A5048322247- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- IgG4-Related and Inflammatory Diseases
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Pharmacology and Obesity Treatment
- Bariatric Surgery and Outcomes
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Global Cancer Incidence and Screening
Erasmus MC
2015-2024
Erasmus University Rotterdam
2010-2024
Erasmus MC Cancer Institute
2021-2024
New York University
2024
Yale University
2024
Rotterdam University of Applied Sciences
2024
Ziekenhuis Amstelland
2008-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
RELX Group (Netherlands)
2019
For patients with chronic pancreatitis and a dilated pancreatic duct, ductal decompression is recommended. We conducted randomized trial to compare endoscopic surgical drainage of the duct.
The International Cancer of the Pancreas Screening Consortium met in 2018 to update its consensus recommendations for management individuals with increased risk pancreatic cancer based on family history or germline mutation status (high-risk individuals).A modified Delphi approach was employed reach among a multidisciplinary group experts who voted statements. Consensus considered reached if ≥75% agreed disagreed.Consensus 55 main goals surveillance (to identify high-grade dysplastic...
We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.From 2006 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, subjected them annual both endoscopic ultrasonography (EUS) MRI/cholangiopancreatography (MRI/MRCP) at each visit.366 (201 mutation-negative familial (FPC)...
Background and Study Aims: Endoscopic drainage is a widely used treatment modality for pancreatic pseudocysts has challenged more traditional techniques. This retrospective study evaluates the short-term long-term results with this technique aims to identify procedural modifications that may improve its safety efficacy. Patients Methods: All consecutive patients who underwent endoscopic of in our hospital between 1983 2000 were included study. The patients' charts reviewed, follow-up data...
Glucagon-like peptide (GLP)-1-based therapies have been suggested to improve hepatic steatosis. We assessed the effects of GLP-1 receptor agonist liraglutide and dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin on steatosis fibrosis in patients with type 2 diabetes.In this 12 week, parallel, randomised, placebo-controlled trial, performed at VU University Medical Center between July 2013 August 2015, 52 overweight diabetes treated metformin and/or sulphonylurea agent ([mean ± SD] age 62.7...
To successfully implement imaging-based pancreatic cancer (PC) surveillance, understanding the timeline and morphologic features of neoplastic progression is key. We aimed to investigate neoplasia from serial prediagnostic imaging tests in high-risk individuals identify factors associated with successful early detection.We retrospectively examined development abnormalities who were diagnosed PC or underwent surgery, both, 16 international surveillance programs.Of 2552 under 28 (1%) developed...
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
In cancer of the pancreatic head region, exocrine insufficiency is a well-known complication, leading to steatorrhea, weight loss, and malnutrition. Its presence frequently overlooked, however, because primary attention focused on treatment. To date, risk developing unspecified. Therefore, we assessed this function in patients with tumors head, distal common bile duct, or ampulla Vater.Between March 2010 August 2012, prospectively included diagnosed region at our tertiary center. preclude...
After pancreatic surgery, up to 80 % of patients will develop exocrine insufficiency. For enzyme supplementation be effective, prescribing an adequate dose enzymes is mandatory but challenging because the required varies. Data on practice replacement therapy after surgery are lacking, and therefore, we conducted this analysis.
Abstract Background Exocrine insufficiency frequently develops in patients with pancreatic cancer owing to tumour ingrowth and duct obstruction. Surgery might restore this function by removing the primary disease restoring patency, but it may also have opposite effect, as a result of resection functional parenchyma anatomical changes. This study evaluated course function, before after resection. Methods prospective cohort included tumours region requiring tertiary referral centre between...
Although Endoscopic Ultrasound (EUS)-guided tissue sampling is widely used, the optimal strategy remains subject of debate. We evaluated practice patterns within international endosonographic community.An online questionnaire was sent to 400 endosonographers from United States, Europe, and Asia.A total 186 (47 %) participated: States 54 (29 %), Europe 85 (46 Asia 47 (25 %). European (75 Asian (84 respondents routinely check coagulation status, whereas US only on indication (64 %, P = 0.007)....
Background & AimsIndividuals with obesity may develop intrapancreatic fat deposition (IPFD) and fatty pancreas disease (FPD). Whether this causes inflammation fibrosis leads to pancreatic dysfunction is less established than for liver damage in metabolic dysfunction-associated steatotic (MASLD). Moreover, the interrelations of FPD MASLD are poorly understood. Therefore, we aimed assess IPFD fibro-inflammation relation function severity individuals MASLD.MethodsSeventy-six participants from...