A5067628638- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Clinical Nutrition and Gastroenterology
- Microscopic Colitis
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Intestinal Malrotation and Obstruction Disorders
- Diverticular Disease and Complications
- Child Nutrition and Feeding Issues
- Liver Disease and Transplantation
- Palliative Care and End-of-Life Issues
- Inflammatory mediators and NSAID effects
- Diagnosis and treatment of tuberculosis
- Pancreatic and Hepatic Oncology Research
- Drug-Induced Adverse Reactions
Sheffield Teaching Hospitals NHS Foundation Trust
2016-2025
Royal Hallamshire Hospital
2015-2024
University of Sheffield
2005-2024
Tianjin Third Central Hospital
2023
Tianjin Medical University
2023
Chinese PLA General Hospital
2023
Amsterdam University Medical Centers
2022
Medtronic (Switzerland)
2021
Fujifilm (Netherlands)
2021
Boston Scientific (United States)
2021
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). The was also reviewed and endorsed by British Gastroenterology (BSG). It addresses roles small-bowel capsule endoscopy device-assisted enteroscopy for diagnosis treatment disorders. <b>Main recommendations</b> <b>1</b> ESGE recommends video as first-line investigation in patients with obscure gastrointestinal bleeding (strong recommendation, moderate quality evidence). <b>2</b> In overt...
<h3>ABSTRACT</h3> Non-steroidal anti-inflammatory drugs (NSAIDs) are used commonly but can cause foregut symptoms, peptic ulcer disease and small bowel enteropathy. Such iatrogenic injury be complicated by gastrointestinal bleeding perforation. Limiting NSAID use or co-administration with proton pump inhibitors (PPIs) reduce dyspepsia, rates of complications. Selective cyclo-oxygenase (COX)-2 as effective adding PPIs in preventing upper lower COX-2 suggested those high cardiovascular risk...
During the COVID-19 pandemic, NHS England introduced colon capsule endoscopy (CCE) at scale to support recovery of endoscopy. Symptomatic patients referred with suspected colorectal cancer (CRC) and a faecal immunochemical test (FIT) ≤ 100 μg Hb/g faeces were offered CCE. To evaluate safety, diagnostic accuracy utility CCE in this setting. Consenting patients, on CRC pathway FIT faeces, CCE, colonoscopy or CT colonography. Each cohort was be age-, sex-, symptom- FIT-matched. We performed...
Background and Study Aims: Recent data suggest that panchromoscopy using methylene blue can improve the detection of intraepithelial neoplastic lesions in context surveillance colonoscopy for patients with chronic ulcerative colitis. This method has also been shown to provide a more accurate diagnosis extent disease inflammatory activity. Interval cancers are known occur colitis despite adoption currently accepted biopsy protocols. We hypothesised targeted chromoscopy alone,...
<b>Objective</b> To determine an effective diagnostic method of detecting all cases coeliac disease in patients referred for gastroscopy without performing routine duodenal biopsy. <b>Design</b> An initial retrospective cohort attending was analysed to derive a clinical decision tool that could increase the detection The incorporated serology (measuring antibodies tissue transglutaminase) and stratifying according their referral symptoms (patients were classified as having “high risk” or...
Abstract The European Society of Gastrointestinal Endoscopy (ESGE) together with the United Gastroenterology (UEG) recently developed a short list performance measures for small-bowel endoscopy (i. e. capsule and device-assisted enteroscopy) final goal providing services across Europe tool quality improvement. Six key both enteroscopy were selected inclusion, intention being that practice at service endoscopist level should be evaluated against them. Other considered to less relevant, based...
<h3>ABSTRACT</h3> Many non-emergency clinical services were suspended during COVID-19 pandemic peak. It is essential to develop a plan for restarting following the equally important protect patients and staff use resources personal protective equipment (PPE) efficiently. The British Society of Gastroenterology Endoscopy Committee Quality Improvement Programme has produced guidance on how restart can be safely delivered. Key recommendations include following: all should have need endoscopy...
