A5037061653- HIV Research and Treatment
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Herpesvirus Infections and Treatments
- Open Source Software Innovations
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
- Primate Behavior and Ecology
- Cytomegalovirus and herpesvirus research
- Cardiomyopathy and Myosin Studies
- Software Engineering Research
- Estrogen and related hormone effects
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Cardiovascular Disease and Adiposity
- Virology and Viral Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Knowledge Management and Sharing
- Virus-based gene therapy research
- Retinal Diseases and Treatments
- SARS-CoV-2 detection and testing
- Retinal Imaging and Analysis
- Psychology of Moral and Emotional Judgment
- Cardiovascular Effects of Exercise
- Academic integrity and plagiarism
Oregon National Primate Research Center
2020-2025
University of California, Davis
2006-2024
University of Louisville
2018
Veterinary Medical Teaching Hospital
2016
Duquesne University
2006-2013
Carnegie Mellon University
2006
University of Kentucky
2005
Icahn School of Medicine at Mount Sinai
1997-2003
The University of Texas Medical Branch at Galveston
2000
University of California, San Diego
1999
Understanding what motivates participation is a central theme in the research on open source software (OSS) development. Our study contributes by revealing how different motivations of OSS developers are interrelated, these influence leading to performance, and past performance influences subsequent motivations. Drawing theories intrinsic extrinsic motivation, we develop theoretical model relating motivations, participation, developers. We evaluate our using survey archival data collected...
Prior research has shown that customer-reported software faults are often the result of violated dependencies not recognized by developers implementing software. Many types and corresponding measures have been proposed to help address this problem. The objective is compare relative performance several these dependency as they relate defects. Our analysis based on data collected from two projects independent companies. Combined, our set encompasses eight years development activity involving...
Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk death HCM has been reported be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities arrhythmias as well heart rate variability (HRV) an assessment autonomic balance. Sudden in association naturally-occurring left ventricular hypertrophy (LVH) a colony rhesus macaques under investigation potential...
A high-quality rhesus macaque genome Genome technology has improved substantially since the first full organismal genomes were generated. Applying new technology, Warren et al. refined of macaque, a model nonhuman primate. Long-read and other recent advances in sequencing applied to generate with far fewer gaps helped refine locations numbers repetitive elements. Furthermore, authors performed resequencing among populations identify genetic variability macaque. Thus, previously incomplete...
Among the identified risks and benefits of hormone-replacement therapy, effects treatment on cognitive function in postmenopausal women have proved difficult to define. Here we conducted a controlled, prospective analysis nonhuman primate model test whether surgical menopause estrogen replacement influence outcome normal aging. Sixteen aged rhesus monkeys were ovariectomized, throughout course subsequent neuropsychological assessment, half received regimen low-dose, cyclic estradiol...
Long-term cyclic treatment with 17beta-estradiol reverses age-related impairment in ovariectomized rhesus monkeys on a test of cognitive function mediated by the prefrontal cortex (PFC). Here, we examined potential neurobiological substrates this effect using intracellular loading and morphometric analyses to possibility that benefits hormone are associated structural plasticity layer III pyramidal cells PFC area 46. 17beta-Estradiol did not affect several parameters such as total dendritic...
The effects of normal aging on the primate brain are incompletely understood. Although both human and nonhuman primates demonstrate clear functional declines in selective attention, “executive” functions, some components declarative memory with aging, most studies have failed to extensive neuronal atrophy or loss as a substrate for these degenerative changes primates. In particular, age-related memory-related regions such hippocampus entorhinal cortex has not been found. However, it is...
Abstract It is well documented that estrogen increases dendritic spine density in CA1 pyramidal cells of young female rats. However, this effect attenuated aged We report here a quantitative analysis effects on hippocampal number as visualized with antispinophilin (6–8 years old) and (19–23 rhesus monkeys, species pattern endocrine senescence comparable to humans. Monkeys were ovariectomized administered either vehicle or estradiol cypionate 3 months postovariectomy, followed by an...
Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 10,000 individuals, respectively. A major limitation to the development effective therapies is lack availability animal models that fully replicate human condition. Particularly for disorders, rodent, canine, feline no true macula have substantive limitations. By contrast, cone-rich nonhuman primate (NHP) closely mirrors retina....
The objective of this study was to assess ovarian activity in a cohort aged female rhesus macaques. Menstrual records for 26 macaques ages 20-29 yr were evaluated over 1-yr period, and daily urinary estrone conjugate (E1C) pregnanediol-3-glucuronide (Hygeia [Hy]-PdG) levels determined 12 wk. Each animal categorized as either pre-, peri-, or postmenopausal based on menstrual hormonal data. Eleven animals (mean age 22.5 yr) premenopausal, thirteen 24 perimenopausal, two 29.5 postmenopausal....
Abstract The corticospinal projection is considered to influence fine motor function through nearly exclusively contralateral projections from the cortex in primates. However, unilateral lesions this system various species are frequently followed by significant functional improvement, raising possibility that bilateral of pathway may exist or emerge after injury. To examine detailed anatomy and neurons rhesus monkeys (n = 4), we injected high‐resolution anterograde tracer biotinylated...
Mechanisms of cognitive decline with aging remain primarily unknown. We determined whether localized cell loss occurred in brain regions associated age-related primates. On a task requiring the prefrontal cortex, aged monkeys were impaired maintaining representations working memory. Stereological quantification area 8A, region memory, demonstrated significant 32 ± 11% reduction number Nissl-stained neurons compared young monkeys. Furthermore, immunolabeled cholinergic projecting to this...
Open source software (OSS) communities live and die with the continuous contributions of programmers who often participate without direct remuneration. An intriguing question is whether such sustained participation in OSS projects yields economic benefits to participants. Moreover, as participants engage projects, they take on different roles activities community. This raises additional questions forms are associated rewards and, if so, which contexts. In this paper, we draw upon theories...
SPATIAL information processing was examined in a non-human primate model of cognitive aging, using procedures formally similar to tasks designed for rats. The test apparatus large open field containing eight reward locations. Monkeys rapidly learned visit each location once per trial, and probe manipulations confirmed that young animals navigated according the distribution cues surrounding maze. In contrast, aged monkeys solved task response sequencing strategy, independent extramaze spatial...
Past dogma asserted that extensive loss of cortical neurons accompanies normal aging. However, recent stereologic studies in humans, monkeys, and rodents have found little evidence age-related neuronal several regions, including the neocortex hippocampus. Yet to date, a complete investigation or size change has not been undertaken entorhinal cortex, retrohippocampal structure essential for learning memory. The aged rhesus macaque monkey (Macaca mulatta), species develops β-amyloid plaques...
THE present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on delayed response (DR) task known to be sensitive aging, reproductive status was evaluated according menstrual cyclicity urinary hormone profiles. Peri-/postmenopausal exhibited significant DR impairments relative either agematched premenopausal females, or young control...
ABSTRACT Tenofovir gel (1%) is being developed as a microbicide for the prevention of human immunodeficiency virus (HIV) infection and has been shown to reduce transmission women by 39%. The also prevents in macaques when applied intravaginally or intrarectally prior challenge with simian-human (SHIV), but very little pharmacokinetic information available help extrapolate data humans thus inform future development activities. We have determined pharmacokinetics tenofovir following...
Journal Article Epidemiology of Cercopithecine Herpesvirus 1 (B Virus) Infection and Shedding in a Large Breeding Cohort Rhesus Macaques Get access Benjamin J. Weigler, Weigler Reprints or correspondence (present address): Dr. Dept. Companion Animal Special Species Medicine, College Veterinary 4700 Hillsborough St., Raleigh, NC 27606. Search for other works by this author on: Oxford Academic PubMed Google Scholar David W. Hird, Hird Julia K. Hilliard, Hilliard Nicholas Lerche, Lerche Jeffrey...