A5076466984- Adipose Tissue and Metabolism
- Transplantation: Methods and Outcomes
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Renal Transplantation Outcomes and Treatments
- Birth, Development, and Health
- Primate Behavior and Ecology
- Ovarian function and disorders
- Organ and Tissue Transplantation Research
- Viral Infections and Immunology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
- Endometriosis Research and Treatment
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Liver Disease and Transplantation
- Biomedical Text Mining and Ontologies
- Hypothalamic control of reproductive hormones
- Gestational Diabetes Research and Management
- Congenital Diaphragmatic Hernia Studies
University of Wisconsin–Madison
2011-2022
Health Alliance International
2013-2014
Geriatric Research Education and Clinical Center
2005
Institute on Aging
1996-2004
Memorial
2004
Kliniken Essen-Mitte
1997
Hôpital d'Hautepierre
1996
Essen University Hospital
1995
Medizinische Hochschule Hannover
1987-1991
Hochschule Hannover
1990
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness mortality primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study rhesus monkeys aimed at filling this critical gap research. In population macaques maintained the Wisconsin National Primate Research Center, moderate lowered incidence aging-related deaths. At time point reported, 50% control...
Abstract Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact nonhuman primates has been controversial. In late 1980s two parallel studies were initiated to determine effect CR rhesus monkeys. The University Wisconsin study reported a significant positive on survival, National Institute Aging detected no survival effect. Here we present direct comparison longitudinal data from both including bodyweight,...
Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice rats. The value CR as a tool understand human ageing relies on translatability CR’s effects primates. Here we show that significantly improves age-related all-cause survival monkeys long-term ~30% restricted diet since young adulthood. These data contrast with observations 2012 NIA intramural study report,...
A high-quality rhesus macaque genome Genome technology has improved substantially since the first full organismal genomes were generated. Applying new technology, Warren et al. refined of macaque, a model nonhuman primate. Long-read and other recent advances in sequencing applied to generate with far fewer gaps helped refine locations numbers repetitive elements. Furthermore, authors performed resequencing among populations identify genetic variability macaque. Thus, previously incomplete...
Insulin sensitivity and glucose tolerance typically decline during later life. In a multidimensional randomized trial of the effects dietary restriction started in adulthood on processes aging, we are studying insulin glucoregulation longitudinally control (C, n = 15, fed defined diet ad libitum for 6–8 h/day) restricted (R, 30% less than C) monkeys using Modified Minimal Model method. Linear rates change were calculated individual animals through 30 mo treatment compared between groups....
Dietary restriction (DR) retards aging processes and extends maximum life span in rodents simpler animals. We initiated a study 30 adult (8–14 years old) male rhesus monkeys to determine whether or not are retarded by adult-onset DR primate species herein report results from the experiment's first year. Following 3–6 month period when baseline data were obtained, 15 animals assigned control group given free access semipurified diet for 6–8 hours per day. The other fed same but at 70% of...
Activation of the peroxisome proliferator-activated receptor gamma (PPAR-γ) has been proposed as a possible neuroprotective strategy to slow down progression early Parkinson's disease (PD). Here we report preclinical data on use PPAR-γ agonist pioglitazone (Actos®; Takeda Pharmaceuticals Ltd.) in paradigm resembling PD nonhuman primates.Rhesus monkeys that were trained perform battery behavioral tests received single intracarotid arterial injection 20 ml saline containing 3 mg dopaminergic...
A dramatic rise in obesity has occurred among humans within the last several decades. Little is known about whether similar increases have animals inhabiting human-influenced environments. We examined samples collectively consisting of over 20 000 from 24 populations (12 divided separately into males and females) representing eight species living with or around industrialized societies. In all populations, estimated coefficient for trend body weight time was positive (i.e. increasing). The...
Auxiliary liver transplantation (LT) is a special procedure of LT which could be proposed to patients with fulminant hepatic failure (FHF) and has for aim that complete regeneration the native (NL) left in place will allow graft recipient resume normal function after allograft withdrawal. We report 30 cases auxiliary performed FHF 12 European centers. Twenty-five were younger than 50 years. The cause was hepatitis A virus (HAV) 4 patients, B (HBV) 7, paracetamol overdose 5, ecstasy 2,...
This study determined whether timing of prenatal androgen excess resulted in differential impairment insulin-glucose homeostasis adult female rhesus monkeys. Ten monkeys exposed to testosterone propionate starting on gestational day 40 (early treated), 9 females between days 100-115 (late and 15 control were studied. The modified minimal model was used examine various measures derived from an i.v. glucose tolerance test, with regression analysis performed these variables body mass index. In...
The antidiabetic effects of pioglitazone hydrochloride were evaluated in 6 spontaneously obese, insulin-resistant rhesus monkeys. animals studied during six successive 2-wk treatment phases separated by rest periods: two placebo phases; 0.3, 1.0, and 3.0 mg · kg−1 day−1 a final phase. During the second week each phase, serum insulin (immunoreactive [IRI]), plasma glucose, triglyceride (TG) levels measured after an overnight fast standardized meal. Blood pressure was glucose tolerance tests...
Abstract Objective : The aim of this study was to investigate the effects early‐gestational androgen excess on adult body fat distribution in female rhesus monkeys. Research Methods and Procedures Six midreproductive‐aged, monkeys that were exposed started during first one‐third gestation pair‐matched control females by age, weight, mass index. Body composition determined using somatometrics, DXA, computed tomography. Results Total abdominal intra‐abdominal depots are increased prenatal...
Dietary restriction (DR) is currently the only paradigm that has consistently extended maximal life span and reduced onset of age-related chronic diseases in all nonprimate species tested. Although it controversial, some investigators have suggested underlying mechanisms may be mediated by adaptations energy expenditure. We evaluated extent to which DR alters metabolism a unique cohort rhesus monkeys submitted for 11 yr. Total expenditure (doubly labeled water), resting (REE; indirect...
Abstract Normative age‐ and gender‐related changes in body composition, serum lipids, testosterone, insulin‐like growth factor (IGF‐1) were examined the Cayo Santiago free‐ranging rhesus macaques. In both adult males females, weights, crown‐rump lengths, circumference of limbs lowest oldest group (20+ years age) as compared with other age classes. Body fat, reflected subcutaneous fatfold thickness waist/thigh ratios, higher females than males. This gender dimorphism was first detectable...
Extracting DNA from formalin-fixed and paraffin-embedded (FFPE) tissue remains a challenge, despite numerous attempts to develop more effective method. Polymerase chain reaction (PCR) success rates with extracted using current methods remain low. We 140 long-term archived FFPE samples simple but deparaffinization method, removing the wax mineral oil, commercially available extraction kit. quality was subsequently tested in genotyping experiment 14 microsatellite markers. High-quality...
BACKGROUND: Endometriosis occurs in several non‐human primate species that have menstrual cycles. This study investigated the prevalence and familial aggregation of endometriosis one those species, rhesus macaque. METHODS: Between 1978 2001, 142 animals with were identified from necropsy surgical records through use magnetic resonance imaging (MRI) at Wisconsin National Primate Research Center, Madison, USA. All cases used to build large multigenerational pedigree nine nuclear families...
Animals with lateral hypothalamic lesions lost significantly more weight in the 18 h following this lesion than did sham-operated animals or rats cerebral cortical deprived of food for same time period. In acutely fasted turnover norepinephrine interscapular brown adipose tissue, heart, and pancreas was slowed but rates were three- to ninefold faster all three organs. Exposure cold (4 degrees C) increased rats, not further increase rate hypothalamic-lesioned rats. Rats cortex responded a...