A5026066119- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Multiple and Secondary Primary Cancers
- Chemotherapy-induced cardiotoxicity and mitigation
- Adolescent and Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related cognitive impairment studies
- melanin and skin pigmentation
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Cardiac, Anesthesia and Surgical Outcomes
- Tumors and Oncological Cases
- Molecular Biology Techniques and Applications
- Genomics and Rare Diseases
- Statistical Methods in Clinical Trials
- Cancer Risks and Factors
- Misinformation and Its Impacts
NHS Digital
2022-2024
NHS England
2024
University of South Wales
2023
Public Health England
2017-2022
National Cancer Registration Service
2019-2022
University of Birmingham
2016-2020
Analytical Services
2019
University of Leeds
2014-2017
Royal Hospital for Sick Children
2016-2017
Royal Hospital for Children
2016-2017
BackgroundFew studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We specific each 16 types AYA cancer.MethodsThe Teenage Young Adult Cancer Survivor Study is a population-based cohort 200 945 survivors cancer diagnosed when aged 15–39 years in England Wales from Jan 1, 1971, to Dec 31, 2006. The was established using registrations Office for National Statistics Welsh registry. Follow-up 5-year survival until first occurrence...
Background: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly cardiac disease that increased in other populations where cardiotoxic treatments have been used. Methods: The Teenage Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors diagnosed at 15 to 39 years age England Wales from 1971 2006, followed 2014. Standardized mortality ratios, absolute excess cumulative...
Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk delivering premature and low-birthweight offspring, but little is known about whether may also be associated additional complications during pregnancy labor. We investigated the developing labor among female in British Childhood Cancer Survivor Study (BCCSS).Pregnancy were identified by linking BCCSS cohort (n = 17 980) Hospital Episode Statistics (HES) for England. Relative risks...
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and mortality. The aim the pan-European PanCare Adolescent Cancer Survivor Care Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence risk factors for these effects among childhood in Europe. This paper describes methodology collection overall PanCareSurFup cohort outcome-related cohorts. In 13 providers 12 countries delivered centre Mainz. Data used single...
Background: Survivors of teenage and young adult cancer are at risk cerebrovascular events, but the magnitude extent to which this varies by type, decade diagnosis, age attained remains uncertain. This is largest-ever cohort study evaluate risks hospitalization for a event among long-term survivors cancer. Methods: The population-based TYACSS (Teenage Young Adult Cancer Survivor Study) (N=178,962) was linked Hospital Episode Statistics data England investigate 5-year diagnosed when 15 39...
We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For first time, we satisfactorily address beyond 40 years from diagnosis age among all survivors. This largest-ever assembled cohort comprises 69 460 five-year survivors diagnosed before 20 years. Standardized incidence ratios, absolute excess risks, multivariable-adjusted relative were calculated. All statistical tests two-sided. Overall, 21.65 times (95% confidence...
Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks specific STS histological subtypes unknown. We quantified after types childhood cancer. pooled data from 13 European cohorts, yielding a cohort 69 460 five-year Standardized incidence ratios (SIRs) and absolute excess (AERs) were calculated. Overall, 301 developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] 14.0 to 17.6). The highest standardized for malignant...
The Be Clear on Cancer (BCoC) campaigns have run in England since 2010. They aim to raise awareness of possible cancer symptoms, encouraging people consult a general practice with these symptoms. Our study provides an overview the impact 11 national campaigns, for bowel, lung, bladder and kidney, breast oesophago-gastric cancers. We synthesised existing results each campaign covering seven clinical metrics across patient pathway from primary care attendances one-year net survival. For...
At least 17 genomic regions are established as harboring melanoma susceptibility variants, in most instances with genome‐wide levels of significance and replication independent samples. Based on single nucleotide polymorphism (SNP) data augmented by imputation to the 1,000 Genomes reference panel, we have fine mapped these over 5,000 individuals (mainly from GenoMEL consortium) 7,000 ethnically matched controls. A penalized regression approach was used discover those SNP markers that...
