A5007639601- Surgical Simulation and Training
- Hepatocellular Carcinoma Treatment and Prognosis
- Anatomy and Medical Technology
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Trauma Management and Diagnosis
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Augmented Reality Applications
- Liver Disease Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Genetic and Kidney Cyst Diseases
- Pancreatic and Hepatic Oncology Research
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Simulation-Based Education in Healthcare
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Innovations in Medical Education
- Renal cell carcinoma treatment
- Extracellular vesicles in disease
- Radiopharmaceutical Chemistry and Applications
Helios Hospital Berlin-Buch
2023-2025
University of Cologne
2015-2024
University Hospital Cologne
2012-2024
LVR-Klinik Köln
2010-2023
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2006-2023
Centrum für Integrierte Onkologie
2020
University Hospital Regensburg
2019
Weatherford College
2018-2019
Pius Hospital Oldenburg
2019
University Hospital Heidelberg
2019
In patients with peritoneal metastasis (PM) from gastric cancer (GC), chemotherapy is the treatment of choice. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal (HIPEC) are still being debated. This randomized, controlled, open-label, multicenter phase III trial (EudraCT 2006-006088-22; ClinicalTrials.gov identifier: NCT02158988) explored impact on overall survival (OS) HIPEC after CRS.
Abstract Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma (HCC). In addition to local tumor destruction, ablation leads abscopal effects in distant lesions most likely mediated by an anti-tumor immune response. Although microwave (MWA) is increasingly substituting other techniques, its systemic immunostimulatory poorly studied. We analyzed tumor-specific responses peripheral blood of HCC patients after thermal with regard T cell and disease outcome....
Abstract Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at advanced stage. The aim study was verify surgical oncological outcome for intrahepatic cholangiocarcinoma (ICC). Methods cohort based on registry with patients from 31 international centers between August 2009 January 2018. Propensity score matched receiving chemotherapy only were selected SEER database as controls survival analysis. Results One hundred two undergoing recruited, 99...
Clinical reasoning is based on the declarative and procedural knowledge of workflows in clinical medicine. Educational approaches such as problem-based learning or mannequin simulators support knowledge. Immersive patient (IPSs) go one step further they allow an illusionary immersion into a synthetic world. Students can freely navigate avatar through three-dimensional environment, interact with virtual surroundings, treat patients. By playful IPS, medical be repetitively trained...
Kidney transplantation is the preferred renal replacement therapy available. Yet, long-term transplant survival unsatisfactory, partially due to insufficient possibilities of longitudinal monitoring and understanding biological processes after transplantation. Small urinary extracellular vesicles (suEVs) - as a non-invasive source information were collected from 22 living donors recipients. Unbiased proteomic analysis revealed temporal patterns suEV protein signature cellular involved in...
Transplant centers commonly evaluate split renal function (SRF) with Tc-99m-mercapto-acetyltriglycin (MAG3) scintigraphy in living kidney donation. Alternatively, the volume can be measured based on predonation CT scans. The aim of this study was to identify most accurate volumetry technique for SRF and prediction postdonation (PDKF).Three techniques (modified ellipsoid [MELV], smart region interest [ROI] volume, cortex [RCV]) were performed 101 donors. Preoperation volumetric determined...
Abstract Purpose Diagnosis with UICC stage IV colorectal cancer often indicates palliative treatment to alleviate symptoms. Data on pain in these patients are still scarce but can help improve symptom management. This study therefore aimed describe patient-reported and quality of life. Methods 147 palliatively treated diagnosed between 2018 2023 completed the EORTC QLQ-C30 QLQ-CR29 before 12 months after initiation within EDIUM study. Descriptive results for life were examined compared...
Immunosuppressive strategies applied in renal transplantation traditionally focus on T cell inhibition. B cells were mainly examined the context of antibody-mediated rejection, whereas impact antibody-independent functions has only recently entered field transplantation. Similar to cells, distinct subsets can enhance or inhibit immune responses. In this study, we prospectively analyzed evolution peripheral blood AB0-compatible (n = 27) and AB0-incompatible 10) transplant recipients....
Background Both laparoscopic surgery and computer games make similar demands on eye-hand coordination visuospatial cognitive ability. A possible connection between both areas could be used for the recruitment training of future residents. Aim The goal this study was to investigate whether gaming skills are associated with better performance in medical students. Methods 135 students (55 males, 80 females) participated an experimental study. Students completed three tasks (rope pass, paper...
To evaluate if "state-of-the-art" 3D- versus 4K-display techniques could influence surgical performance.High quality minimally invasive surgery is challenging. Therefore excellent vision crucial. 3D display technique (3D) and 2D-4K (4K) are designed to facilitate performance, either due spatial resolution or very high (4K).In randomized cross-over trial the performance of medical students (MS), non-board certified surgeons (NBC), board (BC) was compared using 4K at a training Parkour.One...
Laparoscopic deroofing is the standard therapy for simple nonparasitic liver cysts. The operation performed with or without a greater omentum flap sutured into former cyst cavity. aim of this study was to determine whether has influence on recurrence rate cysts during long-term follow-up.From September 1999 November 2009, 23 patients underwent laparoscopic single multiple symptomatic A fill cavity used in 8 patients, whereas 15 carried out such an flap. were identified retrospectively and...
At Eurotransplant (ET), kidneys are transferred to "rescue allocation" (RA), whenever the standard allocation (SA) algorithms Kidney Allocation System (ETKAS) and Senior Program (ESP) fail. We analyzed outcome of RA.Retrospective patient clinical demographic characteristics association analyses were performed with graft outcomes for 2422 recipients a deceased donor renal transplantation (DDRT) after RA versus 25 481 SA from 71 centers across all ET countries 2006 2018.Numbers DDRTs increased...