A5064593537- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Cancer Risks and Factors
- Radiation Therapy and Dosimetry
- Radioactivity and Radon Measurements
- Radioactive contamination and transfer
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Alcohol Consumption and Health Effects
- Carcinogens and Genotoxicity Assessment
- Risk Perception and Management
- Nutritional Studies and Diet
- Occupational and environmental lung diseases
- Ovarian cancer diagnosis and treatment
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Climate Change and Health Impacts
- Global Health Care Issues
- Health disparities and outcomes
- Hepatitis C virus research
- Polyamine Metabolism and Applications
- Nonmelanoma Skin Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Radiation Effects Research Foundation
2016-2025
Leidos (United States)
2016
Fukushima Medical University
2015
National Institutes of Health
2012
Fred Hutch Cancer Center
2010
Cancer Research Center
2010
University of Washington
2010
National Cancer Institute
2010
Division of Cancer Epidemiology and Genetics
2010
National Sanyo Hospital
2009
This is the 14th report in a series of periodic general reports on mortality Life Span Study (LSS) cohort atomic bomb survivors followed by Radiation Effects Research Foundation to investigate late health effects radiation from bombs. During period 1950–2003, 58% 86,611 LSS members with DS02 dose estimates have died. The 6 years additional follow-up since previous provide substantially more information at longer periods after exposure (17% cancer deaths), especially among those under age 10...
<b>Objective</b> To investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke. <b>Design</b> Prospective cohort study with more than 50 years follow-up. <b>Setting</b> Atomic bomb survivors in Hiroshima Nagasaki, Japan. <b>Participants</b> 86 611 Life Span Study members individually estimated doses 0 >3 Gy (86% received <0.2 Gy). <b>Main outcome measures</b> Mortality stroke or as underlying cause death dose-response relations atomic...
This is the third analysis of solid cancer incidence among Life Span Study (LSS) cohort atomic bomb survivors in Hiroshima and Nagasaki, adding eleven years follow-up data since previously reported analysis. For this analysis, several changes improvements were implemented, including updated dose estimates (DS02R1) adjustment for smoking. Here, we focus on all cancers aggregate. The eligible included 105,444 subjects who alive had no known history at start follow-up. A total 80,205 individual...
Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.To assess the factors, such as number deliveries, age at menarche, or menopause, risk.This cohort study used pooled individual data from 13 1963 2014 Asia Cohort Consortium. Participants were Asian women. Data analysis was September 2019 to April 2023.Reproductive assessed using a questionnaire each cohort.The main outcome time...
Studies have causally linked external thyroid radiation exposure in childhood with cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although cancer therapies can result doses >50 Gy. We 12 studies patients who exposed to (ages <20 years), more than doubling the data, including 1,070 (927 exposed) cancers and 5.3 million (3.4 person-years. Relative risks increased supralinearly through 2–4 leveled off...
The increased use of diagnostic and therapeutic procedures that involve radiation raises concerns about effects, particularly in children the radiosensitive thyroid gland. Evaluation relative risk (RR) trends for doses <0.2 gray (Gy); evidence a threshold dose; possible modifiers dose-response, e.g., sex, age at exposure, time since exposure. Pooled data from nine cohort studies childhood external exposure cancer with individualized dose estimates, ≥1000 irradiated subjects or ≥10 cases,...
<b>Objective</b> To investigate the impact of smoking on overall mortality and life expectancy in a large Japanese population, including some who smoked throughout adult life. <b>Design</b> The Life Span Study, population-based prospective study, initiated 1950. <b>Setting</b> Hiroshima Nagasaki, Japan. <b>Participants</b> Smoking status for 27 311 men 40 662 women was obtained during 1963-92. Mortality from one year after first ascertainment until 1 January 2008 has been analysed. <b>Main...
Childhood cancer five-year survival now exceeds 70–80%. exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of dose-response at high doses, modifiers relationship and joint effects radiotherapy chemotherapy. To address these issues, we pooled two cohort nested case-control studies childhood survivors including 16,757 patients, with 187 developing primary cancer. Relative risks (RR) 95% confidence intervals (CI) by treatment alkylating agents,...
The Fukushima Health Management Survey (including the Basic for external dose estimation and four detailed surveys) was launched after Dai-ichi Nuclear Power Plant accident. consists of a questionnaire that asks Prefecture residents about their behavior in first months accident; responses to have been returned from many residents. individual doses are estimated by using digitized data computer program included daily gamma ray rate maps drawn 421,394 (excluding radiation workers) had...
