A5026038364- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- SARS-CoV-2 and COVID-19 Research
- Neuroblastoma Research and Treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Global Cancer Incidence and Screening
- Adolescent and Pediatric Healthcare
- Health disparities and outcomes
- Glioma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Palliative Care and End-of-Life Issues
- Cancer Risks and Factors
- Social Sciences and Governance
- Ion channel regulation and function
- Torture, Ethics, and Law
- Autism Spectrum Disorder Research
- Vitamin K Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Angiogenesis and VEGF in Cancer
- Effects of Radiation Exposure
Piedmont Reference Center for Epidemiology and Cancer Prevention
2007-2024
University of Turin
1989-2024
National Centre for Disease Prevention and Control
2020
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2017-2019
Ospedale Regina Margherita
2015
Ospedale San Giovanni Bosco
1994
This study was designed to identify the set of functions activated in cultured endothelial cells by hematopoietic growth factors, granulocyte colony-stimulating factor (G-CSF) and macrophage-colony-stimulating (GM-CSF), compare them with those elicited prototypic cytokines active on these cells. Moreover, indications as vivo relevance vitro effects were obtained. G-CSF GM-CSF induced proliferate migrate. In contrast, unlike appropriate reference (IL-1 tumor necrosis factor, IFN-gamma), did...
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and mortality. The aim the pan-European PanCare Adolescent Cancer Survivor Care Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence risk factors for these effects among childhood in Europe. This paper describes methodology collection overall PanCareSurFup cohort outcome-related cohorts. In 13 providers 12 countries delivered centre Mainz. Data used single...
Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks specific STS histological subtypes unknown. We quantified after types childhood cancer. pooled data from 13 European cohorts, yielding a cohort 69 460 five-year Standardized incidence ratios (SIRs) and absolute excess (AERs) were calculated. Overall, 301 developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] 14.0 to 17.6). The highest standardized for malignant...
Abstract Background Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years uncertain. We quantified these in largest ever cohort. Methods Using data from 69,460 5-year childhood (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) cumulative were calculated. Results In total, 279 glioma 761 meningioma identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) leukaemia 11.2, 8.8, 14.2) greatest glioma. The SIR for was...
It has been shown that human endothelial cells (HEC)are stimulated to migrate and proliferate by granulocyte (G)and granulocyte-macrophage (GM)-colonystimulating factor (CSF) (Bussolino, F.,
• In chylous fistulas following radical neck dissections, we have found reexploration to be unrewarding, with infrequent identification of a specific leakage site intraoperatively and persistent fluid accumulation postoperatively. As an alternative, injected tetracycline hydrochloride into the supraclavicular wound bed. This procedure resulted in rapid, sustained decline fistula output two three cases, avoiding surgical intervention. Tetracycline sclerotherapy has been described for...
In the past, increases in childhood cancer incidence were reported Europe and North America. The aim of this study is to show updated patterns temporal behavior using data Childhood Cancer Registry Piedmont (CCRP), a region with approximately 4.5 million inhabitants North-West Italy. CCRP has been recording incident cases children (0-14 years) since 1967 adolescents (15-19) 2000. Time trends estimated as annual percent change (APC) over 1976-2011 period for children, 2000-2011 both...
Long-term consequences of childhood cancer encompass adverse psychosocial effects that may severely limit the opportunity to live a satisfying and productive life. We assessed social integration adults cured in their first 14 years life by record linkage between population-based Childhood Cancer Registry Piedmont Turin Longitudinal Study. compared education employment outcomes within cohort survivors peers general population through logistic regression. Individuals tumour have higher risk...
Background: Healthcare workers (HCWs) have been the key players in fight against coronavirus disease 2019 (COVID-19) pandemic. The aim of our study was to evaluate seroprevalence severe acute respiratory syndrome 2 (SARS-CoV-2) IgG anti-bodies. Methods: We conducted a cross-sectional among two hospitals and Territorial Medical Administrative services Northern Italy. From 8 May 3 June 2020, 2252 subjects were tested. Seroprevalence 95% confidence interval (CI) calculated for all individuals...
The majority of childhood cancer cases survive to adulthood. We describe the experience marriage and reproduction as indicators quality life, in a population-based cohort adult long-term survivors after early reported Childhood Cancer Registry Piedmont. study included 1237 with malignant neoplasm diagnosed during 1967–2000 when aged 0–14 years, who attained age 18 years. Vital marital status number offspring were assessed through Statistics Offices. Marriage fertility deficits estimated by...
Abstract Background Several nonbiological factors, including socioeconomic status indicators and other family characteristics, influence survival from childhood cancers. Our study explores the association between parental education cancer survival. Methods The specialized Childhood Cancer Registry of Piedmont region in Italy provided data on all cases (aged 0–14) diagnosed with period 1976–2011 who resided city Turin (capital region) at least once since 1971. Information was extracted...
In this report, we determine the cumulative incidence of symptomatic cardiac ischaemia and its risk factors among European 5-year childhood cancer survivors (CCS) participating in PanCareSurFup study.Eight data providers (France, Hungary, Italy (two cohorts), Netherlands, Slovenia, Switzerland UK) ascertained validated events their 36 205 eligible CCS. Data on were graded according to Criteria for Adverse Events V.3.0 (grade 3-5). We calculated incidences, both overall different subgroups...
Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence factors for events among childhood survivors. aim this article is to describe methodology cohort nested case-control within PanCareSurFup. Methods Eight data providers in Europe participating identified validated symptomatic their cohorts Data on heart failure, ischemia, pericarditis, valvular...
Background Survivors of childhood cancer are at risk subsequent primary neoplasms (SPNs), but the developing specific digestive SPNs beyond age 40 years remains uncertain. We investigated risks within largest available cohort worldwide. Methods The PanCareSurFup includes 69 460 five-year survivors from 12 countries in Europe. Risks were quantified using standardised incidence ratios (SIRs), absolute excess and cumulative incidence. Results 427 (214 colorectal, 62 liver, 48 stomach, 44...
The aim of this study was to compare the characteristics respondents and nonrespondents in a survey childhood cancer survivors recorded Childhood Cancer Registry Piedmont their current primary care general practitioners. Eligible subjects were identified from referring practitioners traced through National Health Service. A postal questionnaire sent both Prevalence odds ratios estimated for demographic clinical total 1005 857 (132 them had two or more care) included study. Completed...
Abstract Background Cancer stage is a determinant of survival childhood central nervous system (CNS) cancers and could help the interpretation variability among countries. Consensus guidelines to malignancies in population cancer registries (“Toronto Childhood Stage Guidelines”) have been recently proposed with goal data comparability. Indeed, not systematically recorded all and, when it is, different classification systems are used. We applied Toronto Guidelines CNS cases three...
Abstract Background Survivors of Hodgkin lymphoma (HL) are at risk developing non‐Hodgkin (NHL) after treatment; however, the risks subsequent primary lymphomas (SPLs), including HL and NHL, different types childhood cancer unknown. The authors quantified SPLs using largest cohort survivors worldwide. Methods Pan‐European Network for Care After Childhood Adolescent Cancer (PanCare) Survivor Follow‐Up Studies (PanCareSurFup) includes 69,460 five‐year cancer, diagnosed during 1940 through...
Background to avoid a new spread of the SARS-CoV-2 infection, post lockdown period requires implementation effective strategies for case finding and contact tracing. The presence asymptomatic subjects in population, that are responsible about 30% infections, may complicate this phase. Serological tests measurement immune response could represent an tool rapid monitoring population with infections estimating proportion territory, too. Objectives describe distribution infection Municipality...