A5033315037- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Medical Imaging Techniques and Applications
- Hemophilia Treatment and Research
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- AI in cancer detection
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Maritime Navigation and Safety
- Ultrasound Imaging and Elastography
- Meta-analysis and systematic reviews
- Drug Transport and Resistance Mechanisms
- Statistical Methods and Inference
- Treatment of Major Depression
- Underwater Acoustics Research
- Glioma Diagnosis and Treatment
Takeda (United States)
2021-2024
Takeda (Japan)
2024
Bristol-Myers Squibb (United States)
2018
Innovation Center of NanoMedicine
2015
Pfizer (United States)
2004-2013
Novartis (United States)
2007
KDS Development (United States)
2005
University of Connecticut
2002
Thirty-two structurally diverse drugs used for the treatment of various conditions central nervous system (CNS), along with two active metabolites, and eight non-CNS were measured in brain, plasma, cerebrospinal fluid P-glycoprotein (P-gp) knockout mouse model after subcutaneous administration, data compared corresponding obtained wild-type mice. Total brain-to-plasma (B/P) ratios CNS agents ranged from 0.060 to 24. Of 34 CNS-active agents, only 7 demonstrated B/P area under plasma...
Although investigators in the imaging community have been active developing and evaluating quantitative biomarkers (QIBs), development implementation of QIBs hampered by inconsistent or incorrect use terminology methods for technical performance statistical concepts. Technical is an assessment how a test performs reference objects subjects under controlled conditions. In this article, some relevant concepts are reviewed, that can be used comparing described, issues related to discussed. More...
Abstract INTRODUCTION Blood tests have the potential to improve accuracy of Alzheimer's disease (AD) clinical diagnosis, which will enable greater access AD‐specific treatments. This study compared leading commercial blood for amyloid pathology and other AD‐related outcomes. METHODS Plasma samples from Disease Neuroimaging Initiative were assayed with AD C2N Diagnostics, Fujirebio ALZPath, Janssen, Roche Quanterix. Outcomes measures positron emission tomography (PET), tau PET, cortical...
Essentials High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial late/tertiary vs on-demand therapy. Prophylaxis improved function, quality life, activity pain but not joint structure by MRI. improves function must start before bleeding onset to prevent arthropathy.Background Limited exist the impact severe A pre-existing disease. Objectives To describe bleeding, health structure, health-related...
This report details the approach taken to providing a dataset allowing for analyses on performance of recently developed assays amyloid beta (Aβ) peptides in plasma and extent which they improve prediction positivity.
Regulatory qualification of a biomarker for defined context use provides scientifically robust assurances to sponsors and regulators that accelerate appropriate adoption biomarkers into drug development.The Coalition Against Major Diseases submitted dossier the Scientific Advice Working Party European Medicines Agency requesting opinion on hippocampal volume as enriching clinical trials in subjects with mild cognitive impairment, incorporating scientific rationale, literature review de novo...
The development of novel treatments for many slowly progressing diseases, such as Alzheimer's disease (AD), is dependent on the ability to monitor and detect changes in progression. In some diseases distinct clinical stages progress far too enable a quick evaluation efficacy given proposed treatment. To help improve assessment progression, we propose using Hidden Markov Models (HMM's) model, more granular fashion, progression compared disease. Unlike other applications Models, train our HMM...
Video capsule endoscopy (VCE) is an attractive method for diagnosing and objectively monitoring disease activity in celiac (CeD). Its use, facilitated by artificial intelligence- based tools, may allow computer-assisted interpretation of VCE studies, transforming a subjective test into quantitative reproducible measurement tool.To evaluate compare objective CeD severity assessment as determined with expert human readers machine learning algorithm (MLA).Patients ≥ 18 years histologically...
Clinically observed drug interactions with cytochrome P450 (P450) enzymes have increased the need to assess of new chemical entities early in discovery process. To meet this need, fluorogenic substrates been commercialized. However, only limited evaluations their utility and comparisons probes reported. This study examines correlation between IC<sub>50</sub> values obtained conventional for structurally diverse inhibitors five major human isoforms. In general, correlations are weak,...
