been a number of studies that have identified PEI associated micronutrient deficiencies (PEI-MD), however there is variation in both the frequency type PEI-MD reported, with majority including patients due chronic pancreatitis (CP) or CP without PEI. paucity information regarding prevalence yield testing for clinical setting suspected benign pancreatic diseases.To...
Objective Most studies have assessed the impact of elevated serum amylase levels in clinical practice, but only a few investigated significance low amylase. We therefore, aimed to review literature understand conditions associated with and its relevance. Method This systematic was performed accordance criteria established Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines. The search conducted on Medline Embase databases until November 2022. After identifying relevant...
<h3>Background</h3> The BSG offers a mentorship programme aimed at those in transitional phases of their career and less experienced consultants. Reverse mentoring, the act junior persons mentoring seniors, has gained traction non-healthcare settings as means closing gap between Boomers Millennials. There is no data on applying this to medical workforce. We present first real clinical experience. <h3>Methods</h3> A mixed-methods feasibility study practicalities reverse complete two phases....
<b><i>Background:</i></b> Pancreatic exocrine insufficiency (PEI) and subsequent malnutrition can be difficult to diagnose but lead sarcopenia increased mortality morbidity even in benign disease. Digital skeletal muscle analysis has been increasingly recognised as a tool sarcopenia. <b><i>Objective:</i></b> The aim of the study was assess prevalence patients with PEI secondary disease using novel recognition software....
<h3>Introduction</h3> Pancreatic adenocarcinoma (PDAC) has a very poor prognosis with most patients presenting advanced incurable disease. Palliative chemotherapy can have significant improvement in survival, but given the potential severe complications patient assessment and histological confirmation endoscopic ultrasound fine needle aspiration (EUS-FNA) is required. The rapid progression of PDAC result urgently travelling to tertiary centres undergoing EUS-FNA (which an invasive, sedated...
<h3>Introduction</h3> National standards recommend the accuracy of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) pancreatic solid lesions should exceed 78%. Presence self-expanding metal stents (SEMS) placed to relieve biliary obstruction can potentially lower this by causing acoustic shadowing and localised inflammation complicating imaging histological interpretation. Fine biopsy (FNB) needles have been developed obtain cores tissue in an attempt improve accuracy. We...
Abstract Background It is estimated that one in four persons the UK will be &gt; 65 years old by 2050. Endoscopic retrograde cholangiopancreatography (ERCP) recommended therapy for removals of common bile duct (CBD) stones. There a lack data on outcome ERCP very elderly. We aimed to investigate safety and efficacy management CBD stones elderly &gt;90 compared with those aged 65-89 old. Methods retrospectively analysed patients undergone between 2016-2020. Those conditions other than...
The incidental discovery of pancreatic cysts in asymptomatic patients is on the rise due to widespread use cross-sectional imaging. challenge management distinguishing those with malignant potentials, like mucinous cysts, from non-mucinous that have negligible potentials. Similarly, it can be difficult identify harbour high-grade dysplasia or early cancer. This review focuses recent advances detecting cancer and premalignant potential.
<h3>Background</h3> Amylase is a pancreatic exocrine enzyme which has also been shown to be implicated in an exocrine-endocrine axis. Thus, number of conditions may affect this axis and amylase activity. We aimed review the literature understand associated with low impact clinical practice <h3>Methods</h3> This systematic was performed accordance criteria established Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. The search conducted on Medline Embase...
<h3>Introduction</h3> Oesophagogastroduodenoscopy (OGD) is the accepted gold standard investigation for upper GI symptoms although quality has rarely been assessed. In this study, of OGD and effects sedation, procedural tolerance duration examination were investigated. <h3>Methods</h3> Consecutive out-patients undergoing recruited. Patients scored (none-severe: 0–10) distress, abdominal discomfort (AD) pain (AP). Video recordings OGDs reviewed, scoring views (score 1–5:<25%, 25%–50%,...
<h3>Introduction</h3> The BSG and AUGIS quality standards in upper gastrointestinal endoscopy recommend taking biopsies for histological examination to diagnose inflammatory, pre- or malignant lesions which may not be visible the naked eye [Beg, Gut 2018]. This increase duration cost of procedure potentially reduce focus on mucosal inspection. study aimed investigate diagnostic value (changes diagnosis contribution management) added by histology its cost. <h3>Methods</h3> Patients undergoing...