A5091021109- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Glioma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Immune cells in cancer
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Adenosine and Purinergic Signaling
Sahlgrenska University Hospital
2021-2025
University of Gothenburg
2021-2025
Karolinska Institutet
2015-2024
Karolinska University Hospital
2008-2023
Umeå University
2020
Regional Cancer Center
2020
Wellcome Trust
2019
Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in stroma ductal adenocarcinomas and besides their pathological release extracellular matrix proteins, they also perceived as key contributors to immune evasion. Despite known relevance tumor infiltrating lymphocytes cancers, interactions between T-cells CAFs remain largely unexplored. Here, we found that isolated from tumors cancer patients undergoing surgical resection (n = 15) expressed higher levels PD-1...
Objective: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: Coupled improvements in chemotherapy radiation, contemporary approach to surgery supports resection BR-PDAC and, a lesser extent, LA-PDAC. Guidelines outlining selection for these are lacking. Methods: Scottish Intercollegiate Network (SIGN)...
Objective: Neoadjuvant therapy (NAT) has become part of the multimodality treatment for borderline resectable pancreatic cancer (BRPC) and locally advanced (LAPC). Summary Background Data: It is currently uncertain which are preferable NAT regimens, who benefits from surgery, whether more aggressive surgical strategy motivated. Methods: A retrospective cohort analysis was performed all patients with BRPC/LAPC discussed planned at multidisciplinary conference Karolinska University Hospital...
Few studies have investigated the outcome of pancreatectomy associated with artery resection (PAR).Retrospective analysis a cohort operated borderline or locally advanced pancreatic cancer patients surgically confirmed arterial involvement. Short and long-term were analyzed compared in who underwent PAR (Group 1) palliative surgery 2).Of 73 surgical exploration intent resection, 34 (±venous resection) 39 palliation 2). 23 (67.7%) Group 1 combined artery-vein (AVR). Operation time was longer...
While surveillance of the majority patients with IPMN is considered best practice, consensus regarding duration follow-up lacking. This study assessed survival rate and risk for progression under surveillance. All diagnosed surveyed between January 2008 December 2013 were identified assigned to two groups: without indication surgery (Group 1), whose required but inoperable general reasons 2). Disease data compared both groups. In total 503 identified, whom 444 (88.3%) followed up. Group 1...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
Generation of T lymphocytes with reactivity against cancer is a prerequisite for effective adoptive cellular therapies. We established protocol tumor-infiltrating (TILs) from patients pancreatic ductal adenocarcinoma. Tumor samples 17 specimens were cultured cytokines (IL-2, IL-15, and IL-21) to expand TILs. After 10 days culture, TILs stimulated an anti-CD3 antibody (OKT3) irradiated allogeneic peripheral blood mononuclear cells. Reactivity tumor-associated antigens (mesothelin, survivin,...
Tumor-infiltrating lymphocytes (TILs) may represent a viable source of T cells for the biological treatment patients with gliomas. Glioma tissue was obtained from 16 patients, tumor cell lines were established, and TILs expanded in 16/16 cases using combination IL-2/IL-15/IL-21. Intracellular cytokine staining (ICS, IL-2, IL-17, TNFα IFNγ production) as well cytotoxicity assay used to detect TIL reactivity against autologous or shared tumor-associated antigens (TAAs; i.e., NY-ESO-1, Survivin...
Abstract The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact calcipotriol, a vitamin D 3 analogue, on activation human CAFs T cells using 2- 3-dimensional (2D, 3D) cell culture models. We found that calcipotriol decreased CAF proliferation migration reduced release pro-tumorigenic factors prostaglandin E 2 , IL-6, periostin, leukemia inhibitory factor. However,...
Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess diagnostic yield clinical impact intraoperative in patients operated on MD MT-IPMNs. This retrospective cohort study. Patients undergoing surgery or MT-IPMN underwent frozen section analysis. In all who required extended due pancreatoscopic findings, we compared...
Abstract Background The use of prophylactic abdominal drainage following pancreaticoduodenectomy (PD) is controversial as its therapeutic value uncertain. However, the diagnosis postoperative pancreatic fistula (POPF), main cause PD-associated morbidity, often based on drain amylase (DPA) levels. aim this study was to assess predictive DPA, plasma (PPA) and serum C-reactive protein (CRP) for diagnosing POPF after PD. Methods Patients undergoing PD with between 2008 2012 were studied...
Background: Delayed gastric emptying (DGE) frequently complicates pancreatoduodenectomy (PD). Mainly DGE develops as consequence of postoperative intra-abdominal complications (secondary), whilst the incidence primary (i.e. not related to surgical complications) has rarely been studied. Moreover pathogenesis is complex and needs be further elucidated. The present study aimed at highlighting potential mechanisms behind above all secondary by studying a variety different pancreatic procedures....
The need for a common education and training track in surgical oncology across Europe has been emphasized. ESSO provides several hands-on courses skills face-to-face discussions. core curriculum framework the overall theoretical requirements oncology. UEMS/EBSQ fellowship exam is designed to test competencies candidate's knowledge their prespecified area of expertise. A set points each cancer type lacking. Hence, condensed outline themed expected be covered relevant an optimal practice...
Indocyanine green (ICG) is one of the only clinically approved near-infrared (NIR) fluorophores used during fluorescence-guided surgery (FGS), but it lacks tumor specificity for pancreatic ductal adenocarcinoma (PDAC). Several tumor-targeted fluorescent probes have been evaluated in PDAC patients, yet no uniformity or consensus exists among surgical community on current and future needs FGS surgery. In this first-published report PDAC, expert opinions were gathered use recommendations from...