A5075915892- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Lung Cancer Research Studies
- Gastrointestinal disorders and treatments
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
University of Colorado Anschutz Medical Campus
2016-2025
University of Colorado Denver
2016-2025
University of Colorado Cancer Center
2019-2025
University of Colorado Hospital
2015-2024
Johns Hopkins University
2009-2023
Sidney Kimmel Cancer Center
2005-2023
University of Colorado System
2023
Twitter (United States)
2022
Oregon Health & Science University
2021
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021
The lack of consensus on how to define and grade adverse postoperative events has greatly hampered the evaluation surgical procedures. A new classification complications, initiated in 1992, was updated 5 years ago. It is based type therapy needed correct complication. principle be simple, reproducible, flexible, applicable irrespective cultural background. aim current study critically evaluate this from perspective its use literature, by assessing interobserver variability grading complex...
Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia. To explore the genetic basis PanNETs, we determined exomic sequences 10 nonfamilial PanNETs and then screened most commonly mutated genes in 58 additional PanNETs. The frequently specify proteins implicated chromatin remodeling: 44% had somatic inactivating mutations MEN1, which encodes menin, component histone methyltransferase complex, 43% encoding either two subunits...
To examine trends in outcomes of patients undergoing resection at a single tertiary care referral center over 16-year period.Hepatic is considered the treatment choice selected with colorectal metastasis confined to liver. Although variety retrospective studies have demonstrated improvements short-term recent years, changes long-term survival time are less well-established.Data from 226 consecutive potentially curative liver for metastases between 1984 and 1999 were analyzed. Actuarial rates...
To assess long-term survival and prognostic factors in a large series of patients with bile duct cancer.The incidence cancer is low but increasing. Determinants vary the literature, due to lack sufficient numbers most series.We studied 564 consecutive operated upon between 1973 2004. Patients were divided into intrahepatic, perihilar, distal groups. Principle outcome measures complications, 30-day mortality, survival.Of patients, 44 (8%) had 281 (50%) 239 (42%) tumors. Approximately half...
A mutation in the gene GNAS serves as a marker for pancreatic cysts that can progress to become invasive adenocarcinomas, guiding therapy.
In Brief Objective(s): To investigate rates and patterns of recurrence in patients following curative intent surgery for colorectal liver metastasis. Background: Outcomes surgical management metastasis have largely focused on overall survival. Contemporary data are limited. Methods: One thousand six hundred sixty-nine treated with (resection ± radiofrequency ablation [RFA]) between 1982 2008 were identified from an international multi-institutional database. Clinicopathologic data, patterns,...
Purpose To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact lymph node (LN) assessment on survival. Patients Methods From an international multi-institutional database, 449 patients who underwent surgery for ICC between 1973 2010 were identified. Clinical pathologic data evaluated using uni- multivariate analyses. Results Median tumor size was 6.5 cm. Most had a solitary (73%) no vascular invasion (69%)....
More than 2% of adults harbor a pancreatic cyst, subset which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes neoplastic cysts pancreas, we determined exomic sequences DNA from epithelium eight surgically resected each major cyst types: serous cystadenomas (SCAs), intraductal papillary mucinous neoplasms (IPMNs), cystic (MCNs), and solid pseudopapillary (SPNs). SPNs are low-grade malignancies, IPMNs MCNs, but not SCAs, have capacity progress cancer....
Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare malignant neoplasms with a poor prognosis. The aim this study was to determine clinicopathologic and genetic features poorly NECs compare them other types pancreatic neoplasms. We investigated alterations KRAS, CDKN2A/p16, TP53, SMAD4/DPC4, DAXX, ATRX, PTEN, Bcl2, RB1 by immunohistochemistry and/or targeted exomic sequencing in surgically resected specimens 9 small cell NECs, 10 large 11 well-differentiated...
Pancreatic cancers are the fourth most-common cause of cancer-related deaths in Western world, with >200,000 cases reported 2010. Although up to 10% these occur familial patterns, hereditary basis for predisposition vast majority affected families is unknown. We used next-generation sequencing, including whole-genome and whole-exome analyses, identified heterozygous, constitutional, ataxia telangiectasia mutated (ATM) gene mutations 2 kindreds pancreatic cancer. Mutations segregated disease...
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance conventional therapies. Published studies show that the PDA tumor microenvironment is predominantly infiltrated with immune suppressive cells signals if altered, would allow effective immunotherapy. However, single-agent checkpoint inhibitors including agents alter in other human cancers such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1), its ligand PD-L1, have failed...
To examine the efficacy of adjuvant chemoradiotherapy after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC) in patients undergoing resection at Johns Hopkins Hospital (JHH; Baltimore, MD).Between August 30, 1993, and February 28, 2005, a total 908 underwent PD PC JHH. A prospective database was reviewed to determine which received fluorouracil (FU) -based CRT. Excluded had metastatic disease, died 60 or fewer days PD, preoperative therapy, an experimental vaccine,...