The importance of reproductive history in breast tissue development and etiology sporadic cancer females is well established. However, there limited evidence factors, other than age, that modify risk radiation-related cancer. In this study, we evaluated incidence the Life Span Study cohort atomic bomb survivors, adding 11 years follow-up incorporating data. We used Poisson regression models to describe radiation risks modifying effects age factors. Among 62,534 females, identified 1,470...
Recent analysis of all solid cancer incidence (1958–2009) in the Life Span Study (LSS) revealed evidence upward curvature radiation dose response among males but not females. Upward sex-averaged excess relative risk (ERR) for mortality (1950–2003) was also observed 0–2 Gy range. As reasons non-linearity LSS are completely understood, we conducted dose-response analyses and applying similar methods [1958–2009 follow-up, DS02R1 doses, including subjects not-in-city (NIC) at time bombing]...
This paper provides the first comprehensive report on mortality by type of leukemia among Japanese atomic bomb survivors in Life Span Study (LSS). Analyses include 310 deaths due to during period 1950-2000 86,611 people LSS. Poisson regression methods were used evaluate associations between estimated bone marrow dose and mortality. Attention was given variation radiation dose-leukemia association time since exposure, age at city sex. The excess relative rate per gray acute myeloid best...
We examined the relation between coffee drinking and hepatocellular carcinoma (HCC) mortality in Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). In total, 110,688 cohort members (46,399 male 64,289 female subjects) aged 40-79 years were grouped by intake into three categories: one or more cups per day, less than cup day non-coffee drinkers. Cox proportional hazards model SAS was used to obtain hazard ratio HCC each consumption categories. The ratios adjusted age,...
Individual dose estimates calculated by Dosimetry System 2002 (DS02) for the Life Span Study (LSS) of atomic bomb survivors are based on input data that specify location and shielding at time bombing (ATB). A multi-year effort to improve information survivors’ locations ATB has recently been completed, along with comprehensive improvements in their terrain several computational algorithms used combination DS02 RERF. Improvements began a thorough review prioritization original questionnaire...
Radiation effects on colorectal cancer rates, adjusted for smoking, alcohol intake and frequency of meat consumption body mass index (BMI) by anatomical subsite (proximal colon, distal colon rectum) were examined in a cohort 105,444 atomic bomb survivors. Poisson regression methods used to describe radiation‐associated excess relative risks (ERR) absolute rates (EAR) the 1958–2009 period. There 2,960 first primary cancers including 894 proximal, 871 1,046 rectal cancers. Smoking, BMI...
As a follow-up to the comprehensive work on solid cancer incidence in Life Span Study (LSS) cohort of atomic bomb survivors between 1958 and 1998, we report here updated radiation risk estimates for upper digestive tract cancers. In this study, added 11 years (1958–2009), used improved dose estimates, considered effects smoking alcohol consumption performed dose-response analyses by anatomical sub-site. examining 52 years'worth data, ascertained occurrence 394 oral cavity/pharyngeal cancers,...
To explore the association between dietary habits and risk of hepatocellular carcinoma (HCC) mortality in Japan, univariate analyses was performed using data from JACC Study. A cohort 46, 465 males 64, 327 females aged 40 to 79 19 prefectures Japan completed baseline survey during 1988-1990 were followed up until end 1999. The hazard ratio (HR) HCC for each food item by gender, age group (40-59 60-79 years) history liver diseases obtained Cox proportional hazards model. Some categories, such...
Whole-body and thoracic ionizing radiation exposure are associated with increased cardiovascular disease (CVD) risk. In atomic bomb survivors, dose is also hypertension incidence, suggesting that may be chronic renal failure (CRF), thus explaining part of the mechanism for CVD. Multivariate Poisson regression was used to evaluate association various definitions kidney (CKD) mortality in Life Span Study (LSS) survivors. A secondary analysis performed using a subsample whom self-reported...
The Life Span Study (LSS) of atomic bomb survivors has consistently demonstrated significant excess radiation-related risks liver cancer since the first incidence report. Here, we present updated information on radiation liver, biliary tract and pancreatic cancers based 11 additional years follow-up last report, from 1958 to 2009. current analyses used improved individual doses accounted for effects alcohol consumption, smoking body mass index. study participants included 105,444 LSS with...
From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes among births atomic bomb survivors (Hiroshima and Nagasaki, Japan) who had received radiation doses ranging from 0 Gy near-lethal levels. Past reports (1956, 1981, 1990) on cohort did not identify significant associations exposure with untoward outcomes, such as major congenital malformations, stillbirths, or neonatal deaths, individually in aggregate. We reexamined risk malformations perinatal...