Colon capsule endoscopy (CCE) is becoming increasingly popular in Europe. However, development of quality assurance and standardized terminology has not kept pace with clinical integration this technology. As a result, there are significant variations reporting standards, highlighting the need for framework. We used RAND process to achieve consensus experts determine CCE, bowel cleansing assessment, future research priorities. A panel comprising 14 European CCE evaluated 45 statements during...
Background— In the lipopolysaccharide (LPS) stimulated peripheral blood monocyte, precursor form of interleukin 1β (IL-1β, 31 kD) is processed by IL-1β converting enzyme (ICE) to mature, bioactive (17 kD). a proinflammatory cytokine which likely have role in pathogenesis inflammatory bowel disease (IBD). Aims— To investigate expression and processing ICE tissue macrophages from normal IBD colonic mucosa. Methods— Mucosal biopsy specimens lamina propria cells colons were studied reverse...
BACKGROUND In hereditary nonpolyposis colorectal cancer flat and diminutive adenomas occur, particularly in the right colon. Such lesions may assume a high risk of malignant transformation. Interval cancers are known to occur this group. Chromoscopic colonoscopy enhances detection patients assuming moderate lifetime cancer. AIM To prospectively assess efficacy high-magnification-chromoscopic for neoplastic undergoing screening. METHODS Twenty-five asymptomatic fulfilling modified Amsterdam...
The potential of endoscopic mucosal resection (EMR) for treating flat dysplastic lesions in chronic ulcerative colitis (CUC) has not been addressed so far. Historically, such were referred colectomy. Furthermore, there are only limited data to support exophytic adenoma-like mass (ALM) colitis.To evaluate the safety and clinical outcomes patients with undergoing EMR Paris class 0-II I ALM compared sporadic controls. Secondary aims re-evaluate prevalence, anatomical "mapping" histopathological...
Small bowel disease in the paediatric population is varied and to date has relied on indirect l modalities such as small follow-through with attendant radiation exposure. Wireless capsule endoscopy (WCE) potential provide a safer more effective means of investigating bowel. The aim our study was prospectively assess diagnostic yield WCE compared standard investigation children suspected disease.Twenty-eight consecutive patients, median age 12.5 y (range, 9.4-15.9) were investigated WCE. This...
Video capsule endoscopy (VCE) is an attractive method for diagnosing and objectively monitoring disease activity in celiac (CeD). Its use, facilitated by artificial intelligence- based tools, may allow computer-assisted interpretation of VCE studies, transforming a subjective test into quantitative reproducible measurement tool.To evaluate compare objective CeD severity assessment as determined with expert human readers machine learning algorithm (MLA).Patients ≥ 18 years histologically...
The relationship between coeliac disease and inflammatory bowel (IBD) is controversial. aim of this study was to determine the prevalence in IBD disease.Patients were enrolled from specialist clinics. Antigliadins, endomysial, tissue transglutaminase antibody total IgA levels measured patients. Patients with positive antibodies offered a duodenal biopsy. notes on patients reviewed for colonoscopic biopsy findings. Controls recruited local population.The included 305 disease, 354 601 healthy...
Patients with coeliac disease may have diarrhoea despite being on a gluten-free diet.To assess whether exocrine pancreatic insufficiency causes persisting symptoms compared controls, we determined enzyme supplementation provided symptomatic benefit in patients chronic diarrhoea.Patients (n = 259) were subdivided into four groups: (a) new 57), (b) diet without gastrointestinal 86), (c) 66) and (d) 50). Stool frequency weight, before after treatment recorded.The prevalence of low faecal...
Background and aim An increased prevalence of reflux irritable bowel syndrome (IBS) symptoms is associated with coeliac disease inflammatory (IBD). We aimed to determine the IBS in a cohort patients IBD their relationship quality life (QoL) psychological distress. Methods Histologically proven (n=225), ulcerative colitis (UC) (n=228), Crohn's (CD) (n=230) age/sex-matched controls (n=348) completed Short-Form 36 (SF-36)-Item Health Survey, Hospital Anxiety Depression Scale (HADS), screen Rome...