Sarah Jefferies
A5015927579- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 epidemiological studies
- Bone Tumor Diagnosis and Treatments
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Influenza Virus Research Studies
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Management of metastatic bone disease
- Respiratory viral infections research
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
Addenbrooke's Hospital
2015-2024
Cambridge University Hospitals NHS Foundation Trust
2014-2024
Institute of Environmental Science and Research
2020-2024
University of Cambridge
2007-2023
Bridge University
2023
National Health Service
2015-2022
Africa Centres for Disease Control and Prevention
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
Hutchison/MRC Research Centre
2018
Queen Mary University of London
2018
Xerostomia is the most common late side-effect of radiotherapy to head and neck. Compared with conventional radiotherapy, intensity-modulated (IMRT) can reduce irradiation parotid glands. We assessed hypothesis that parotid-sparing IMRT reduces incidence severe xerostomia.We undertook a randomised controlled trial between Jan 21, 2003, Dec 7, 2007, compared (control) IMRT. randomly assigned patients histologically confirmed pharyngeal squamous-cell carcinoma (T1-4, N0-3, M0) at six UK...
Abstract Stringent nonpharmaceutical interventions (NPIs) such as lockdowns and border closures are not currently recommended for pandemic influenza control. New Zealand used these NPIs to eliminate coronavirus disease 2019 during its first wave. Using multiple surveillance systems, we observed a parallel unprecedented reduction of other respiratory viral infections in 2020. This finding supports the use controlling severe threats.
To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy adjuvant temozolomide patients with newly diagnosed glioblastoma. is novel glioblastoma-specific therapeutic vaccine containing 11 tumor-associated peptides (TUMAP), identified on human leukocyte antigen (HLA) surface receptors primary glioblastoma tissue.
Abstract New Zealand, a geographically remote Pacific island with easily sealable borders, implemented nationwide ‘lockdown’ of all non-essential services to curb the spread COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in Zealand samples collected during ‘first wave’, representing 56% confirmed cases this time period. Despite its remoteness, viruses imported into represented nearly genomic diversity sequenced global virus population. These data helped...
The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib potentiated radiation and temozolomide (TMZ) chemotherapy in preclinical glioblastoma models but brain penetration was poor. Clinically, PARP inhibitors exacerbate the hematological side effects of TMZ. OPARATIC trial conducted to measure recurrent by assess safety tolerability its combination with
Abstract Background New Zealand's (NZ) complete absence of community transmission influenza and respiratory syncytial virus (RSV) after May 2020, likely due to COVID‐19 elimination measures, provided a rare opportunity assess the impact border restrictions on common viral infections over ensuing 2 years. Methods We collected data from multiple surveillance systems, including hospital‐based severe acute infection surveillance, SHIVERS‐II, ‐III ‐IV cohorts for (ARI) HealthStat sentinel general...
Abstract Purpose: Patients with recurrent high-grade gliomas (HGG) are usually managed alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs a target for arginine depletion pegargiminase (ADI-PEG20) due to epimutations of argininosuccinate synthetase (ASS1) and/or lyase (ASL). Moreover, ADI-PEG20 disrupts pyrimidine pools in ASS1-deficient HGGs, thereby impacting sensitivity the antifolate, pemetrexed. and Methods: We expanded phase I...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Glioblastoma has a dismal prognosis and molecular targeted agents have failed to improve outcomes date. PARADIGM-2 is phase I dose escalation study evaluating olaparib plus radiotherapy ± temozolomide in newly diagnosed glioblastoma, using MGMT methylation status stratify patients inform treatment schedules.
Abstract Real-time genomic sequencing has played a major role in tracking the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contributing greatly to disease mitigation strategies. In August 2020, after having eliminated virus, New Zealand experienced second outbreak. During that outbreak, used primary role, leading elimination virus. We generated genomes from 78% laboratory-confirmed samples SARS-CoV-2 outbreak and compared them with available data. Genomic...
Purpose To evaluate glioblastoma (GBM) metabolism by using hyperpolarized carbon 13 (13C) MRI to monitor the exchange of 13C label between injected [1-13C]pyruvate and tumor lactate bicarbonate. Materials Methods In this prospective study, seven treatment-naive patients (age [mean ± SD], 60 years 11; five men) with GBM were imaged at 3 T a dual-tuned 13C–hydrogen 1 head coil. Hyperpolarized was injected, signal acquired dynamic spiral sequence. Metabolism assessed within tumor, in...