M. Juliana McElrath
A5084520588- HIV Research and Treatment
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- Reproductive tract infections research
- Hepatitis B Virus Studies
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Animal Virus Infections Studies
- Viral-associated cancers and disorders
- Blood groups and transfusion
Fred Hutch Cancer Center
2016-2025
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2012-2025
University of Washington
2015-2024
Cancer Research Center
2012-2023
South African Tuberculosis Vaccine Initiative
2023
Infectious Disease Research Institute
2008-2023
Beth Israel Deaconess Medical Center
2016-2021
Janssen (Belgium)
2021
Janssen (Netherlands)
2021
Center for Global Health
2021
The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we introduce "weighted-nearest neighbor" analysis, unsupervised framework to learn the relative utility each data type in cell, enabling integrative analysis modalities. We apply our procedure a CITE-seq dataset 211,000 human peripheral blood mononuclear cells (PBMCs) with panels...
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal distributions in which is either strongly non-zero or non-detectable. We propose a two-part, generalized linear model for such data that parameterizes both of these features. argue the cellular detection rate, fraction genes expressed cell, should be adjusted as source nuisance variation. Our provides set enrichment analysis tailored to single-cell data. It...
In the RV144 trial, estimated efficacy of a vaccine regimen against human immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed case–control analysis to identify antibody and cellular immune correlates infection risk.
Efficacious vaccines are urgently needed to contain the ongoing coronavirus disease 2019 (Covid-19) pandemic of infection with severe acute respiratory syndrome 2 (SARS-CoV-2). A candidate vaccine, Ad26.COV2.S, is a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding full-length and stabilized SARS-CoV-2 spike protein.In this multicenter, placebo-controlled, phase 1-2a trial, we randomly assigned healthy adults between ages 18 55 years (cohort 1) those 65 age...
A safe and effective vaccine for the prevention of human immunodeficiency virus type 1 (HIV-1) infection is a global priority. We tested efficacy DNA prime-recombinant adenovirus 5 boost (DNA/rAd5) regimen in persons at increased risk HIV-1 United States.
Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in United States are highly effective, breakthrough infections occurring. Data needed on serial of homologous boosters (same as primary vaccine) and heterologous (different from fully vaccinated recipients.In this phase 1-2, open-label clinical trial conducted at 10 sites States, adults who had completed a Covid-19 vaccine regimen least 12 weeks earlier no reported history...
Early in human immunodeficiency virus type 1 (HIV-1) infection there is a decline viral replication that has been attributed to host immunity, but the components of this response, particularly ability cytotoxic T lymphocytes control burden and influence outcome disease, are poorly understood.
Understanding the initial events in establishment of vaginal human immunodeficiency virus type-1 (HIV-1) entry and infection has been hampered by lack appropriate experimental models. Here, we show an ex vivo organ culture system that upon contact situ, HIV-1 rapidly penetrated both intraepithelial Langerhans CD4(+) T cells. entered cells almost exclusively CD4 CCR5 receptor-mediated direct fusion, without requiring passage from cells, overt productive ensued. By contrast, CD1a(+) primarily...
Phase I studies of volunteers not infected with human immunodeficiency virus type 1 HIV-1) have shown that immunization envelope subunit vaccine products elicits antibodies neutralize laboratory-adapted (prototype) HIV-1 strains in vitro. Prototype are adapted to grow continuous (neoplastic) cell lines and more susceptible neutralization than primary isolates cultured peripheral blood mononuclear cells. In this study, 50 sera from nine phase trials 16 HIV-1-infected persons were evaluated...
Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. Here, we evaluate 254 patients longitudinally up 8 months and find durable broad-based immune responses. SARS-CoV-2 spike binding neutralizing antibodies exhibit a bi-phasic decay with an extended half-life of >200 days suggesting generation longer-lived plasma cells. infection also boosts antibody titers SARS-CoV-1 common betacoronaviruses. In addition, spike-specific IgG+ memory B cells persist, which bodes well...
Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear.
Abstract The simultaneous measurement of multiple modalities, known as multimodal analysis, represents an exciting frontier for single-cell genomics and necessitates new computational methods that can define cellular states based on data types. Here, we introduce ‘weighted-nearest neighbor’ unsupervised framework to learn the relative utility each type in cell, enabling integrative analysis modalities. We apply our procedure a CITE-seq dataset hundreds thousands human white blood cells...
<h3>Importance</h3> Developing effective vaccines against Ebola virus is a global priority. <h3>Objective</h3> To evaluate an adenovirus type 26 vector vaccine encoding glycoprotein (Ad26.ZEBOV) and modified vaccinia Ankara vaccine, glycoproteins from virus, Sudan Marburg Tai Forest nucleoprotein (MVA-BN-Filo). <h3>Design, Setting, Participants</h3> Single-center, randomized, placebo-controlled, observer-blind, phase 1 trial performed in Oxford, United Kingdom, enrolling healthy 18- to...
Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation broadly neutralizing antibodies (bnAbs) against HIV in a large longitudinal cohort HIV-infected individuals. Germinal centers (GCs) perform remarkable task optimizing B-cell Ab responses. GCs are required for almost all receptor affinity maturation and will be critical parameter to monitor if bnAbs induced by vaccination. However, lymphoid tissue is rarely available from...