A5055079124- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- Glioma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuroblastoma Research and Treatments
- Ocular Oncology and Treatments
- Palliative Care and End-of-Life Issues
- Renal and related cancers
- Cancer Risks and Factors
- Adolescent and Pediatric Healthcare
- Ethics and Legal Issues in Pediatric Healthcare
- Radiation Dose and Imaging
- Multiple and Secondary Primary Cancers
- Acute Myeloid Leukemia Research
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Thyroid Cancer Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Chronic Kidney Disease and Diabetes
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
University of Birmingham
2015-2024
Universidad El Bosque
2024
Emory University
1990-2024
European Organisation for Research and Treatment of Cancer
2021
Health Affairs
2021
University of Oxford
1991-2017
Churchill Hospital
2010-2017
Great Ormond Street Hospital for Children NHS Foundation Trust
2017
Birmingham Children's Hospital
2016
University College London
2010-2016
BACKGROUND Cerebral oedema is a major cause of morbidity and mortality in children with insulin dependent diabetes. AIMS To determine the risk outcome cerebral complicating diabetic ketoacidosis (DKA). METHODS All cases England, Scotland, Wales were reported through British Paediatric Surveillance Unit between October 1995 September 1998. episodes DKA by 225 paediatricians identified as involved care diabetes separate reporting system March 1996 February Further information about...
Individuals who had cancer in childhood are at higher risk of developing bone than any other type second primary cancer. Using the population-based National Registry Childhood Tumours Britain, we investigated incidence and etiology after a cohort study case–control study. A 13 175 3-year survivors diagnosed Britain between 1940 1983 revealed 55 subsequent cancers. largely nested comprised 59 case subjects cancer, 220 control were selected matched for sex, first age interval diagnosis Outcome...
In Britain 75% of individuals diagnosed with childhood cancer survive at least 5 years. The British Childhood Cancer Survivor Study was established to determine the risks adverse health and social outcomes among survivors. To be eligible were in between 1940 1991 survived entire cohort 17,981 form basis population-based studies late mortality risks/causes second malignant neoplasms using national registration systems.A postal questionnaire sent survivors who alive aged 16 years via their...
To assess prospectively the relationship between microalbuminuria and mortality in a geographically defined population of NIDDM patients to determine relative importance as risk factor for mortality.A survey known diabetes undertaken 1982 identified cohort 249 patients. Follow-up information was available 246 who contributed 1498 person-yr exposure were followed up mean period 6.1 yr. The median age at entry 68 yr (range 28-89 yr), duration 7 1-41 yr). At baseline, clinical examination...
Osteosarcoma is the most frequent second primary cancer occurring during first 20 years following treatment for a solid in childhood. Using cohort study of children treated cancer, we investigated incidence and etiology osteosarcoma as malignant neoplasm after childhood case-control study. We analysed relationship between local dose radiation risk osteosarcoma, taking into account chemotherapy received. A 4,400 3-year survivors diagnosed France or United Kingdom, 1942 1986, revealed 32...
Context: A number of retrospective studies report that patients with acromegaly have increased morbidity and premature mortality, standardized mortality ratios (SMR) 1.3–3. Many develop hypopituitarism as a result the pituitary adenoma itself or therapies such surgery radiotherapy. Pituitary radiotherapy also been associated an SMR.
Purpose CNS tumors are the most common second primary neoplasm (SPN) observed after childhood cancer in Britain, but relationship of risk to doses previous radiotherapy and chemotherapy is uncertain. Methods The British Childhood Cancer Survivor Study a national, population-based, cohort study 17,980 individuals surviving at least 5 years diagnosis cancer. Linkage population-based registries identified 247 SPNs CNS. Cohort nested case-control studies were undertaken. Results There 137...
Studies have causally linked external thyroid radiation exposure in childhood with cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although cancer therapies can result doses >50 Gy. We 12 studies patients who exposed to (ages <20 years), more than doubling the data, including 1,070 (927 exposed) cancers and 5.3 million (3.4 person-years. Relative risks increased supralinearly through 2–4 leveled off...
The increased use of diagnostic and therapeutic procedures that involve radiation raises concerns about effects, particularly in children the radiosensitive thyroid gland. Evaluation relative risk (RR) trends for doses <0.2 gray (Gy); evidence a threshold dose; possible modifiers dose-response, e.g., sex, age at exposure, time since exposure. Pooled data from nine cohort studies childhood external exposure cancer with individualized dose estimates, ≥1000 irradiated subjects or ≥10 cases,...
