A5103238933- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Acute Lymphoblastic Leukemia research
- Head and Neck Surgical Oncology
- Renal and related cancers
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Radiation Therapy and Dosimetry
- ATP Synthase and ATPases Research
- Pharmacological Effects and Toxicity Studies
- Vascular Tumors and Angiosarcomas
- Bone Tumor Diagnosis and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Neonatal Health and Biochemistry
- Oral and Maxillofacial Pathology
- Cancer therapeutics and mechanisms
- Mitochondrial Function and Pathology
Birmingham Women’s and Children’s NHS Foundation Trust
2018-2024
Birmingham Children's Hospital
2013-2024
Birmingham Women's Hospital
2020-2022
Society of Paediatric Oncology and Haematology
2021
University of Birmingham
2013-2017
Boston Children's Hospital
2004-2015
Addenbrooke's Hospital
2014
University Hospitals Birmingham NHS Foundation Trust
2013
Children's of Alabama
2008
University Hospital Llandough
2002-2003
Bevacizumab is increasingly used in children with pediatric low-grade glioma (PLGG) despite limited evidence. A nationwide UK service evaluation was conducted to provide larger cohort "real life" safety and efficacy data including functional visual outcomes.Children receiving bevacizumab-based treatments (BBT) for PLGG (2009-2020) from 11 centers were included. Standardized neuro-radiological (RANO-LGG) (logMAR acuity) criteria assess clinical-radiological correlation, survival outcomes...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Background: The clinical management of ependymoma in childhood and adolescence is complex the clinicobiopathological correlates outcome remain poorly understood. This international SIOP Ependymoma II (SIOP EPII) trial aims to improve patients with ependymoma. Methods EPII includes any patient <22 years at diagnosis ependymoma, stratified by age, tumor location, initial surgery. Centralized pathology imaging required for confirmation. included three randomized studies according...
This study investigated changes and the time course of these in renal function children following treatment with carboplatin, identified risk factors for nephrotoxicity. Glomerular proximal tubular were before up to 2 years after 23 who received carboplatin. The main findings reduced glomerular filtration rate (GFR), increased loss magnesium, manifested by a low serum magnesium (S Mg). mean fall GFR was 22 ml min–1 1.73 m–2 (P = 0.012), S Mg it 0.17 mmol l–1 0.0077). No patient had...
Medulloblastoma is the most common malignant brain tumor occurring in childhood and a significant cause of morbidity mortality pediatric oncology. More intense treatment strategies are recommended for patients displaying high-risk factors; however, considerable variation outcome remains, indicating need improved predictive markers. In this study, 1H magnetic resonance spectroscopy (MRS) was used to investigate noninvasive molecular biomarkers survival medulloblastoma.MRS performed on series...
Abstract Objective The purpose of the study was to identify factors that contribute parenting stress in caregivers children diagnosed with brain tumours. Methods cross‐sectional and recruited 37 participants from a clinical database at specialist children's hospital. Parents were sent questionnaires, which used measure related tumour. Stress levels measured using Parenting Index—Short Form (PSI/SF). Correlation analysis multiple linear regression examine associations between coping styles,...
PURPOSE: Carboplatin dosing in adults with cancer is based on renal function. The purpose of the current study was to validate a previously developed pediatric carboplatin-dosing formula. PATIENTS AND METHODS: Thirty-eight patients were randomized receive carboplatin dose calculated according surface area or function–based On next course therapy, alternative method used for each patient. pharmacokinetics (based free plasma platinum concentrations) measured after both courses. RESULTS: mean...
Malignant brain tumors in children generally have a very poor prognosis when they relapse and improvements are required their management. It can be difficult to accurately diagnose abnormalities detected during tumor surveillance, new techniques aid this process. This study investigates how metabolite profiles measured noninvasively by 1H magnetic resonance spectroscopy (MRS) at reflect those diagnosis may used monitoring Single-voxel MRS (1.5 T, point-resolved spectroscopy, echo time 30 ms,...
Historically, the 5-year overall survival (OS) for metastatic medulloblastoma (MMB) was less than 40%. The strategy of post-operative induction chemotherapy (IC) followed by hyperfractionated accelerated radiotherapy (HART) and response directed high dose (HDC) reported in a single center study to improve OS 73%. We report outcomes this UK.Questionnaires were sent all 20 UK pediatric oncology primary treatment centers collect retrospective data on delivered treatment, toxicity with children...
Hepatic epithelioid haemangio-endothelioma (HEHE) is an endothelium-derived tumour of low-to-medium grade malignancy. It predominantly seen in adults and unresponsive to chemotherapy. Liver transplantation accepted indication when the unresectable. very rare children results after are not reported. The aim this study review experience three European centres management HEHE children. A retrospective all paediatric patients with managed presented. Five were identified. Four had unresectable...
With increasing survival rates for childhood cancer, late effects are of growing importance. Oral health is central to general health, level nutrition, quality life, and significant in the holistic care children during cancer therapy.The oral needs treated solid tumours/lymphoma will be greater than population, groups differ according tumour treatment.One hundred twenty patients, 0-17 years, under follow-up from 01/07/06 07/02/07 were investigated caries, opacities, microdontia, gingivitis....
Abstract Background Magnetic resonance spectroscopy (MRS) has been successful in characterising a range of brain tumours and is useful aid to non‐invasive diagnosis. The pineal region poses considerable surgical challenges major resection not required the management all tumours. Improved assessment would be benefit. Methods Single voxel MRS (TE 30 ms, TR 1500, 1.5 T) was performed on 15 tumours: 5 germinomas, 1 non‐germinomatous secreting germ cell tumour (GCT), 2 teratomas, pineoblastomas,...
Abstract Background Magnetic resonance spectroscopy (MRS) aids noninvasive diagnosis of pediatric brain tumors, but use in clinical practice is not well documented. We aimed to review MRS, establish added value diagnosis, and investigate potential impact on patient care. Methods Sixty-nine children with lesions imaged using MRS reviewed by the tumor board from 2014 2016 met inclusion criteria. Contemporaneous MRI analysis, histopathology, information were reviewed. Final was agreed at study...
Background MRI is essential to the clinical management of children and young people with brain tumours. Advances in technology have made images more complicated interpret, yet easily available digitally. It common practice show these patients families, but how they emotionally respond to, understand value, seeing tumour MRIs has not been formally studied. Methods Qualitative semi-structured interviews were undertaken 14 families (8 patients, 15 parents) purposively sampled from paediatric (0...