Methods to correct the QT interval for heart rate are often in disagreement and may be further confounded by changes autonomic state. This can problematic when trying distinguish either drug-induced delayed repolarization or from autonomic-mediated physiological responses. Assessment of canine dynamic QT-RR relationship was visualized novel programming beat-to-beat confluence data "clouds". To represent nonuniformity clouds, a bootstrap sampling method that computes mathematical center...
Introduction: Blood tests have the potential to improve accuracy of Alzheimer disease (AD) clinical diagnosis, which will enable greater access AD-specific treatments. This study compared leading commercial blood for amyloid pathology and other AD-related outcomes. Methods: Plasma samples from Alzheimers Disease Neuroimaging Initiative were assayed with AD C2N Diagnostics, Fujirebio ALZPath, Janssen, Roche Quanterix. Outcomes measures positron emission tomography (PET), tau PET, cortical...
Abstract Purpose To evaluate the contribution to scan‐rescan coefficient of variation (CV) patient‐specific arterial input function (AIF) measurement in dynamic contrast‐enhanced MRI (DCE‐MRI) data, and determine whether any advantage or disadvantage using a data‐derived is related anatomical location target lesion. Materials Methods Two methods are presented for calculation perfusion parameters from DCE‐MRI data two‐compartment model. The first method makes use single‐model AIF across all...
Dynamic contrast-enhanced MRI (DCE-MRI) is a potentially useful noninvasive technique for assessing tissue perfusion, particularly in the context of solid tumors and targeted antiangiogenic antivascular therapies. Our aim was to determine reproducibility perfusion parameters derived at DCE-MRI lung liver, most common sites metastasis.Patients with liver underwent two sequential examinations 2-7 days apart without any intervening therapy. The volume transfer constant between blood plasma...
A framework for developing evidentiary standards qualification of biomarkers is a key need identified in the Food and Drug Administration's Critical Path Initiative.1 This article describes systematic that was developed by Pharmaceutical Research Manufacturers America (PhRMA) committees tested at workshop collaboration with Administration academia. With some necessary refinements, this could be applied to create an appropriately individualized standard any biomarker purpose. Clinical...
Abstract Background Low HCV has recently been qualified by the European Medicines Agency as a biomarker for enrichment of clinical trials in predementia stages Alzheimer's disease. For automated methods to meet necessary regulatory requirements, it is essential they be standardized and their performance well characterized. Methods The within‐image between‐field strength reproducibility hippocampal volumetry using Learning Embeddings Atlas Propagation (or LEAP) algorithm was assessed on 153...
QT interval prolongation of the electrocardiogram has been associated with occurrence life-threatening fatal ventricular arrhythmias. To understand relationship between preclinical cardiac conduction assessment to clinical outcome, comparisons free (unbound)-plasma drug concentrations and their effects in conscious mongrel dog were made plasma humans reported produce prolongation. E-4031 (an experimental class III antiarrhythmic), cisapride, terfenadine, terodiline, verapamil all affect...
Background: 5-HT 4 receptors in cortex and hippocampus area are considered as a possible target for modulation of cognitive functions Alzheimer's disease (AD).A systems pharmacology approach was adopted to evaluate the potential providing beneficial effects on cognition AD.Methods: A serotonergic synaptic cleft model developed by integrating serotonin firing, release, half-life, drug/tracer properties (affinity agonism) inputs activity output.The calibrated using both vivo data free levels...
Mealey, K.L., Waiting, D., Raunig, D.L., Schmidt, K.R., Nelson, F.R. Oral bioavailability of P‐glycoprotein substrate drugs do not differ between ABCB 1‐1Δ and 1 wild type dogs. J. vet. Pharmacol. Therap . 33 , 453–460. Previous studies have indicated that intestinal (P‐gp) limits the oral alters systemic pharmacokinetics. In this study, dogs lacking functional P‐gp were used to determine contribution pharmacokinetics several drugs. The substrates quinidine, loperamide, nelfinavir,...