Amanda Clarke
A5033923938- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Musculoskeletal pain and rehabilitation
- Aging and Gerontology Research
- Mental Health and Patient Involvement
- Pain Management and Opioid Use
- Empathy and Medical Education
- Migration, Aging, and Tourism Studies
- Cancer Genomics and Diagnostics
- Healthcare innovation and challenges
- Intergenerational Family Dynamics and Caregiving
- Grief, Bereavement, and Mental Health
- Obesity, Physical Activity, Diet
- Pain Management and Placebo Effect
- Technology Use by Older Adults
- Interprofessional Education and Collaboration
- Obesity and Health Practices
- Stroke Rehabilitation and Recovery
- Family and Patient Care in Intensive Care Units
- Patient-Provider Communication in Healthcare
- Prostate Cancer Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer survivorship and care
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nursing education and management
Northumbria University
2014-2024
Maidstone Hospital
2017-2024
University of Newcastle Australia
2023
Newcastle University
2023
National Institutes of Health
2014-2015
University of British Columbia
2014
Teesside University
2013
University of Aberdeen
2009-2012
Centre of Advanced Studies
2011
Mount Vernon Hospital
2011
Gastric cancer is a leading cause of deaths, but analysis its molecular and clinical characteristics has been complicated by histological aetiological heterogeneity. Here we describe comprehensive evaluation 295 primary gastric adenocarcinomas as part The Cancer Genome Atlas (TCGA) project. We propose classification dividing into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, amplification JAK2, CD274 (also...
<h2>Summary</h2> Papillary thyroid carcinoma (PTC) is the most common type of cancer. Here, we describe genomic landscape 496 PTCs. We observed a low frequency somatic alterations (relative to other carcinomas) and extended set known PTC driver include <i>EIF1AX</i>, <i>PPM1D</i>, <i>CHEK2</i> diverse gene fusions. These discoveries reduced fraction cases with unknown oncogenic from 25% 3.5%. Combined analyses variants, expression, methylation demonstrated that different groups lead...
Liver cancer has the second highest worldwide mortality rate and limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing DNA copy number analyses, we 196 HCC methylation, RNA, miRNA, proteomic expression also. mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, SMARCA4. Significant alterations or downregulation hypermethylation in genes likely to result metabolic reprogramming (ALB, APOB, CPS1) were...
Summary • Recent policy statements have stressed the need for fundamental changes to NHS, especially hospital care of older people. Person‐centred underpins such changes. If practitioners are deliver person‐centred care, then they learn more about patient as an individual. One way that this might be achieved is through biographical approaches. This paper describes findings a developmental study undertaken over 6‐month period investigate introduction approach on unit in NHS hospital. It...
This paper reports a literature review on the topic of ethical issues in in-depth interviews. The returned three types article: general discussion, particular studies, and studies interview-based research ethics. Whilst many discussed these articles are generic to ethics, such as confidentiality, they often had manifestations this type research. For example, privacy was significant problem interviews sometimes probe unexpected areas. similar reasons, it is difficult give full information...
Aims and objectives. This paper aims to: • Consider the major challenges to involving people with dementia in qualitative research. Critique a process consent framework. Demonstrate need for nurses researchers explore these issues research practice dementia. impact of Mental Capacity Act 2005 on To achieve its aims, authors will draw current literature use examples which explores life story work by taking approach. Background. There is acceptance that should consider ways actively as...
ABSTRACT ‘Active ageing’ is a key concept in current policy and research on ageing yet under-analysed or interpreted largely within an economic framework. This paper explores active the broader context of older people's lives. Drawing series biographical interviews with 23 people aged 60–96 years, discussion focuses theme future hopes concerns. Exhortations for ‘active may be challenged by lifelong unwillingness to look forward plan ahead. Nevertheless, findings show that fears limited...