<b>Objective</b> To determine whether modern treatments for cancer are associated with a net increased or decreased risk of death from neoplastic and non-neoplastic causes among survivors childhood cancer. <b>Design</b> Population based cohort study. <b>Setting</b> British Childhood Cancer Survivor Study. <b>Participants</b> Nationwide population 34 489 five year diagnosis 1940 to 2006 followed up until 28 February 2014. <b>Main outcome measures</b> Cause specific...
BackgroundFew studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We specific each 16 types AYA cancer.MethodsThe Teenage Young Adult Cancer Survivor Study is a population-based cohort 200 945 survivors cancer diagnosed when aged 15–39 years in England Wales from Jan 1, 1971, to Dec 31, 2006. The was established using registrations Office for National Statistics Welsh registry. Follow-up 5-year survival until first occurrence...
Retinoblastoma is an eye tumour of childhood that occurs in heritable and non-heritable forms. In the form, there a predisposition to development non-ocular subsequent primary tumours (SPTs). This study included 1927 retinoblastoma patients diagnosed Britain from 1951 2004. Ascertainment was through (UK) National Registry Childhood Tumours; cases were followed-up for occurrence SPTs. Standardised incidence ratios (SIRs) calculated. We identified 169 SPTs 152 patients. The SIR analysis 145...
Childhood cancer five-year survival now exceeds 70–80%. exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of dose-response at high doses, modifiers relationship and joint effects radiotherapy chemotherapy. To address these issues, we pooled two cohort nested case-control studies childhood survivors including 16,757 patients, with 187 developing primary cancer. Relative risks (RR) 95% confidence intervals (CI) by treatment alkylating agents,...
In a population-based, retrospective cohort study of 16 541 3-year survivors childhood cancer treated in Britain up to the end 1987, 278 second malignant neoplasms (SMNs) were identified against 39.4 expected giving standardised incidence ratio (SIR) 6.2. The overall cumulative risk an SMN by 25 years from survival was 4.2%. Analysis nonretinoblastoma cancers combined revealed significant decline SIR with increasing duration follow-up. There greater developing SMN, particularly secondary...
A postal survey addressed to 2,083 general practitioners of childhood cancer survivors reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk several adverse pregnancy outcomes as compared with female the same types tumour who had not (unexposed). Among survivors, 22% those exposed and 41% unexposed children. The percentages first pregnancies reported ending in spontaneous abortion were 9/40 =...
The variation in the risk of solid second malignant neoplasms (SMN) with time since first cancer during childhood has been previously reported. However, no study performed that controls for distribution radiation dose and aggressiveness past chemotherapy, which could be responsible observed temporal risk. purpose this was to investigate influence treatment on long-term pattern incidence SMN after a childhood. We studied cohort 4400 patients from eight centres France UK. Patients had alive 3...
To obtain information on the prevalence and clinical laboratory correlates of osteopenia in patients with chronic liver disease, we measured bone densities 30 selected variables 133 subjects (70 men, 63 women) disease. Thirty-two had alcoholic 18 primary biliary cirrhosis, 16 sclerosing cholangitis, 48 other forms cirrhosis (cryptogenic, posthepatic) 19 hepatitis or fibrosis without cirrhosis. Bone lumbar spine three sites proximal femur (neck, Ward's triangle, greater trochanter) were...
<h3>Background</h3> The thyroid gland is among the most radiosensitive organs. However, little known about long-term risk of developing a tumor after fractionated external radiotherapy for cancer during childhood. <h3>Objective</h3> To study in 4096 three-year survivors childhood treated between May 1942 and December 1985 8 centers France United Kingdom, 2827 whom had received radiotherapy. <h3>Methods</h3> A wide range radiation doses were given to thyroid: 1164 children less than 0.5 Gy...
Previous studies of educational attainment among childhood cancer survivors were small, had contradictory findings, and not population based. This study investigated in a large population-based cohort all types Great Britain. Four levels 10 183 survivors—degree, teaching qualification, advanced (A') levels, ordinary (O') levels—were compared with expected the general population. A questionnaire was used to obtain data for survivors, comparable information available from General Household...
Increased risks of cardiac morbidity and mortality among childhood cancer survivors have been described previously. However, little is known about the very long-term whether risk has decreased those more recently diagnosed. We investigated within extended British Childhood Cancer Survivor Study.
Survivors of Wilms tumor (WT) are at risk for adverse health and social outcomes but risks beyond 30 years from diagnosis remain uncertain. We investigated the among 5-year survivors WT, in particular, those between 50 diagnosis.The British Childhood Cancer Survivor Study includes 1,441 WT. cause-specific mortality, subsequent primary neoplasms (SPNs), and, who completed a questionnaire, extent smoking drinking, educational achievement, status, service use compared with general...