A5084843997- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic function and diabetes
- Cardiac Ischemia and Reperfusion
- Pediatric Hepatobiliary Diseases and Treatments
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Adipose Tissue and Metabolism
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Anesthesia and Neurotoxicity Research
University Hospital Schleswig-Holstein
2021-2024
University of Lübeck
2021-2024
Universitäts Hautklinik Kiel
2024
University Medical Center
2024
University Hospital of Zurich
2013-2023
University of Geneva
2022
National Institute of Health
2022
Creative Research Enterprises (United States)
2022
St. Vincent's University Hospital
2022
National Centre for Infectious Diseases
2022
To longitudinally assess whether risk adjustment in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) occurred over time is associated with postoperative outcome.ALPPS a novel 2-stage hepatectomy enabling resection of extensive hepatic tumors. ALPPS has been criticized its high mortality, which reported beyond accepted standards liver surgery. Therefore, adjustments patient selection technique have performed but not yet studied relation to centers the...
Allocation of liver grafts triggers emotional debates, as those patients, not receiving an organ, are prone to death. We analyzed a high-Model End-stage Liver Disease (MELD) cohort (laboratory MELD score ≥30, n = 100, median laboratory 35; interquartile range 31-37) transplant recipients at our center during the past 10 years and compared results with low-MELD group, matched by propensity scoring for donor age, recipient cold ischemia time. End points study were cumulative...
To create a prediction model identifying futile outcome in ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy) before stage 1 2 surgery.ALPPS is 2-stage hepatectomy, which incorporates parenchymal transection at enabling resection of extensive liver tumors. One the major criticisms associated high mortality rate up to 20%.Using International Registry, risk analysis (defined as 90-day or in-hospital mortality) was performed. Futility modeled using multivariate...
Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications clinical scenarios, leading to steady improvements safety. This report presents the current status of ALPPS.ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety oncologic benefits.During 12th biennial congress European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th...
Serotonin dampens tumor-specific immunity in pancreatic and colorectal cancer mouse models.
Objectives: To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients colorectal liver metastases (CRLM) undergoing ALPPS. Background: ALPPS is two-stage hepatectomy variant that increases resection rates and R0 primarily unresectable CRLM as evidenced recent randomized controlled trial. Long-term oncologic results, however, are lacking. Methods: Cases in- outside the International Registry were collected completed by direct contacts to centers...
Abstract Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at advanced stage. The aim study was verify surgical oncological outcome for intrahepatic cholangiocarcinoma (ICC). Methods cohort based on registry with patients from 31 international centers between August 2009 January 2018. Propensity score matched receiving chemotherapy only were selected SEER database as controls survival analysis. Results One hundred two undergoing recruited, 99...
The aim of this study was to use the concept benchmarking establish robust and standardized outcome references after procedure ALPPS (Associating Liver Partition Portal Vein Ligation for Staged hepatectomy).The recently developed procedure, aiming at removing primarily unresectable liver tumors, has been criticized safety issues with high variations in reported morbidity/mortality rates depending on patient, disease, technical characteristics, center experience. No reference values relevant...
Objective: To test the degree of agreement in selecting therapeutic options for patients suffering from colorectal liver metastasis (CRLM) among surgical experts around globe. Summary/Background: Only few areas medicine have seen so many novel over past decades as tumors. Significant variations may therefore exist regarding choices treatment, even experts, which confuse both medical community and patients. Methods: Ten cases CRLM with different levels complexity were presented to 43 expert...
Postoperative ileus after colorectal surgery is a frequent problem that significantly prolongs hospital stay and increases perioperative costs.The aim was to evaluate the effect of standardized coffee intake on postoperative bowel movement elective laparoscopic resection.This prospective randomized controlled trial conducted between September 2014 December 2016.This study performed in public cantonal Switzerland with accreditation for colon rectum cancer surgery.Patients who underwent were...