A5069279475- HIV/AIDS Impact and Responses
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- vaccines and immunoinformatics approaches
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Maternal and Child Health
- Poverty, Education, and Child Welfare
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
Baylor College of Medicine Children’s Foundation
2023-2024
Mulago Hospital
2024
Baylor College of Medicine
2023
Abstract Background Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy major public health problem throughout the world. The risk of developing active TB in people living with HIV (PLHIV) is 21 times higher than rest world population. overlap latent infection has resulted marked increases incidence countries dual epidemics. Although antiretroviral therapy (ART) single most significant way to reduce incident PLHIV, besides...
Efforts towards an effective HIV-1 vaccine have remained mainly unsuccessful. There is increasing evidence for a potential role of HLA-C-restricted CD8+ T cell responses in control, including our recent report HLA-C*03:02 among African children. However, there are no documented optimal epitopes restricted by HLA-C*03:02; additionally, the structural influence on epitope binding undetermined. Immunoinformatics approaches provide fast and inexpensive method to discover HLA-restricted epitopes....
People living with HIV (PLHIV) have a 20-fold risk of tuberculosis (TB) disease compared to HIV-negative people. In 2021, the uptake TB preventive treatment among children and adolescents at Baylor-Uganda clinic was 45%, which below national target 90%. Minimal evidence documents enablers barriers (TPT) initiation completion HIV(CALHIV). We explored facilitators TPT CALHIV aged 10-19years caretakers 18years. conducted qualitative study from February 2022 March 2023, three paediatric...
Abstract Background In July 2022, Uganda’s ministry of Health extended the 2021 WHO guidelines that recommended 3–6 monthly dispensing antiretroviral therapy (ART) to include all children and adolescents living with HIV (CALHIV). Treatment outcomes following this recommendation have not yet been documented. We compared viral load (VL) suppression retention in care rates among CALHIV receiving 1, 2–5 > = 6 ART dispensation Uganda. Methods A cross-sectional study electronic medical records...
In July 2022, Uganda's Ministry of Health extended the 2021 WHO guidelines that recommended 3–6 monthly dispensing antiretroviral therapy (ART) to include all children and adolescents living with HIV (CALHIV). Treatment outcomes following this recommendation have not yet been documented. We compared viral load (VL) suppression retention in care rates among CALHIV receiving 1, 2–5, > = 6 ART dispensation Uganda. A cross-sectional study electronic medical records 118 health facilities was...
Efforts towards an effective HIV-1 vaccine have remained mainly unsuccessful. There is increasing evidence for a potential role of HLA-C-restricted CD8+ T cell responses in control, including our recent report HLA-C*03:02 among African children. However, there are no documented optimal epitopes restricted by HLA-C*03:02; additionally, the structural influence on epitope binding undetermined. Immunoinformatics approaches provide fast and inexpensive method to discover HLA-restricted epitopes....
ObjectiveWe utilize a large retrospective study cohort derived from electronic medical records (EMR) to estimate the prevalence of long-term non-progression (LTNP) and determine factors associated with progression among children infected HIV in Botswana Uganda.MethodsEMRs tertiary clinical centers Uganda were queried identify LTNP 0–18 years enrolled between June 2003 May 2014 extract demographic nutritional parameters. Multivariate subdistribution hazard analyses used examine status pre-ART...
Background: Despite antiretroviral therapy (ART) and prevention of mother-to-child transmission programs, more than 150,000 new HIV infections 99,000 deaths occur annually among children in Africa. Some - long-term nonprogressors (LTNP) can survive for ten years without progressing from infection to AIDS maintain normal CD4+ T-cell counts the absence ART. However, frequency demography pediatric LTNP Africans remains unknown. Here, we utilize a large retrospective study cohort derived...