A5056466058- Metal complexes synthesis and properties
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Ferrocene Chemistry and Applications
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Endometrial and Cervical Cancer Treatments
- PARP inhibition in cancer therapy
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Intraperitoneal and Appendiceal Malignancies
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Clinical practice guidelines implementation
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cancer therapeutics and mechanisms
- Drug Transport and Resistance Mechanisms
- DNA and Nucleic Acid Chemistry
- Chronic Myeloid Leukemia Treatments
- Estrogen and related hormone effects
Royal Prince Alfred Hospital
2013-2024
Concord Repatriation General Hospital
2015-2024
Concord Hospital
2010-2024
Fox Chase Cancer Center
2024
Cancer Care Services
2024
Sydney Adventist Hospital
2024
South Eastern Sydney Local Health District
2024
Tamworth Hospital
2024
Nepean Hospital
2024
Naval Medical Center Portsmouth
2024
Angiogenesis plays a role in the biology of ovarian cancer. We examined effect bevacizumab, vascular endothelial growth factor inhibitor, on survival women with this disease.
The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer the addition of bevacizumab to standard chemotherapy, greatest effect patients at high risk disease progression. We report final overall results trial.ICON7 was an international, phase 3, open-label, randomised undertaken 263 centres 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult newly diagnosed that either high-risk early-stage (International Federation...
Abstract Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis provides new insight into PARPi response in preclinical models and cancer patients. The 12 HGSOC patient-derived xenografts (PDX) the rucaparib was assessed, variable dose-dependent responses observed chemo-naive BRCA1/2 -mutated PDX, no PDX...
Cognitive dysfunction is reported in people with cancer. Therefore, we evaluated longitudinal changes cognitive function and underlying mechanisms colorectal cancer (CRC) healthy controls (HCs).Participants completed assessments questionnaires reporting symptoms, fatigue, quality of life, anxiety/depression at baseline (before chemotherapy, if given) 6, 12, 24 months. Blood tests included cytokines, clotting factors, apolipoprotein E genotype, sex hormones. Primary end point was overall...
In this study, we assessed the activity of durvalumab, an antibody to programmed death ligand-1, in two cohorts women with advanced endometrial cancers (AEC)-mismatch repair proficient (pMMR) and mismatch deficient (dMMR).A multicenter phase study was performed AEC pMMR tumor progressing after one three lines chemotherapy dMMR zero chemotherapy. Mismatch status based on immunohistochemistry expression. All received durvalumab 1500 mg given every 4 weeks until progression or unacceptable...
BackgroundSubstantial numbers of cancer patients use complementary medicine therapies, even without a supportive evidence base. This study aimed to evaluate in randomized controlled trial, the Medical Qigong (MQ) compared with usual care improve quality life (QOL) patients.Patients and methodsOne hundred sixty-two range cancers were recruited. QOL fatigue measured by Functional Assessment Cancer Therapy—General Therapy—Fatigue, respectively, mood status Profile Mood State. The inflammatory...
Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmacokinetics and anti-tumour activity, as well assess how food affects bioavailability. To determine dose-limiting toxicities (DLT) maximum tolerated dose (MTD), temozolomide 100-250 mg...
Abstract: The purpose of this study was to evaluate novel inflammatory and nutritional prognostic factors in patients with advanced colorectal cancer (ACRC). All ACRC attending the clinic for palliative treatment were eligible study. Demographics, including performance status (PS), C-reactive protein (CRP), albumin (Alb), Glasgow score (GPS), weight, weight history, body mass index (BMI), using patient-generated subjective global assessment (PGSGA), collected correlated survival. At a median...
Abstract: The evaluation of nutritional status in cancer patients is often neglected spite the fact that poor may adversely affect prognosis and treatment tolerance. In day-to-day oncology practice, a sensitive but simply applied assessment tool needed to identify at-risk patients. Several tools exist; however, none has been universally accepted. aim this study was compare two potential tools, Mini-Nutritional Assessment (MNA) scored Patient Generated Subjective Global (PGSGA). MNA more does...
Here we describe the use of X-ray absorption near edge spectroscopy (XANES) to provide information about relative proportions platinum(II) and platinum(IV) complexes by analyzing XANES height. The intracellular reduction in cancer cells has been observed directly, proportion after 2 h was found correlate with potentials complexes.
Decision making in advanced cancer is increasingly complex. We developed a decision aid (DA) for patients with colorectal who are considering first-line chemotherapy and reviewing treatment options, prognostic information, toxicities. examined its impact on patient understanding, decisions, decisional conflict, making, consultation satisfaction, anxiety, quality of life by using randomized trial design.In all, 207 were metastatic disease randomly assigned to receive standard medical oncology...
Abstract Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, subset of patients has an unexpected dramatic and durable response to treatment. We sought identify clinical, pathological, molecular determinants exceptional survival in women high-grade serous (HGSC), disease associated the majority deaths. Experimental Design: evaluated histories 2,283 and, after applying stringent clinical pathological selection criteria, identified 96 HGSC that represented...
We modified and evaluated an advance care planning (ACP) intervention, which had been shown to improve compliance with patient's end of life (EoL) wishes, in a different patient population. Patients incurable cancer, Family Member (FM), were randomised one-to-one usual or plus ACP between April 2014 January 2017. Oncologists participants non-blinded. was based on the Respecting Patient Choices model, offer provide individualised ranges for typical, best-case worst-case scenarios survival...