A5089629100- Childhood Cancer Survivors' Quality of Life
- Astronomy and Astrophysical Research
- Galaxies: Formation, Evolution, Phenomena
- Cancer survivorship and care
- Testicular diseases and treatments
- Adolescent and Pediatric Healthcare
- Astrophysics and Star Formation Studies
- Acute Lymphoblastic Leukemia research
- Stellar, planetary, and galactic studies
- Family Support in Illness
- Sarcoma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Gamma-ray bursts and supernovae
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Patient-Provider Communication in Healthcare
- Lymphoma Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Global Cancer Incidence and Screening
- Astronomical Observations and Instrumentation
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Gastrointestinal Tumor Research and Treatment
Klinikum Oldenburg
2025
University of Leeds
2016-2025
Leeds Teaching Hospitals NHS Trust
2011-2025
University of Arizona
2012-2024
St James's University Hospital
2014-2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2024
University College London
2024
National Cancer Research Institute
2021
Schulthess-Klinik
2021
Astronomy and Space
2019
Angiogenesis plays a role in the biology of ovarian cancer. We examined effect bevacizumab, vascular endothelial growth factor inhibitor, on survival women with this disease.
The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer the addition of bevacizumab to standard chemotherapy, greatest effect patients at high risk disease progression. We report final overall results trial.ICON7 was an international, phase 3, open-label, randomised undertaken 263 centres 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult newly diagnosed that either high-risk early-stage (International Federation...
PURPOSE: We aimed to estimate the prevalence and types of anxiety disorders diagnosed according standardized criteria in cancer patients, compare screening tools detecting them, examine their demographic, oncologic, psychosocial associations. METHODS: In this cross-sectional observational study 178 subjects with lymphoma, renal cell carcinoma, malignant melanoma, or plasma dyscrasia, we related responses questionnaires (administered by computer touch-screen) measuring psychological symptoms,...
BackgroundAngiogenesis is a validated clinical target in advanced epithelial ovarian cancer. Cediranib an oral antiangiogenic vascular endothelial growth factor receptor 1–3 inhibitor that has shown antitumour activity recurrent We assessed efficacy and safety of cediranib combination with platinum-based chemotherapy as continued maintenance treatment patients first relapse platinum-sensitive cancer.MethodsIn this randomised, three-arm, double-blind, placebo-controlled phase 3 trial, we...
The classification of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has been a major advance in management germ-cell tumors, but relies on data only 660 patients with seminoma treated between 1975 and 1990. We re-evaluated this database from large international consortium.Data 2,451 men metastatic cisplatin- etoposide-based first-line chemotherapy 1990 2013 were collected 30 institutions or collaborative groups Australia, Europe, North America. Clinical trial registry...
ALMA observations have revealed the presence of dust in first generations galaxies Universe. However, temperature $T_d$ remains mostly unconstrained due to few available FIR continuum data at redshift $z>5$. This introduces large uncertainties several properties high-$z$ galaxies, namely their masses, infrared luminosities, and obscured fraction star formation. Using a new method based on simultaneous [CII] 158$\mu$m line underlying measurements, we derive $T_ d$ detected $z\approx 7$ Large...
We analyse FIR dust continuum measurements for 14 galaxies ($z\approx 7$) in the ALMA REBELS LP to derive their physical properties. Our model uses three input data: (a) UV spectral slope, $\beta$, (b) observed flux at $1500$A, $F_{\rm UV}$, (c) $\approx 158\mu$m, $F_{158}$, and considers Milky Way (MW) SMC extinction curves, along with different geometries. find that have (28-90.5)% of star formation obscured; total (UV+IR) rates are range $31.5 < {\rm SFR}/ (M_\odot yr}^{-1}) 129.5$. The...
We present JADES JWST/NIRSpec spectroscopy of GN-z11, the most luminous candidate $z>10$ Lyman break galaxy in GOODS-North field with $M_{UV}=-21.5$. derive a redshift $z=10.603$ (lower than previous determinations) based on multiple emission lines our low and medium resolution spectra over $0.8-5.3 μ$m. significantly detect continuum measure blue rest-UV spectral slope $β=-2.4$. Remarkably, we see spatially-extended Lyman-$α$ (despite highly-neutral IGM expected at this early epoch),...
Context. To gain insight on the mass assembly and place constraints star formation history (SFH) of Lyman break galaxies (LBGs), it is important to accurately determine their properties.
BackgroundFew studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We specific each 16 types AYA cancer.MethodsThe Teenage Young Adult Cancer Survivor Study is a population-based cohort 200 945 survivors cancer diagnosed when aged 15–39 years in England Wales from Jan 1, 1971, to Dec 31, 2006. The was established using registrations Office for National Statistics Welsh registry. Follow-up 5-year survival until first occurrence...
The optimal treatment for advanced leiomyosarcoma is still debated. Given histotype-specific prospective controlled data lacking, this study retrospectively evaluated doxorubicin plus dacarbazine, ifosfamide, and alone as first-line treatments advanced/metastatic treated at European Organization Research Treatment of Cancer Soft Tissue Bone Sarcoma Group (EORTC-STBSG) sites.The inclusion criteria were a confirmed histological diagnosis, between January 2010 December 2015, measurable disease...
BACKGROUND There is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy standard except for stage I, grade 1 disease, whereas surgery alone in pediatric patients. To determine role chemotherapy, pooled analysis and clinical trials was conducted. METHODS Data from 7 2 were merged Malignant Germ Cell International Collaborative data set. Four included patients with newly diagnosed pure ITs selected (Pediatric Oncology...
ABSTRACT With JWST, new opportunities to study the evolution of galaxies in early Universe are emerging. Spitzer constraints on rest-optical properties z ≳ 7 demonstrated power using galaxy stellar masses and star formation histories (SFHs) indirectly infer cosmic history. However, only brightest individual 8 objects could be detected with Spitzer, making it difficult robustly constrain activity at 10. Here, we leverage greatly improved sensitivity JWST ages seven UV-bright ($M_{\rm...
The onset of the {\it JWST}-era provides a much-improved opportunity to characterize resolved structure early star forming systems. Previous Spitzer} observations $z\gtrsim 6$ galaxies revealed presence old stars and luminous HII regions (via [OIII]+H$\beta$ emission), but poor resolution stunted our ability map their locations with respect identified in rest-UV. In this paper, we investigate internal 12 most $z\simeq 6-8$ EGS field observed recent JWST}/NIRCam imaging. systems appear clumpy...
•Cancers in AYAs are rare.•Cancers increasing the current era.•Breast, cervical and thyroid cancers account for a substantial burden of cancer among AYAs, especially young women.•Differences AYA incidence mortality exist within European countries.•Eastern countries lagging behind survival many types AYAs. BackgroundCancer epidemiology is unique adolescents adults (AYAs; aged 15-39 years). The Society Medical Oncology/European Paediatric Oncology (ESMO/SIOPE) Working Group aims to describe...