Ernesto Sparrelid
A5032951554- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Liver Diseases and Immunity
Karolinska Institutet
2016-2025
Karolinska University Hospital
2016-2025
Sorbonne Université
2025
Pitié-Salpêtrière Hospital
2025
Assistance Publique – Hôpitaux de Paris
2025
Essen University Hospital
2024
Erasmus MC
2024
Cambridge University Hospitals NHS Foundation Trust
2023
Oslo University Hospital
2020
University of Copenhagen
2020
The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage (TSH) in a randomized controlled trial (RCT).Radical metastasis offers only chance cure patients metastatic colorectal cancer. Patients (CRLM) an insufficient future remnant (FLR) volume are traditionally treated chemotherapy embolization or followed by (TSH). This treatment sometimes fails due growth tumor...
Abstract Background Posthepatectomy liver failure (PHLF) contributes significantly to morbidity and mortality after surgery. Standardized assessment of preoperative function is crucial identify patients at risk. These European consensus guidelines provide guidance for patient assessment. Methods A modified Delphi approach was used achieve consensus. The expert panel consisted hepatobiliary surgeons, radiologists, nuclear medicine specialists, hepatologists. guideline process supervised by a...
LBA4005 Background: Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) has shown improved survival in metastatic pancreatic cancer, promising results as downstaging chemotherapy locally advanced cancer. The efficacy of neoadjuvant FOLFIRINOX patients with resectable cancer is unknown. Methods: This a randomized phase II trial included from 12 Nordic centers the period 2017-2021. Patients head were randomly assigned to receive either four cycles followed by surgery eight...
Objective: The aim of this study was to compare the perioperative outcomes robotic liver surgery (RLS) and laparoscopic (LLS) in various settings. Summary Background Data: Clear advantages RLS over LLS have rarely been demonstrated, associated costs are generally higher than those surgery. Therefore, exact role approach minimally invasive remains be defined. Methods: In international retrospective cohort study, patients who underwent for all indications between 2009 2021 34 hepatobiliary...
Objective: To evaluate the oncological outcome for patients with colorectal liver metastases (CRLM) randomized to associating partition and portal vein ligation staged hepatectomy (ALPPS) or 2-stage (TSH). Background: TSH occlusion is an established method CRLM a low volume of future remnant (FLR). ALPPS less method. The these methods has not been previously compared in controlled trial. Methods: One hundred standardized FLR (sFLR) <30% were included resection by TSH, option rescue group,...
Abstract Background A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality long-term survival versus resections for pCCA. Methods Patients who underwent major pCCA at 25 Western centers were stratified according to the type hepatectomy—left, extended left, right, right. The primary outcomes 90-day overall (OS). Results Between...
To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with vein (PMV) involvement. Current comparative studies on PVR as part of include all degrees PMV involvement, including cases where may not be a feasible approach, limiting the clinical applicability. International retrospective study 10 centers from 5 countries, consecutive after ≤180°...
Abstract Background Preoperative portal vein embolization (PVE) is frequently used to improve future liver remnant volume (FLRV) and reduce the risk of failure after major resection. Objective This paper aimed assess postoperative outcomes PVE resection for suspected perihilar cholangiocarcinoma (PHC) in an international, multicentric cohort. Methods Patients undergoing PHC across 20 centers worldwide, from year 2000, were included. Liver failure, biliary leakage, hemorrhage classified...
Bile ducts from patients with PSC are enriched in neutrophils and biliary-resident CD8 + T cells differ composition liver tissue.
Abstract Background Post-hepatectomy liver failure (PHLF) is one of the most serious postoperative complications after hepatectomy. The aim this study was to assess impact International Study Group Liver Surgery (ISGLS) definition PHLF on morbidity and short- long-term survival major Methods This a retrospective review all patients who underwent hepatectomy (three or more segments) for various tumours between 2010 2018 at two Swedish tertiary centres hepatopancreatobiliary surgery....
Abstract Background Highly utilized risk scores for clinically relevant postoperative pancreatic fistula (CR-POPF) have guided clinical decision-making in pancreatoduodenectomy. However, none has been successfully developed distal pancreatectomy. This study aimed to develop and validate a new score Methods Patients undergoing pancreatectomy at Helsinki University Hospital, Finland from 2013 2021, Karolinska Sweden, 2010 2020, were included retrospectively. The outcome was CR-POPF, according...
While resection remains the only curative option for perihilar cholangiocarcinoma, it is well known that such surgery associated with a high risk of morbidity and mortality. Nevertheless, beyond facing life-threatening complications, patients may also develop early disease recurrence, defining "futile" outcome in cholangiocarcinoma surgery. The aim this study to predict high-risk category (futile group) where surgical benefits are reversed alternative treatments be considered.
Despite a fast and potent growth of the future liver remnant (FLR), patients operated with associating partition portal vein ligation for staged hepatectomy (ALPPS) are at risk developing posthepatectomy failure. In this study, relation between volume function in ALPPS was studied using multimodal assessment.
Although Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) is no longer considered a contraindication for curative surgery, few data are available from Western series to indicate the outcomes these patients. This study aimed compare short- and long-term patients with BC versus types 2 3 pCCA undergoing surgical resection using multi-institutional international database.Uni- multivariable analyses of surgery at 20 centers pCCA.Among 1138 included in study, 826 (73%) had or...
Total pancreatectomy (TP) is mentioned as alternative to pancreatoduodenectomy (PD) with high-risk pancreatojejunostomy (PJ) avoid severe pancreatic fistula-related complications, but its benefit controversial and comparative studies are scarce.Cross-sectional single-center study among patients after PD PJ versus single-stage elective TP for any indication (2015-2017), using propensity scores evaluate surgical outcomes long-term quality of life (QoL) in three risk strata. EORTC QLQ-C30...