A5062110679- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Homelessness and Social Issues
- Health disparities and outcomes
- Food Security and Health in Diverse Populations
- Pneumocystis jirovecii pneumonia detection and treatment
- Urban, Neighborhood, and Segregation Studies
- Chemical Synthesis and Reactions
- Esophageal Cancer Research and Treatment
- Crystallography and molecular interactions
- Marine and fisheries research
- Antimicrobial Peptides and Activities
- Catalytic Cross-Coupling Reactions
- Gallbladder and Bile Duct Disorders
- Bariatric Surgery and Outcomes
- Hepatitis C virus research
- Inhalation and Respiratory Drug Delivery
Medical College of Wisconsin
2020-2024
University at Buffalo, State University of New York
2024
AIDS Prevention Initiative in Nigeria
2023
Janssen Scientific Affairs (United States)
2020-2022
Janssen (United States)
2020-2022
Sheffield Teaching Hospitals NHS Foundation Trust
2014-2021
Royal Hallamshire Hospital
2016-2021
University of Sheffield
1994-2021
Hospital Universitario Puerta del Mar
2021
Creative Research Enterprises (United States)
2021
<b>Objective</b> To evaluate the use of routine laboratory monitoring in terms clinical outcomes among patients receiving antiretroviral therapy (ART) Uganda. <b>Design</b> Randomised trial <b>Setting</b> A home based ART programme rural <b>Participants</b> All participants were people with HIV who members AIDS Support Organisation. Participants had CD4 cell counts <250 cells × 10<sup>6</sup>/L or World Health Organization stage 3 4 disease. <b>Interventions</b> randomised to one three...
Preexposure prophylaxis (PrEP) with emtricitabine plus tenofovir disoproxil fumarate (FTC/TDF) or TDF alone reduces the risk of human immunodeficiency virus (HIV) acquisition. Understanding antiretroviral resistance selected by PrEP during breakthrough infections is important because treatment failure subsequent use.Within largest randomized trial FTC/TDF versus as PrEP, plasma samples were tested for HIV mutations associated FTC (K65R and M184IV) K70E), using 454 sequencing.Of 121...
Quorum sensing (QS) is under the control of N-acylated l-homoserine lactones (AHLs) and their cognate receptors (LuxR-type proteins) in Gram-negative bacteria plays a major role mediating host–bacteria interactions by these species. Certain cyclic dipeptides (2,5-diketopiperazines, DKPs) have been isolated from reported to activate or inhibit LuxR-type proteins AHL biosensor strains, albeit at significantly higher concentrations than native lactones. These reports prompted proposal that DKPs...
SUMMARY Infection by a parasite often induces behavioural changes in the host and these may benefit either or parasite. However, whether are active defence mechanisms parasitic manipulations simply incidental byproducts of infection is not always clear. It has been suggested that understanding proximate as well comparative studies could help distinguish alternatives better. Behavioural fever common response to an many animals we investigated phenomenon novel host-parasite relationship...
Uganda adopted the integrase inhibitor dolutegravir (DTG) as part its preferred first-line HIV treatment regimen in 2018. Prior to national rollout, Ministry of Health and Clinton Access Initiative (CHAI) launched a pilot study July 2017 aimed at better understanding patients' prescribers' experience acceptability DTG. Patients were enrolled if they newly initiating or switched from an NNRTI due intolerance. followed up for 6 months after initiation onto DTG experiences assessed through...
Monitoring of HIV viral load in patients on combination antiretroviral therapy (ART) is not generally available resource-limited settings. We examined the cost-effectiveness qualitative point-of-care tests (POC-VL) sub-Saharan Africa.Mathematical model based longitudinal data from Gugulethu and Khayelitsha township ART programmes Cape Town, South Africa.Cohorts monitored by POC-VL, CD4 cell count or clinically were simulated. Scenario A considered more accurate detection treatment failure...
Small-bowel capsule endoscopy is advocated and repeat upper gastrointestinal (GI) should be considered for evaluation of recurrent or refractory iron deficiency anemia (IDA). A new device that allows magnetic steering the around stomach (magnetically assisted [MACE]), followed by passive small-bowel examination might satisfy both requirements in a single procedure.In this prospective cohort study, MACE esophagogastroduodenoscopy (EGD) were performed patients with IDA. Comparisons total...
Abstract— Cyclic nucleotide phosphodiesterase activity (calcium‐dependent and calcium‐independent) CDR regulator protein of phosphodiesterase) are present in all ten brain regions examined, with the specific both being highest areas predominating grey matter lowest consisting largely white matter. Fractionation cerebral cortex into neuronal glial perikarya shows that cyclic at approximately equal levels cell types. Subcellular fractionation reveals calcium‐sensitive enzyme activity, as well...
