A5048970753- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Genetic and Kidney Cyst Diseases
- Organ Donation and Transplantation
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Abdominal Trauma and Injuries
- Colorectal Cancer Surgical Treatments
Asklepios Klinik Barmbek
2016-2025
Asklepios
2012-2024
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2011-2024
German Society of Surgery
2002-2024
Mammazentrum Hamburg
2022
Semmelweis University
2017-2022
Asklepios
2022
Universität Hamburg
2021
Asklepios Klinik St. Georg
2020
Neurological Surgery
2020
Objective: The aim of this study was to define robust benchmark values for the surgical treatment perihilar cholangiocarcinomas (PHC) enable unbiased comparisons. Background: Despite ongoing efforts, postoperative mortality and morbidity remains high after complex liver surgery PHC. Benchmark data best achievable results in PHC are however still lacking. Methods: This analyzed consecutive patients undergoing major 24 high-volume centers 3 continents over recent 5-year period (2014–2018) with...
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine individual proteins. The different proteins generated exon-sharing, which results in production family contain identical, 245-amino acid, carboxyl-terminal domains and an amino-terminal region approximately 280 amino acids. diversity the<i>UGT1A</i> suggests complex regulation, most likely designed to account for variable specific glucuronidation requirements. However,...
Abstract BACKGROUND In the past 20 years, a dramatic improvement in prognosis of patients with hepatoblastoma (HB) has been achieved by combining surgery chemotherapy several national and international trials. A worldwide, unsolved problem remains treatment advanced or metastatic HB. METHODS The German Cooperative Pediatric Liver Tumor Study HB 94 was prospective, multicenter, single‐arm study. study ran from January 1994 to December 1998. protocol assessed efficiency consisting cisplatin,...
Tumor recurrence is the major limitation of long-term survival after liver transplantation for hepatocellular carcinoma (HCC) or fibrolamellar (FLC). Understanding tumor-biologic characteristics important selection patients and development adjuvant therapeutic strategies.The study included 69 who underwent potentially curative HCC/FLC survived more than 150 days; minimum follow-up was 33 months. Frequency, localization, timing were analyzed compared with primary tumor patient...
To longitudinally assess whether risk adjustment in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) occurred over time is associated with postoperative outcome.ALPPS a novel 2-stage hepatectomy enabling resection of extensive hepatic tumors. ALPPS has been criticized its high mortality, which reported beyond accepted standards liver surgery. Therefore, adjustments patient selection technique have performed but not yet studied relation to centers the...
To create a prediction model identifying futile outcome in ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy) before stage 1 2 surgery.ALPPS is 2-stage hepatectomy, which incorporates parenchymal transection at enabling resection of extensive liver tumors. One the major criticisms associated high mortality rate up to 20%.Using International Registry, risk analysis (defined as 90-day or in-hospital mortality) was performed. Futility modeled using multivariate...
Oldhafer, Karl J. MD; Stavrou, Gregor A. van Gulik, Thomas M. MD on behalf of the Core Group Author Information
Objectives: To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients colorectal liver metastases (CRLM) undergoing ALPPS. Background: ALPPS is two-stage hepatectomy variant that increases resection rates and R0 primarily unresectable CRLM as evidenced recent randomized controlled trial. Long-term oncologic results, however, are lacking. Methods: Cases in- outside the International Registry were collected completed by direct contacts to centers...
Little is known about the composition of intrahepatic immune cells and their contribution to pathogenesis primary sclerosing cholangitis (PSC). Herein, we aimed create an atlas T thereby perform in-depth characterization in inflamed human liver.Different single-cell RNA sequencing methods were combined with silico analyses on peripheral from patients PSC (n = 11) healthy donors (HDs, n 4). Multi-parameter flow cytometry functional vitro experiments conducted samples 24), controls other liver...
Auxiliary liver transplantation (LT) is a special procedure of LT which could be proposed to patients with fulminant hepatic failure (FHF) and has for aim that complete regeneration the native (NL) left in place will allow graft recipient resume normal function after allograft withdrawal. We report 30 cases auxiliary performed FHF 12 European centers. Twenty-five were younger than 50 years. The cause was hepatitis A virus (HAV) 4 patients, B (HBV) 7, paracetamol overdose 5, ecstasy 2,...
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease associated in 10% to 36% of those with hepatobiliary malignancies, which are, the majority cases, not known prior transplantation. Diagnosis carcinomas PSC setting at an early stage has yet been achieved, because there are no differences age patients or clinical course, particularly regard time between diagnosis and detection carcinomas. To assess optimal timing for transplantation PSC, we applied Mayo survival model 48...
The aim of this study was to use the concept benchmarking establish robust and standardized outcome references after procedure ALPPS (Associating Liver Partition Portal Vein Ligation for Staged hepatectomy).The recently developed procedure, aiming at removing primarily unresectable liver tumors, has been criticized safety issues with high variations in reported morbidity/mortality rates depending on patient, disease, technical characteristics, center experience. No reference values relevant...
Metabolism is a critical basis for immune cell functionality. It was recently shown that NK subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating cells can adjust to changes in metabolic requirements. As availability and tissues significantly differ, we examined isolated paired blood-liver blood-spleen samples compared the transporters Glut1, CD98 CD71. CD56bright tissue-resident (CXCR6+) derived livers spleens expressed...
The coronavirus disease 2019 (COVID-19) pandemic affects the education of medical students around world and countries have had differing responses in dealing with this dynamic situation. role fighting is controversial it yet to be elucidated how they can best service. aim study evaluate working fields volunteering impact on final year from a student's perspective.An anonymous online survey was conducted amongst 219 Hamburg (Germany), using an institutional data collection program.A total 137...