Person-centred care has been linked with quality of but difficulties remain in person-centred being implemented practice. This study explores the use life story work to enhance people dementia.The investigates how is: understood and developed practice; experienced by all participants affects delivery outcomes care.The experience older dementia, family carers staff using was explored within an NHS Health Social Care Trust. A multiple case design adopted a constructivist approach....
Young people (18-25 years) during the adolescence/adulthood transition are vulnerable to weight gain and notoriously hard reach. Despite increased levels of overweight/obesity in this age group, physical activity behaviour, a major contributor obesity, is poorly understood. The purpose study was explore (PA) behaviour among 18-25 year olds with influential factors including attitudes, motivators barriers.An explanatory mixed method design, based on health Behaviour Change Theories used....
Background: Young people (18–25 years) during the adolescence/adulthood transition are vulnerable to weight gain and notoriously hard reach. Despite increased levels of overweight/obesity in this age group, diet behaviour, a major contributor obesity, is poorly understood. The purpose study was explore behaviour among 18–25 year olds with influential factors including attitudes, motivators barriers. Methods: An explanatory mixed method design, based on health Behaviour Change Theories used....
To present findings from the first stage of an exploratory study investigating nurses' understanding and facilitation person-centred care within acute medical ward.The term 'person-centred care' is used frequently in healthcare policy practice. However, ways which concept translated into everyday nursing continue to a challenge. Person-centred has been explored extensively older people, people with dementia learning disability. Little empirical research conducted ward settings. This starts...
Background Over 50% of community-dwelling older adults experience chronic pain, which threatens their quality life. Of importance to pain management is people's interaction with health professionals that, if unsatisfactory, may impair the outcome. Aims To add limited research specific people living in community, we explored how they perceive experiences interacting professionals, seeking factors that might optimise these interactions. Methods Purposive sampling was used recruit men and women...
Introduction Life story work is increasingly being used with people dementia; this offers a critical appraisal of some challenges that may be faced in practice. Design and methods An in-depth case study analysis was undertaken to understand the experiences dementia, family carers care staff using life an NHS Mental Health Social Care Trust. Data collection included semi-structured interviews, observation, conversations field notes. Findings Private memories were sometimes recalled by person...
To explore compassion from the perceptions of individuals with personal experience nursing care.Although is considered integral to professional nursing, increasing reports care experiences illustrating a lack have challenged this. Despite political and guidance reaffirm as an underpinning philosophy contemporary practice, this provides limited insight into what may involve. Contemporary evidence inform understanding predominately arises perspective. This knowledge gap supported rationale...
This paper provides a concept analysis of respite care for frail older people and their family carers. The authors re-examine the broader conceptualization delineated by Nolan & Grant, namely, users' needs information, education support about care, based on review recent literature user focus group study. work was undertaken Sheffield arm ACTION Project research team. is 36-month project (1997-1999), involving Northern Ireland, Republic Portugal, Sweden England largest nurse-led to have...
Aim: To develop and evaluate an education programme to help older people find out about treatment care choices at the end of life. Design: An action research approach was used booklet end-of-life care. A qualitative evaluation ran alongside project. It comprised a combination methods, including face-to-face telephone interviews questionnaires with those who took part in small group discussions. Sample: The team consisted five academic researchers eight recruited from voluntary groups...
Over 50% of older adults experience chronic pain. Poorly managed pain threatens independent functioning, limits social activities and detrimentally affects emotional wellbeing. Yet, is not fully understood from adults’ perspectives; subsequently, management in later life necessarily based on their priorities or needs. This paper reports a qualitative exploration accounts living with pain, focusing how they describe view to informing approaches its assessment. Cognitively intact men women...
Background Health professionals continue to seek ways promote positive communication and self‐worth when supporting people living with dementia. The value of creative writing techniques as part reflective practice in nursing caring for older dementia needs further exploration. Aim To introduce health dementia‐related practice. Method A local experienced author facilitated workshops nine preregistration students (general mental health), one family carer five care working Findings student...