OBJECTIVE We investigated direct and indirect relationships between historic redlining prevalence of diabetes in a U.S. national sample. RESEARCH DESIGN AND METHODS Using previously validated conceptual model, we hypothesized pathways structural racism via discrimination, incarceration, poverty, substance use, housing, education, unemployment, food access. combined census tract–level data, including from the Centers for Disease Control Prevention PLACES 2019 database, using Home Owners’ Loan...
To compare continuous to intermittent feeding at delivering prescribed nutrition in hospitalized canine and feline patients.Retrospective clinical study.University teaching hospital.Fifty-four cats 37 dogs.Twenty-four-hour periods of delivered (kcal) were recorded, the percentage (PPND) was calculated. If patient received nasoenteric for >1 day, then average PPND per day Frequency gastrointestinal complications (vomiting, diarrhea, regurgitation) calculated each group. The not significantly...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Cleavage of Trialkylamines by ChloroformatesJ. CampbellCite this: J. Org. Chem. 1957, 22, 10, 1259–1260Publication Date (Print):October 1, 1957Publication History Published online23 April 2003Published inissue 1 October 1957https://doi.org/10.1021/jo01361a606Request reuse permissionsArticle Views138Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both...
Nigeria adopted dolutegravir (DTG) as part of first line (1L) antiretroviral therapy (ART) in 2017. However, there is limited documented experience using DTG sub-Saharan Africa. Our study assessed acceptability from the patient’s perspective well treatment outcomes at 3 high-volume facilities Nigeria. This a mixed method prospective cohort with 12 months follow-up between July 2017 and January 2019. Patients who had intolerance or contraindications to non-nucleoside reverse-transcriptase...
Diketopiperazines (DKPs) are a well-known class of heterocycles that have emerged as promising biologically active scaffolds. Solid-phase organic synthesis has become an important tool in the combinatorial exploration these privileged structures, expediting and, often, discovery compounds. We recently identified several DKPs capable inhibiting luminescence response bacterial symbiont Vibrio fischeri, and we sought to further test scope this biological activity. Herein, report DKP macroarrays...
Mycoplasma pneumoniae has been shown to induce airway inflammation and bronchial hyperresponsiveness (BHR) in mice. Inhaled corticosteroids are the mainstay of asthma treatment, but their effects on M. associated BHR poorly understood.Four groups mice were studied determine whether inhaled fluticasone propionate (FP) could attenuate by reducing or eliminating lungs. The active group received aerosolized FP once daily for 5 days. Control sham solution plus pneumoniae, alone, alone.Mice...
Efficient tagging methodologies are an integral aspect of protein complex characterization by proteomic approaches. Owing to the very high affinity biotin for avidin and streptavidin, biotinylation offers attractive approach efficient purification complexes. The biotin/(strept)avidin system also potential single-step capture lower abundance complexes, such as transcription factor identification short peptide tags that efficiently biotinylated bacterial BirA ligase led complexes specific in...
Background & Aims: Pancreatic exocrine insufficiency may be under recognised in gastroenterological practice. We aimed to identify the prevalence of pancreatic secondary care gastroenterology clinics and determine if co-morbidity or presenting symptoms could predict diagnosis. A aim was assess response treatment.
 Methods: dual centre retrospective analysis conducted clinics. Patients tested for with faecal elastase-1 (FEL-1) between 2009 2013 were identified two centres....
Abstract Background Harm reduction programs are often vulnerable to political and vocal opposition despite documented evidence of their effectiveness economic benefit. It is not well understood if opponents harm represent the general public’s attitudes. Objective To understand attitudes people British Columbia (BC) towards various strategies services, factors associated with support for reduction. Methods A random-digit dialing telephone survey assessing was administered Columbians in August...
Abstract The chlorination and bromination of α‐lithiopyridine 1‐oxides has been studied. Only dihalogenated pyridine are formed. In the case dipyridyl derivatives also formed, and, indeed, predominate. Chloromercuration lithiopyridine gave highly insoluble, unresolvable mixtures pyridylmercury derivatives. These could be brominated readily to give 2‐bromo‐ 2,6‐dibromopyridine 1‐oxides.
Coeliac disease affects 1% of the population but internationally delays in diagnosis are frequent. A relationship between irritable bowel syndrome type symptoms and coeliac is well established most IBS guidelines recommend that patients presenting with should be tested serologically for disease. Seronegative accounts 3-5% all cases it a diagnostic challenge which requires high level clinical suspicion consideration duodenal biopsies prior to confidently excluding this diagnosis. We report...