Candace Carter
A5047937578- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- RNA Research and Splicing
- Nitrogen and Sulfur Effects on Brassica
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Chromatin Remodeling and Cancer
- Bladder and Urothelial Cancer Treatments
- Glioma Diagnosis and Treatment
- Mining and Resource Management
- Genomic variations and chromosomal abnormalities
- Single-cell and spatial transcriptomics
- DNA Repair Mechanisms
- Ancient Mediterranean Archaeology and History
Cooperative Trials Group for Neuro-Oncology
2017-2022
National Health and Medical Research Council
2017-2022
Hudson Institute
2022
Colorado State University
2021-2022
Cargill (United States)
2022
The University of Sydney
2007-2021
New South Wales Department of Health
2017-2021
Duquesne University
2020-2021
National Institute on Deafness and Other Communication Disorders
2018
University of British Columbia
2012-2017
We analysed primary breast cancers by genomic DNA copy number arrays, methylation, exome sequencing, messenger RNA microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes demonstrated the existence of four main cancer classes when combining data from five platforms, each which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA...
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- sequencing-based technologies. Uterine serous tumours ∼25% high-grade endometrioid had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, frequent TP53 mutations. Most alterations or mutations, but mutations in PTEN, CTNNB1, PIK3CA, ARID1A KRAS novel the SWI/SNF chromatin remodelling complex gene ARID5B....
Each year funding agencies and academic institutions spend millions of dollars euros on biobanking. All providers assume that after initial investments biobanks should be able to operate sustainably. However the topic sustainability is challenging for discipline biobanking several major reasons: diversity in landscape, different purposes biobanks, fact are dissimilar other research infrastructures absence universally understood or applicable value metrics funders stakeholders. In this...
Biobanks face increasing demands for research materials of consistent quality, which can be used in collaborative studies. Several countries and some international agencies have made formal efforts to standardize biobank operations outputs. These include the establishment best practice guidelines collection management, certification programs. Such programs increase biobanks' opportunities participation high impact funding. However, they also impose economic time costs, may burden biobanks....
Vanilloids including capsaicin and resiniferatoxin (RTX) have been identified as potential novel anti-inflammatory analgesic compounds. We previously shown that systemic administration to neonatal rats evokes profound long-term alterations in transient receptor vanilloid 1 (TRPV1)- neurokinin (NK<sub>1</sub>) receptor-mediated respiratory responses the commissural nucleus of solitary tract (cNTS). Whether this effect is unique developmentally immature animals unknown. Therefore,...
Biobanks are resources that facilitate research. Many biobanks exist around the world, but most tend to focus on a specific disease or research area. BC Children's Hospital and Women's located same campus (Oak Street Campus) in Vancouver, BC, Canada. A campus-wide biobank has been established site of these two hospitals collect specimens annotated data from children women seeking medical care at either hospitals. Such an initiative requires careful planning consideration many factors such as...
Human health biobanks are forms of research infrastructure that supply biospecimens and associated data to researchers, therefore juxtapose the activities clinical care biomedical research. The discipline biobanking has existed for over 20 years is supported by several international professional societies dedicated academic journals. However, despite both rising demand human biospecimens, growth as an discipline, many individual continue experience sustainability challenges. This commentary...
Glioblastoma (GBM) is the most common malignant primary central nervous system cancer in adults. The objective of Multi-Arm GlioblastoMa Australasia (MAGMA) trial to test hypotheses real world setting improve survival people with GBM. Initial experimental arms are evaluating effectiveness interventions newly diagnosed GBM (ndGBM). This study will compare maximal surgical resection followed by chemoradiotherapy plus adjuvant chemotherapy for 6 months addition (1) 'neoadjuvant' beginning as...
The neuro-oncology community in Australia is well positioned to collaborate internationally, with a motivated trials group, strong regulatory bodies and an attractive fiscal environment. We sought identify gaps the Australian clinical landscape describe strategies increase international trial access Australia.We searched registries active adult primary brain cancer trials. compared participation rate phase of these between tumour types countries. A survey was distributed Cooperative Trials...
The small marble group in the collection of antiquities New York University, published by Karl Lehmann as "The Girl Beneath Apple Tree" AJA 49 (1945) 430-33, can now be reinterpreted. A comparison with a coin from Temenothyrae (Phrygia) time Valerian allows us to reconstruct representation Herakles Garden Hesperides, and restore figure on right side base, empty. statuette is thus "promoted" genre scene mythological representation. Ganymede Eagle excavated at Carthage 1977, recently Elaine...