A5056612230- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Poverty, Education, and Child Welfare
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Mobile Health and mHealth Applications
- Electronic Health Records Systems
- Fungal Infections and Studies
- HIV/AIDS oral health manifestations
- Adolescent and Pediatric Healthcare
- Pharmaceutical Quality and Counterfeiting
- Patient Satisfaction in Healthcare
- Mental Health and Patient Involvement
- Pharmaceutical studies and practices
- COVID-19 Impact on Reproduction
Ministry of Health
2015-2024
Adolescents have gained increased attention because they are the only age group where HIV related mortality is going up. We set out to describe level and factors associated with adherence antiretroviral therapy (ART) as well 1 year retention in care among adolescents 10 representative districts Uganda. In addition, we explored barriers facilitators of ART adolescents.The study involved 30 health facilities from employed both qualitative quantitative data collection methods convergent design....
Although Differentiated Service Delivery (DSD) for anti-retroviral therapy (ART) has been rolled-out nationally in several countries since World Health Organization (WHO)'s landmark 2016 guidelines, there is little research evaluating post-implementation outcomes. The objective of this study was to explore patients' and HIV service managers' perspectives on barriers implementation ART delivery Uganda.We employed a qualitative descriptive design involving 124 participants. Between April June...
Uganda adopted the integrase inhibitor dolutegravir (DTG) as part its preferred first-line HIV treatment regimen in 2018. Prior to national rollout, Ministry of Health and Clinton Access Initiative (CHAI) launched a pilot study July 2017 aimed at better understanding patients' prescribers' experience acceptability DTG. Patients were enrolled if they newly initiating or switched from an NNRTI due intolerance. followed up for 6 months after initiation onto DTG experiences assessed through...
While antiretroviral therapy (ART) availability for HIV patients has increased dramatically in Uganda, patient linkage to and retention care remains a challenge. We assessed patterns of engagement 20 Ugandan health facilities with low based on national reporting.We (defined as registering pre-ART or ART at the facility within 1 month diagnosis) 6-month (having visit 3-6 months after initiation) associations patient-/facility-level factors using multivariate logistic regression.Among 928...
The potential disruption in antiretroviral therapy (ART) services Africa at the start of COVID-19 pandemic raised concern for increased morbidity and mortality among people living with HIV (PLHIV). We describe treatment trends before during interventions implemented to mitigate impact countries supported by US Centers Disease Control Prevention (CDC) through President's Emergency Plan AIDS Relief (PEPFAR).We analysed quantitative qualitative data reported 10,387 PEPFAR-CDC-supported ART...
On January 28, 2003, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), largest commitment by any nation to address a single disease in history, was announced.* In April 2004, first person world receive PEPFAR-supported antiretroviral therapy (ART) man aged 34 years Uganda. Effective ART reduces morbidity and mortality among persons with HIV infection (1) prevents both mother-to-child transmission (MTCT) (2) sexual once viral load is suppressed undetectable levels (<200 copies/mL)...
The World Health Organization (WHO) has published a guideline for the management of individuals with advanced HIV disease (AHD) to reduce HIV-related deaths. consists package recommendations including interventions prevent, diagnose and treat common opportunistic infections, tuberculosis (TB), cryptococcosis severe bacterial along rapid initiation antiretroviral treatment enhanced adherence support. Currently no clear targets exist these key interventions. Emerging programmatic data from...
Abstract Background Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy major public health problem throughout the world. The risk of developing active TB in people living with HIV (PLHIV) is 21 times higher than rest world population. overlap latent infection has resulted marked increases incidence countries dual epidemics. Although antiretroviral therapy (ART) single most significant way to reduce incident PLHIV, besides...
Despite gains in HIV testing and treatment access sub-Saharan Africa, patient attrition from care remains a problem. Evidence is needed of real-world implementation low-cost, scalable, sustainable solutions to reduce attrition. We hypothesized that more proactive follow-up enhanced counseling by health facilities would improve linkage retention. At 20 Central Uganda, we implemented quality improvement intervention package included training lay workers best practices for counseling, including...
Background Tuberculosis (TB) remains the leading cause of death among people living with HIV (PLHIV). To prevent TB PLHIV, Ugandan national guidelines recommend Isoniazid Preventive Therapy (IPT) across differentiated service delivery (DSD) models, an effective way delivering ART. DSD models include Community Drug Distribution Point (CDDP), Client-led ART Delivery (CCLAD), Facility-Based Individual Management (FBIM), Group (FBG), and Fast Track Refill (FTDR). Little is known about impact IPT...
Background: The number of adolescents living with HIV (ALHIV) in Uganda is growing. Improving access to HIV services among this population requires a lot innovation. This study describes service delivery models and innovations improve care and treatment by Uganda. Methods: It was mixed methods which the qualitative aspects included in-depth interviews, Focus Group Discussions Key Informant Interviews various stakeholders. Quantitative data was obtained cross-sectional design using...
Abstract Background Although Differentiated Service Delivery (DSD) for anti-retroviral therapy (ART) has been rolled-out nationally in several countries since World Health Organization (WHO)’s landmark 2016 guidelines, there is little research evaluating post-implementation outcomes. The objective of this study was to explore patients’ and HIV service managers’ perspectives on barriers implementation ART delivery Uganda. Methods We employed a qualitative descriptive design involving 124...
