A5023965369- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- IgG4-Related and Inflammatory Diseases
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Diagnosis and Treatment
- Kruppel-like factors research
- Sarcoma Diagnosis and Treatment
- Pancreatic function and diabetes
- Colorectal Cancer Treatments and Studies
Koç University
2018-2025
Marmara University
2017-2022
University of Alabama at Birmingham
2022
University of Michigan–Ann Arbor
2003-2022
Emory University
2010-2020
Medical College of Wisconsin
2017-2020
Winship Cancer Institute
2009-2018
Emory University Hospital
2007-2017
University of Ulsan
2015-2017
Shinshu University
2017
Abstract Emerging evidence has suggested that the capability of a tumor to grow and propagate is dependent on small subset cells within tumor, termed cancer stem cells. Although data have been provided support this theory in human blood, brain, breast cancers, identity pancreatic not determined. Using xenograft model which primary adenocarcinomas were grown immunocompromised mice, we identified highly tumorigenic subpopulation expressing cell surface markers CD44, CD24, epithelial-specific...
Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been subject of numerous morphologic, clinical, genetic studies; however, a standard nomenclature diagnostic criteria for classifying these lesion not established. To evaluate uniformity existing systems grading duct pancreas, 35 microscopic slides with representative were sent to eight expert pathologists from United States, Canada, Europe. Kappa values interobserver agreement could be calculated...
International experts met to discuss recent advances and revise the 2004 recommendations for assessing reporting precursor lesions invasive carcinomas of pancreas, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), cystic neoplasm, other lesions. Consensus include following: (1) To improve concordance align with practical consequences, a 2-tiered system (low vs. high grade) is proposed all lesions, provision that current PanIN-2 neoplasms...
Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRASG12D, that result a dominant-active form of GTPase. However, how promote pancreatic carcinogenesis not fully understood, and whether oncogenic required for maintenance has been established. To address these questions, we generated two mouse models tumorigenesis: mice transgenic inducible KrasG12D, which allows inducible, pancreas-specific, reversible expression or without inactivation one...
More than 2% of adults harbor a pancreatic cyst, subset which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes neoplastic cysts pancreas, we determined exomic sequences DNA from epithelium eight surgically resected each major cyst types: serous cystadenomas (SCAs), intraductal papillary mucinous neoplasms (IPMNs), cystic (MCNs), and solid pseudopapillary (SPNs). SPNs are low-grade malignancies, IPMNs MCNs, but not SCAs, have capacity progress cancer....
Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas are intraductal tumors with variable amounts papilla formation, mucin production, and cytoarchitectural atypia. Associated invasive carcinomas, reported to occur in up 30% patients, often mucinous clinically indolent.The clinical pathologic features 28 IPMNs resected at Memorial Sloan-Kettering Cancer Center between 1983 1997 were reviewed.There 16 females 12 males a mean age 68 years (range, 44-79 years) tumor size 4.5 cm...
Although general characteristics of intraductal papillary mucinous neoplasms (IPMNs) and their delineation from other pancreatic tumors have been well established, several issues regarding biology management remain unresolved. It has noted briefly by us authors that there are different types papillae in IPMNs; however, frequency, biologic significance, clinical relevance unknown. In this study, the association patterns with clinical, pathologic, parameters was studied 74 IPMNs, expression...
The 2010 World Health Organization (WHO) classification recommends that pancreatic neuroendocrine tumors (PanNETs) be graded on the basis of mitotic rate and Ki67 index, with grade 2 (G2) PanNETs defined as having a to 20 figures/10 high-power fields or index 3% 20%. Grade 3 (G3) carcinoma (NEC) is >20 >20%. However, some show discordance between usually in G3 range but suggesting G2, prompting us examine clinical significance large series clinically well-characterized G2 PanNETs. Mitotic...
Abstract Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These a spectrum pathologic changes; however, until now, there has no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University Pennsylvania, was held from December 1 3, 2004 with goal establishing an internationally accepted for pathology neoplasia. in 12 existing reviewed at this standardized...
Epithelial neuroendocrine tumors (NETs) have been the subject of much debate regarding their optimal classification. Although multiple systems nomenclature, grading, and staging proposed, none has achieved universal acceptance. To help define underlying common features these classification to identify minimal pathology data that should be reported ensure consistent clinical management reproducibility from therapeutic trials, a multidisciplinary team physicians interested in NETs was...
Abstract Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing. overexpressed in many cancers and correlates with poor prognosis both breast prostate cancers. However, status H3K27 methylation its clinical implication cancer patients have not been reported. We thus examined trimethylation (H3K27me3) immunohistochemistry association variables breast, ovarian, pancreatic found H3K27me3 expression was significantly lower ovarian...
There are no established guidelines for pathologic diagnosis/reporting of intraductal papillary mucinous neoplasms (IPMNs).
In the pancreas, poorly differentiated neuroendocrine carcinomas include small cell carcinoma and large are rare; data regarding their pathologic clinical features very limited.