Martin G. McCabe
A5004593954- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Lymphoma Diagnosis and Treatment
- Oral health in cancer treatment
- Acute Lymphoblastic Leukemia research
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer-related cognitive impairment studies
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Palliative Care and End-of-Life Issues
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Family Support in Illness
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Adolescent and Pediatric Healthcare
- Management of metastatic bone disease
- MicroRNA in disease regulation
- Cancer therapeutics and mechanisms
University of Manchester
2016-2025
The Christie NHS Foundation Trust
2010-2025
Northern Health and Social Care Trust
2025
Cancer Research UK Manchester Institute
2014-2024
The Christie Hospital
2016-2024
Manchester Academic Health Science Centre
2014-2023
Korea Association of Teachers of English
2023
ORCID
2023
Great Ormond Street Hospital for Children NHS Foundation Trust
2023
University of Surrey
2023
Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of samples authors show that clinically challenging Group 3 and 4 tumours can be tetraploid, reveal expression first medulloblastoma fusion genes identified. malignant children. Four papers published 2 August 2012 issue Nature use other techniques to produce a detailed picture genetics genomics this condition. Notable findings include identification recurrent mutations not previously implicated...
Heterozygous germline PTCH1 mutations are causative of Gorlin syndrome (naevoid basal cell carcinoma), but detection rates > 70% have rarely been reported. We aimed to define the in individuals with without mutations.We undertook exome sequencing on lymphocyte DNA from four unrelated families no found by Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), or RNA analysis.A heterozygous nonsense mutation SUFU was identified one exomes. 23 additional PTCH1-negative a...
BackgroundFew studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We specific each 16 types AYA cancer.MethodsThe Teenage Young Adult Cancer Survivor Study is a population-based cohort 200 945 survivors cancer diagnosed when aged 15–39 years in England Wales from Jan 1, 1971, to Dec 31, 2006. The was established using registrations Office for National Statistics Welsh registry. Follow-up 5-year survival until first occurrence...
Background: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly cardiac disease that increased in other populations where cardiotoxic treatments have been used. Methods: The Teenage Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors diagnosed at 15 to 39 years age England Wales from 1971 2006, followed 2014. Standardized mortality ratios, absolute excess cumulative...
Abstract Background Children with cancer are frequently immunocompromised. While children generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the in is unavailable. We aimed produce incidence and outcomes from attending all hospitals treating this population across UK. Methods Retrospective prospective observational study UK under 16 diagnosed through data collection providing care population. Eligible patients tested...
Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years rare children young adults. Multiple and/or meningiomas more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary do not. Nevertheless, apparently sporadic patients may herald syndrome.To determine the frequency of known heritable meningioma- or schwannoma-predisposing mutations presenting meningioma schwannoma.Using database...
Abstract Background NF2 patients develop multiple nervous system tumors including bilateral vestibular schwannomas (VS). The and their surgical treatment are associated with deafness, neurological disability, mortality. Medical bevacizumab has been reported to reduce VS growth improve hearing. In addition evaluating these effects, this study also aimed determine other important consequences of patient-reported quality life the impact on rates. Methods Patients treated underwent serial...
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. DNA methylation has emerged as useful tool for robust tumor classification, providing new insights into these heterogeneous classes. This is particularly true rare CNS with broad morphological spectrum, which are not possible...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Purpose of review There is an unmet need to improve outcomes for patients Ewing sarcoma, a rare, aggressive sarcoma with peak incidence in adolescents and young adults (AYA). Current therapy at diagnosis involves multiagent chemotherapy local therapy, but despite intensification treatment, those metastases recurrent disease have poor outcomes. Recent findings Improved understanding biology has identified novel targets promising activity patients, including tyrosine kinase inhibitors that are...
Greater collaboration needed to realize potential of molecular profiling initiatives for pediatric cancers.