Combination antiretroviral therapy (cART) has massively reduced HIV mortality. However, long-term cART increases the risk of adverse drug reactions (ADRs), which can lead to higher morbidity, mortality and healthcare costs for people living with (PLHIV).Pharmacovigilance-monitoring effects medicines-is essential understanding real-world safety. In Uganda, pharmacovigilance systems have only recently been developed, rates ADR reporting are very low. Thus, safety profile medicines currently...
Although differentiated service delivery (DSD) for HIV treatment was endorsed by the WHO in its landmark 2016 guidelines to lessen patients' need frequently visit clinics and hence reduce unnecessary burdens on health systems, uptake has been uneven globally. This paper is prompted Policy Lab's annual report of 2022 which reveals substantial variations programmatic services across globe. We use Uganda as a case study an 'early adopter' explore drivers novel services.We conducted qualitative...
Because of low pediatric HIV prevalence, more tests are needed to find 1 HIV-positive child compared with adults. In Uganda, the number test (NNT) new was 64 in outpatient departments (OPDs) and 31 through index testing. We aimed develop validate a (1.5-14 years) screening tool optimize testing approaches.Phase evaluated performance 10 questions 14 OPDs using variable selection algorithm evaluate combinations questions. Using logistic regression, we identified best predictive accuracy...
Low retention in care for adolescents living with HIV (ALHIV) has been a key driver of suboptimal viral load suppression rates Uganda. The objective this study was to develop psychosocial risk assessment tool and evaluate its ability predict the attrition ALHIV between ages 15 19 years.
Background In 2019, WHO recommended dolutegravir (DTG) as a backbone for first- and second-line antiretroviral therapy (ART) regimens people living with HIV (PLHIV). According to the 2018 Uganda’s treatment guidelines, patients viral non-suppression (≥1,000 copies/mL) should receive intensive adherence counseling (IAC) repeat load (VL) within 6 months. This analysis focused on prevalence factors associated suppression following IAC among PLHIV DTG-based (DBRs) an initial episode of (VNS) in...
The number of children newly infected with HIV dropped by 50%, from 320 000 in 2010 to 160 2021. Despite progress, ongoing gaps persist diagnosis, continuity care, and treatment optimization. In response, the United States President's Emergency Plan for AIDS Relief created Faith-based Action Scaling-Up Testing Treatment Epidemic Response (FASTER). addressed countries highest unmet need working government operationalize innovative interventions ensure alignment national priorities communities...
Patients have contributed <1% of spontaneous adverse drug reaction (ADR) reports in Uganda's pharmacovigilance database. Peer support combined with mobile technologies could empower people living HIV (PLHIV) to report ADRs and improve ADR management through linkage care. We seek test the feasibility effect a peer intervention on reporting by PLHIV receiving combination antiretroviral therapy (cART) Uganda; identify barriers facilitators intervention; characterise management.This is...
Introduction: Keeping HIV-infected adults away from the health care system during COVID-19 travel restrictions, presents a challenge to HIV treatment adherence.
 Methods: This study focused on initial two phases where Phase 1 designed Makerere College of Health Sciences (MakCHS) Unstructured Supplementary Service Data (USSD)-based application; and 2 piloted patient enrolment onto application determined feasibility remote follow-up patients receiving long-term antiretroviral therapy...
Abstract Background: Although Differentiated Service Delivery (DSD) for anti-retroviral therapy (ART) has been rolled-out nationally in several countries since World Health Organization (WHO)’s landmark 2016 guidelines, there is little research evaluating post-implementation outcomes. The objective of this study was to explore patients’ and HIV service managers’ perspectives on barriers implementation ART delivery Uganda. Methods: We employed a qualitative descriptive design involving 124...
Abstract Background Although Differentiated Service Delivery (DSD) for anti-retroviral therapy (ART) has been rolled-out nationally in several countries since World Health Organization (WHO)’s landmark 2016 guidelines, there is little research evaluating post-implementation outcomes. The objective of this study was to explore patients’ and HIV service managers’ perceptions the early implementation experiences national DSD roll-out across Uganda. Methods We utilized a qualitative design...
Abstract Background Although Differentiated Service Delivery (DSD) for anti-retroviral therapy (ART) has been rolled-out nationally in several countries since World Health Organization (WHO)’s landmark 2016 guidelines, there is little research evaluating post-implementation outcomes. The objective of this study was to explore patients’ and HIV service managers’ perspectives on barriers implementation ART delivery Uganda. Methods We employed a qualitative descriptive design involving 124...
Abstract Introduction Children and adolescents (0-19 years) living with HIV (CALHIV) in Uganda have historically had lower viral load suppression (VLS) rates than adults this was partly attributed to sub-optimal antiretroviral therapy (ART) regimens. By June 2019, less 50% of CALHIV were on optimal regimens despite appropriate policies place. In July Ministry Health (MOH) embarked an ART optimization campaign put all We describe the process, challenges, achievements during 2019 – March 2021....