Background Exposure to radiation and/or chemotherapy during cancer treatment can compromise respiratory function. We investigated the risk of long-term mortality among 5-year survivors diagnosed before age 40 years using British Childhood Cancer Survivor Study (BCCSS) and Teenage Young Adult (TYACSS). Methods The BCCSS comprises 34 489 15 from 1940 2006 in Great Britain. TYACSS includes 200 945 between 39 1971 England Wales. Standardised ratios absolute excess risks were used. Findings...
Abstract Background Cause-specific and relative survival estimates differ. We aimed to examine these differences in common cancers where by possible identifying the most plausible sources of error each estimate. Methods Ten-year cause-specific were estimated for lung, breast, prostate, ovary, oesophagus colorectal cancers. The was corrected misclassification cause death. Pohar-Perme estimator modified (1) correcting deaths from ischaemic heart disease (IHD) between general population; or (2)...
Survivors of childhood cancer treated with cranial irradiation are at risk cerebrovascular disease (CVD), but the risks beyond age 50 unknown. In all, 13457 survivors included in population-based British Childhood Cancer Survivor Study cohort were linked to Hospital Episode Statistics data for England. Risk CVD related hospitalisation was quantified by standardised ratios (SHRs), absolute excess and cumulative incidence. Overall, 315 (2.3%) had been hospitalised least once a 4-fold compared...
Abstract Background A two-phase ‘respiratory symptoms’ mass media campaign was conducted in 2016 and 2017 England raising awareness of cough worsening shortness breath as symptoms warranting a general practitioner (GP) visit. Method prospectively planned pre–post evaluation done using routinely collected data on 15 metrics, including GP attendance, referral, emergency presentations, cancers diagnosed (five metrics), cancer stage, investigations (two outpatient attendances, inpatient...
Background Survivors of childhood cancer are at risk subsequent primary neoplasms (SPNs), but the developing specific digestive SPNs beyond age 40 years remains uncertain. We investigated risks within largest available cohort worldwide. Methods The PanCareSurFup includes 69 460 five-year survivors from 12 countries in Europe. Risks were quantified using standardised incidence ratios (SIRs), absolute excess and cumulative incidence. Results 427 (214 colorectal, 62 liver, 48 stomach, 44...
More than a third of women diagnosed with breast cancer in England, and over half those who die from it, are 70. The Be Clear on Cancer Breast Women 70 Campaign, running three times, 2014-2018, aimed to promote early diagnosis England by raising symptom awareness encouraging see their general practitioner (GP) without delay. We sought establish whether the campaign had successfully met its aims.Metrics covering patient pathway, including awareness, attending GP practice symptoms, urgent...
To assess the impact of fourth Be Clear on Cancer (BCoC) 'Blood in Pee' (BiP) campaign (July to September 2018) bladder and kidney cancer symptom awareness outcomes England.In this uncontrolled before after study, reported barriers GP attendance were assessed using panel one-to-one interviews. The Health Improvement Network (THIN), National Registration Analysis Service (NCRAS) NHS Waiting Times (CWT) data analysed attendances, urgent referrals, diagnoses 1-year survival. Analyses used...
ABSTRACT Background Emergency diagnosis of cancer is associated with poorer short-term survival and may reflect delayed help-seeking. Optimal targeting interventions to raise awareness symptoms therefore needed. Methods We examined the risk emergency presentation lung colorectal (diagnosed in 2016 England). By site, we used logistic regression (outcome emergency/non-emergency presentation) adjusting for patient-level variables (age, sex, deprivation ethnicity) with/without adjustment...
Patients with incurable breast cancer may be treated chemotherapy to improve cancer-related symptoms, quality of life and survival. We examined the association between use palliative towards end in patients outcomes including unplanned hospital admission place death.A total 10,966 women, for (diagnosed 1995-2017 England) within 2 years prior death (death 2014 2017), were analysed. Logistic regression (outcome = emergency last 90 days yes/no; outcome hospital/other) was performed, adjusting...
A regional 'Be Clear on Cancer' (BCoC) campaign developed by Public Health England aimed to promote public awareness of key abdominal cancer symptoms in people aged 50 years and over.Data were analysed for metrics at different stages the patient care pathway including awareness, GP attendance referrals, diagnosis.There was significantly higher recognition BCoC region compared control area (Post Campaign/Control, n = 401/406; 35% vs. 24%, p < 0.05). The improved knowledge 'bloating' as a...